Reactome | RPTN [cytosol]

RPTN [cytosol]

Stable Identifier

R-HSA-6814185

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Repetin, RPTN_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of the cornified envelope (Homo sapiens)
    - CASP14 cleaves filaggrin (Homo sapiens)
      - Late cornified envelope [plasma membrane] (Homo sapiens)
        
        Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        Minor CE proteins [cytosol] (Homo sapiens)
        
        RPTN [cytosol] (Homo sapiens)
      - Mature cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
        
        Minor CE proteins [cytosol] (Homo sapiens)
        
        RPTN [cytosol] (Homo sapiens)
    - CDSN binds the cornified envelope (Homo sapiens)
      - Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        Minor CE proteins [cytosol] (Homo sapiens)
        
        RPTN [cytosol] (Homo sapiens)
      - Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        Minor CE proteins [cytosol] (Homo sapiens)
        
        RPTN [cytosol] (Homo sapiens)
    - Lamellar bodies bind the early cornified envelope (Homo sapiens)
      - Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        Minor CE proteins [cytosol] (Homo sapiens)
        
        RPTN [cytosol] (Homo sapiens)
      - Early cornified envelope [plasma membrane] (Homo sapiens)
        
        Minor CE proteins [cytosol] (Homo sapiens)
        
        RPTN [cytosol] (Homo sapiens)
    - Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
      - Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        Minor CE proteins [cytosol] (Homo sapiens)
        
        RPTN [cytosol] (Homo sapiens)
      - Late cornified envelope [plasma membrane] (Homo sapiens)
        
        Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        Minor CE proteins [cytosol] (Homo sapiens)
        
        RPTN [cytosol] (Homo sapiens)
    - Plasma membrane resorption (Homo sapiens)
      - Mature cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
        
        Minor CE proteins [cytosol] (Homo sapiens)
        
        RPTN [cytosol] (Homo sapiens)
    - Reinforcement of the Cornified Envelope (Homo sapiens)
      - Early cornified envelope [plasma membrane] (Homo sapiens)
        
        Minor CE proteins [cytosol] (Homo sapiens)
        
        RPTN [cytosol] (Homo sapiens)
      - Minor CE proteins [cytosol] (Homo sapiens)
        
        RPTN [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6XPR3 RPTN

Gene Names

RPTN

Chain

chain:1-784

Reference Genes

BioGPS Gene:126638 RPTN

COSMIC (genes):RPTN RPTN

CTD Gene:126638 RPTN

dbSNP Gene:126638 RPTN

ENSEMBL:ENSG00000215853 RPTN

ENSEMBL_homo_sapiens_GENE:ENSG00000215853.3 RPTN

HGNC:26809 RPTN

KEGG Gene (Homo sapiens):126638 RPTN

Monarch:126638 RPTN

NCBI Gene:126638 RPTN

OMIM:613259 RPTN

UCSC:Q6XPR3 RPTN

Reference Transcript

RefSeq:NM_001122965.1 RPTN

Other Identifiers

11737529_a_at

126638

1553454_PM_at

1553454_at

16693295

2435468

2435469

2435470

2435471

2435472

2435473

2435474

2435475

2435476

2435477

2435478

2435493

7920146

A_23_P303286

GE560902

GO:0001533

GO:0005509

GO:0005576

GO:0005829

GO:0005886

GO:0046872

GO:0046914

HMNXSV003042572

Hs2.376144.1.S1_3p_at

ILMN_1753439

PH_hs_0018289

TC01003243.hg

Participates

as a member of

Minor CE proteins [cytosol] (Homo sapiens)

Other forms of this molecule

RPTN [cornified envelope]

Inferred To

RPTN [cytosol] (Bos taurus)

RPTN [cytosol] (Canis familiaris)

RPTN [cytosol] (Mus musculus)

RPTN [cytosol] (Sus scrofa)

Rptn [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001116437.1

OpenTargets

ENSG00000215853

HPA

ENSG00000215853-RPTN

GeneCards

Q6XPR3

Ensembl

ENST00000316073, ENSP00000317895, ENSG00000215853

PRO

Q6XPR3

Pharos - Targets

Q6XPR3

HMDB Protein

HMDBP07973