ARFRP1 recruits ARL1 to the TGN

Stable Identifier
R-HSA-6814086
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ARFRP1 regulates Golgi localization of ARL1, another ARF-like GTPase that itself recruits a number of Golgin-tethering factors to the TGN. Knockout strains of ARL3, the yeast homologue of ARFRP1, abrogates Golgi localization of both yeast Arl1p and the four yeast Golgin homologues, suggesting a cascade of ARL proteins is contributes to retrograde trafficking at the TGN (Setty et al, 2003; Setty et al, 2004; Behnia et al, 2004; Panic et al, 2003; reviewed in Munro, 2005; Bonafacino and Rojas, 2006). GEF and GAP proteins that regulate ARFRP1 and ARL1 activity have not yet been identified (reviewed in Munro, 2005).

Literature References
PubMed ID Title Journal Year
16936697 Retrograde transport from endosomes to the trans-Golgi network

Bonifacino, JS, Rojas, R

Nat. Rev. Mol. Cell Biol. 2006
12620188 Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3

Setty, SR, Shin, ME, Yoshino, A, Marks, MS, Burd, CG

Curr. Biol. 2003
15077114 Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p

Setty, SR, Strochlic, TI, Tong, AH, Boone, C, Burd, CG

Nat. Cell Biol. 2004
15077113 Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p

Behnia, R, Panic, B, Whyte, JR, Munro, S

Nat. Cell Biol. 2004
16042553 The Arf-like GTPase Arl1 and its role in membrane traffic

Munro, S

Biochem. Soc. Trans. 2005
14580338 Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus

Panic, B, Perisic, O, Veprintsev, DB, Williams, RL, Munro, S

Mol. Cell 2003
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