Plasma membrane resorption

Stable Identifier
R-HSA-6814764
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In differentiating keratinocytes, fusion of lamellar body (LB) membranes with the plasma membrane enriches the plasma membrane with lipids including omega-OH-ceramides. Their fatty acid chains are long enough to span the lipid bilayer, so that the omega-OH projects into the cell. In vitro data have shown that the membrane-anchored transglutaminase 1 enzyme can covalently esterify these ceramides onto glutamine residues of cornified envelope scaffold proteins (Nemes et al. 1999). Eventually, the ceramides replace the bilayer plasma membrane and are thought to serve to interdigitate with and organize the extracellular lipids into characteristic lamellae (Kalinin et al. 2001).

Literature References
PubMed ID Title Journal Year
10411887 A novel function for transglutaminase 1: attachment of long-chain omega-hydroxyceramides to involucrin by ester bond formation

Nemes, Z, Marekov, LN, Fésüs, L, Steinert, PM

Proc. Natl. Acad. Sci. U.S.A. 1999
11590230 Assembly of the epidermal cornified cell envelope

Kalinin, A, Marekov, LN, Steinert, PM

J. Cell. Sci. 2001
Participants
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Orthologous Events
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