Reactome | RPRD1A [nucleoplasm]

RPRD1A [nucleoplasm]

Stable Identifier

R-HSA-6814899

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Regulation of nuclear pre-mRNA domain-containing protein 1A, RPR1A_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
      - RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
      - RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96P16 RPRD1A

Gene Names

RPRD1A, P15RS

Chain

initiator methionine:1, chain:2-312

Reference Genes

BioGPS Gene:55197 RPRD1A

COSMIC (genes):RPRD1A RPRD1A

CTD Gene:55197 RPRD1A

dbSNP Gene:55197 RPRD1A

ENSEMBL:ENSG00000141425 RPRD1A

HGNC:25560 RPRD1A

KEGG Gene (Homo sapiens):55197 RPRD1A

Monarch:55197 RPRD1A

NCBI Gene:55197 RPRD1A

OMIM:610347 RPRD1A

UCSC:Q96P16 RPRD1A

Reference Transcript

Other Identifiers

0002060647

11717351_s_at

11717352_a_at

11744617_a_at

11746776_a_at

1555202_a_at

16854713

218209_s_at

222558_at

222559_s_at

225953_at

2903169

3804146

3804147

3804148

3804149

3804150

3804151

3804152

3804153

3804172

3804173

3804176

3804177

3804178

3804180

3804188

3804189

3804190

49318_at

55197

57569_at

8022914

A_23_P55639

A_24_P382253

GE87293

GO:0000993

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006397

GO:0006464

GO:0008150

GO:0009058

GO:0016591

GO:0019899

GO:0031124

GO:0032991

GO:0034641

GO:0042795

GO:0043226

GO:0070940

Hs.300906.0.S2_3p_a_at

Hs2.300906.2.S1_3p_s_at

ILMN_1764207

ILMN_2209180

PH_hs_0015493

TC18000457.hg

g8922574_3p_a_at

Participant Of

hasMember

RPRD1A,B [nucleoplasm]

Inferred To

RTT103 [nucleoplasm] (Saccharomyces cerevisiae)

cids-1 [nucleoplasm] (Caenorhabditis elegans)

rprd1a [nucleoplasm] (Danio rerio)

rprd1a [nucleoplasm] (Xenopus tropicalis)

Homologues of RPRD1A [nucleoplasm] (Caenorhabditis elegans)

Rprd1a [nucleoplasm] (Mus musculus)

Rprd1a [nucleoplasm] (Rattus norvegicus)

Dmel\CG9018 [nucleoplasm] (Drosophila melanogaster)

RPRD1A [nucleoplasm] (Canis familiaris)

RPRD1A [nucleoplasm] (Gallus gallus)

RPRD1A [nucleoplasm] (Schizosaccharomyces pombe)

RPRD1A [nucleoplasm] (Sus scrofa)

nrd-1 [nucleoplasm] (Caenorhabditis elegans)

cids-2 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_060640.2, XP_011524351.1, NP_001290341.1, XP_011524350.1, XP_011524352.1, NP_001290342.1, NP_001290340.1

OpenTargets

ENSG00000141425

HPA

ENSG00000141425-RPRD1A

GeneCards

Q96P16

Ensembl

ENSP00000381984, ENSP00000465444, ENSP00000349955, ENST00000399022, ENST00000588737, ENSP00000467991, ENST00000357384, ENST00000590898, ENSG00000141425

PRO

Q96P16

PDB

4NAC, 4JXT

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.502	2

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