PERP binds desmosomes

Stable Identifier
R-HSA-6814695
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PERP (p53 effector related to PMP-22) is a p53/p63 target gene involved in DNA damage-induced apoptosis (Flores et al. 2002). It is a tetraspan membrane protein,distantly related to members of the claudin/PMP-22/EMP family of four-pass membrane proteins (Attardi et al. 2000). It has an epithelial-specific expression pattern during embryogenesis and localizes to desmosomes. Perp -/- knockout mice exhibit numerous desmosomal structural defects, suggesting a role for Perp in promoting the stable assembly of desmosomal adhesive complexes (Ihrie et al. 2005).

Literature References
PubMed ID Title Journal Year
15797384 Perp is a p63-regulated gene essential for epithelial integrity

Ihrie, RA, Marques, MR, Nguyen, BT, Horner, JS, Papazoglu, C, Bronson, RT, Mills, AA, Attardi, LD

Cell 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created