ARL1:GTP binds ARFIP2

Stable Identifier
R-HSA-6814094
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Two hybrid screening with human ARL1 as bait identified ARFIP2 as a novel ARL1:GTP-interacting partner (Van Valkenburgh et al, 2001). Interaction between ARFIP2 and ARL1 increases the amount of ARL1:GTP four-fold , although the significance of this is not clear (Van Vlakenburgh et al, 2001). ARFIP2 is also known to interact with RAC1 and to influence membrane ruffling (van Aelst et al, 1996; Tarricone et al, 2001)

Literature References
PubMed ID Title Journal Year
8670882 Identification of a novel Rac1-interacting protein involved in membrane ruffling

Van Aelst, L, Joneson, T, Bar-Sagi, D

EMBO J. 1996
11346801 The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways

Tarricone, C, Xiao, B, Justin, N, Walker, PA, Rittinger, K, Gamblin, SJ, Smerdon, SJ

Nature 2001
11303027 ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins

Van Valkenburgh, H, Shern, JF, Sharer, JD, Zhu, X, Kahn, RA

J. Biol. Chem. 2001
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