SYS1 binds AcM-ARFRP1

Stable Identifier
R-HSA-6814088
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Acetylation of the N-terminal methionine of ARFRP1 contributes to its interaction with the Golgi-localized membrane protein SYS1. ARFRP1 is part of an ARF cascade at the late or trans-Golgi, where it plays a role in retrograde traffic by recruiting ARL1, which in turn interacts with a number of Golgin tethering factors required for vesicle docking at the TGN (Behnia et al, 2004; Setty et al, 2004; Shin et al, 2005; reviewed in Bonifacino and Rojas, 2006; Munro, 2011).

Literature References
PubMed ID Title Journal Year
15077114 Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p

Setty, SR, Strochlic, TI, Tong, AH, Boone, C, Burd, CG

Nat. Cell Biol. 2004
16936697 Retrograde transport from endosomes to the trans-Golgi network

Bonifacino, JS, Rojas, R

Nat. Rev. Mol. Cell Biol. 2006
15077113 Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p

Behnia, R, Panic, B, Whyte, JR, Munro, S

Nat. Cell Biol. 2004
16129887 Roles of ARFRP1 (ADP-ribosylation factor-related protein 1) in post-Golgi membrane trafficking

Shin, HW, Kobayashi, H, Kitamura, M, Waguri, S, Suganuma, T, Uchiyama, Y, Nakayama, K

J. Cell. Sci. 2005
21436057 The golgin coiled-coil proteins of the Golgi apparatus

Munro, S

Cold Spring Harb Perspect Biol 2011
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