Reactome: A Curated Pathway Database

NatC acetylates ARFFRP1

Stable Identifier
R-HSA-6814090
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ARFRP1 is an ARF family member GTPase that recruits ARL1 to the trans-Golgi network to play roles in retrograde trafficking of proteins from the endolysosomal system. ARFRP1 is an atypical ARF family member in that it is not myristolated, but is instead acetylated at the amino-terminal methionine by the NatC complex. Acetylation is required for the interaction of ARFRP1 with SYS1, which contributes to its targeting to its TGN (Behnia et al, 2004; Setty et al, 2004).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
peptide alpha-N-acetyltransferase activity of NAA30:NAA35:NAA38 [cytosol] NAA30:NAA35:NAA38 [cytosol] peptide alpha-N-acetyltransferase activity (0004596)
Inferred From