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DSC3 [plasma membrane]
Stable Identifier
R-HSA-6814396
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Desmocollin 3
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
CASP14 cleaves filaggrin (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
CDSN binds the cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Fillagrin and keratin intermediate filaments polymerize forming a network (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Lamellar bodies bind the early cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
PERP binds desmosomes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Desmosome:PERP [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Plasma membrane resorption (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Reinforcement of the Cornified Envelope (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14574 DSC3
Gene Names
DSC3, CDHF3, DSC4
Chain
signal peptide:1-27, propeptide:28-135, chain:136-896
Reference Genes
BioGPS Gene:1825 DSC3
COSMIC (genes):DSC3 DSC3
CTD Gene:1825 DSC3
dbSNP Gene:1825 DSC3
ENSEMBL:ENSG00000134762 DSC3
ENSEMBL_homo_sapiens_GENE:ENSG00000134762.17 DSC3
HGNC:3037 DSC3
KEGG Gene (Homo sapiens):1825 DSC3
Monarch:1825 DSC3
NCBI Gene:1825 DSC3
OMIM:600271 DSC3
UCSC:Q14574 DSC3
Reference Transcript
RefSeq:NM_024423.3 DSC3
RefSeq:NM_001941.4 DSC3
Other Identifiers
11733915_a_at
11743835_a_at
11754838_a_at
16854466
1825
206032_PM_at
206032_at
206033_3p_s_at
206033_PM_s_at
206033_s_at
244107_PM_at
244107_at
32417_at
3802935
3802936
3802937
3802938
3802939
3802940
3802941
3802942
3802943
3802944
3802945
3802947
3802948
3802950
3802951
3802952
3802953
3802957
3802958
3802959
3802960
3802962
3802963
3802964
3802965
3802967
3802969
3802970
47119_at
79615_at
8022692
84869_at
A_23_P208029
A_33_P3266898
D17427_at
GE500216
GE55693
GO:0001533
GO:0001701
GO:0005509
GO:0005576
GO:0005737
GO:0005886
GO:0005911
GO:0007155
GO:0007156
GO:0016020
GO:0030054
GO:0030057
GO:0045295
GO:0046872
GO:0048856
GO:0050821
GO:0070161
GO:0098609
HMNXSV003037781
Hs.166597.0.A1_3p_at
Hs.41690.0.A2_3p_at
ILMN_2359159
PH_hs_0003080
TC18000435.hg
X83929_s_at
g13435367_3p_a_at
Participates
as a member of
Desmocolins [plasma membrane] (Homo sapiens)
Other forms of this molecule
DSC3 [cornified envelope]
Inferred To
dsc2l [plasma membrane]
(Danio rerio)
Dsc3 [plasma membrane]
(Mus musculus)
Dsc3 [plasma membrane]
(Rattus norvegicus)
cdh-4 [plasma membrane]
(Caenorhabditis elegans)
DSC3 [plasma membrane]
(Bos taurus)
DSC3 [plasma membrane]
(Canis familiaris)
DSC3 [plasma membrane]
(Gallus gallus)
DSC3 [plasma membrane]
(Sus scrofa)
dsc3 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001932.2
,
NP_077741.2
OpenTargets
ENSG00000134762
GeneCards
Q14574
HPA
ENSG00000134762-DSC3
Ensembl
ENST00000434452
,
ENSG00000134762
,
ENST00000360428
,
ENSP00000353608
,
ENSP00000392068
PRO
Q14574
Pharos - Targets
Q14574
Orphanet
18928
HMDB Protein
HMDBP07657
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