PXLP-K333-GADL1 decarboxylates CSA to HTAU

Stable Identifier
R-HSA-6814165
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Acidic amino acid decarboxylase GADL1 (GADL1) can decarboxylate acidic amino acids such as cysteine sulfinic acid (CSA) to form hypotaurine (HTAU) (Liu et al. 2012, 2013). The dimeric structure of the enzyme is inferred from studies of its mouse homolog (Raasakka et al. 2018).

Literature References
PubMed ID Title Journal Year
22718265 Mechanism of cysteine-dependent inactivation of aspartate/glutamate/cysteine sulfinic acid α-decarboxylases

Liu, P, Torrens-Spence, MP, Ding, H, Christensen, BM, Li, J

Amino Acids 2013
23038267 Role of glutamate decarboxylase-like protein 1 (GADL1) in taurine biosynthesis

Liu, P, Ge, X, Ding, H, Jiang, H, Christensen, BM, Li, J

J. Biol. Chem. 2012
29372909 Structure of the mouse acidic amino acid decarboxylase GADL1

Raasakka, A, Mahootchi, E, Winge, I, Luan, W, Kursula, P, Haavik, J

Acta Crystallogr F Struct Biol Commun 2018
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
carboxy-lyase activity of PXLP-K333-GADL1 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created