ARL1:GTP binds SCOC

Stable Identifier
R-HSA-6814096
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Two hybrid screening with human ARL1 as bait identified SCOC as a novel ARL1:GTP-interacting partner (Van Valkenburgh et al, 2001). SCOC (short coiled coil) shares 26% identity and 51% homology with GOLGA2, binds ARL1:GTPagamma S as assessed by affinity chromatography and shows extensive colocalization wtih beta-COP and ARL1 at the Golgi, however the role of this complex is not known (Van Valkenbrugh et al, 2001). SCOC is also known to play roles in autophagy, as part of a complex with FEZ1 (McKnight et al, 2012; reviewed in Joachim et al, 2012).

Literature References
PubMed ID Title Journal Year
11303027 ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins

Van Valkenburgh, H, Shern, JF, Sharer, JD, Zhu, X, Kahn, RA

J. Biol. Chem. 2001
22354037 Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC

McKnight, NC, Jefferies, HB, Alemu, EA, Saunders, RE, Howell, M, Johansen, T, Tooze, SA

EMBO J. 2012
22717455 Coiling up with SCOC and WAC: two new regulators of starvation-induced autophagy

Joachim, J, Wirth, M, McKnight, NC, Tooze, SA

Autophagy 2012
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