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Plasma membrane resorption
Stable Identifier
R-HSA-6814764
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
,
cornified envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
Plasma membrane resorption (Homo sapiens)
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In differentiating keratinocytes, fusion of lamellar body (LB) membranes with the plasma membrane enriches the plasma membrane with lipids including omega-OH-ceramides. Their fatty acid chains are long enough to span the lipid bilayer, so that the omega-OH projects into the cell. In vitro data have shown that the membrane-anchored transglutaminase 1 enzyme can covalently esterify these ceramides onto glutamine residues of cornified envelope scaffold proteins (Nemes et al. 1999). Eventually, the ceramides replace the bilayer plasma membrane and are thought to serve to interdigitate with and organize the extracellular lipids into characteristic lamellae (Kalinin et al. 2001).
Literature References
PubMed ID
Title
Journal
Year
11590230
Assembly of the epidermal cornified cell envelope
Steinert, PM
,
Kalinin, A
,
Marekov, LN
J. Cell. Sci.
2001
10411887
A novel function for transglutaminase 1: attachment of long-chain omega-hydroxyceramides to involucrin by ester bond formation
Fésüs, L
,
Steinert, PM
,
Nemes, Z
,
Marekov, LN
Proc. Natl. Acad. Sci. U.S.A.
1999
Participants
Input
Mature cornified envelope [plasma membrane]
(Homo sapiens)
Output
Mature cornified envelope [cornified envelope]
(Homo sapiens)
Participates
as an event of
Formation of the cornified envelope (Homo sapiens)
Orthologous Events
Plasma membrane resorption (Bos taurus)
Plasma membrane resorption (Canis familiaris)
Plasma membrane resorption (Mus musculus)
Plasma membrane resorption (Rattus norvegicus)
Plasma membrane resorption (Sus scrofa)
Authored
Jupe, S (2016-03-10)
Reviewed
Blumenberg, M (2016-08-12)
Created
Jupe, S (2015-11-27)
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