Glycerophospholipid catabolism

Stable Identifier
R-HSA-6814848
Type
Pathway
Species
Homo sapiens
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Reactions grouped in this pathway because of their shared chemistry - the hydrolysis of various phosphatidyl inositols and related phospholipids. They differ, however, in the tissues in which they occur and in their likely physiological roles. The activities of PNPLA6 and GDPD5 annotated here, for example, are especially prominent in kidney cells where the choline they generate plays a role in protecting cells from osmotic stress (Burg et al. 2007). Expression of others may be correlated with specific developmental events (Corda et al. 2013).

Literature References
PubMed ID Title Journal Year
24373430 The emerging physiological roles of the glycerophosphodiesterase family

Corda, D, Mosca, MG, Ohshima, N, Grauso, L, Yanaka, Noriyuki, Mariggi├▓, S

FEBS J. 2014
17928589 Cellular response to hyperosmotic stresses

Burg, MB, Ferraris, JD, Dmitrieva, NI

Physiol. Rev. 2007
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Orthologous Events
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