GDPD5 hydrolyzes GPCho

Stable Identifier
R-HSA-6814132
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GDPD5 (Glycerophosphodiester phosphodiesterase domain-containing protein 5; GDE2) catalyzes the hydrolysis of GPCho (glycero-3-phosphocholine) to G3P (glycerol-3-phosphate) and Cho (choline). The localization and activity of human GDPD5 are inferred from those of its better-characterized mouse homolog (Gallazzini et al. 2008).

Literature References
PubMed ID Title Journal Year
18667693 GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC

Gallazzini, M, Ferraris, JD, Burg, MB

Proc. Natl. Acad. Sci. U.S.A. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycerophosphocholine phosphodiesterase activity of GDPD5 [endoplasmic reticulum membrane]
Physical Entity
Activity
Inferred From
Cross References
Rhea
Authored
Reviewed
Created