Reactome | NABP2 [nucleoplasm]

NABP2 [nucleoplasm]

Stable Identifier

R-HSA-6814916

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SOSS complex subunit B1, SOSB1_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP2 [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP2 [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP2 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP2 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BQ15 NABP2

Gene Names

NABP2, OBFC2B, SSB1, LP3587

Chain

chain:1-211

Reference Genes

BioGPS Gene:79035 NABP2

COSMIC (genes):NABP2 NABP2

CTD Gene:79035 NABP2

dbSNP Gene:79035 NABP2

ENSEMBL:ENSG00000139579 NABP2

HGNC:28412 NABP2

KEGG:hsa:79035 NABP2

Monarch:79035 NABP2

NCBI Gene:79035 NABP2

OMIM:612104 NABP2

UCSC:Q9BQ15 NABP2

Reference Transcript

Other Identifiers

11735707_x_at

11744625_x_at

16752586

218903_3p_s_at

218903_PM_s_at

218903_s_at

3417486

3417487

3417488

3417489

3417490

3417491

3417492

3417493

3417494

3417495

3417496

3417497

3417498

3417499

3417501

3417502

3417528

49370_at

79035

7956220

A_14_P136801

A_24_P283928

GE61987

GO:0000724

GO:0000781

GO:0003677

GO:0003697

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006281

GO:0006310

GO:0006974

GO:0010212

GO:0035861

GO:0043226

GO:0044818

GO:0070182

GO:0070200

GO:0070876

GO:0098505

GO:1904355

HMNXSV003006566

ILMN_1704672

PH_hs_0012923

TC12000507.hg

Participates

as a member of

NABP1,2 [nucleoplasm] (Homo sapiens)

Inferred To

NABP2 [nucleoplasm] (Bos taurus)

NABP2 [nucleoplasm] (Canis familiaris)

NABP2 [nucleoplasm] (Dictyostelium discoideum)

NABP2 [nucleoplasm] (Drosophila melanogaster)

NABP2 [nucleoplasm] (Gallus gallus)

NABP2 [nucleoplasm] (Sus scrofa)

nabp2 [nucleoplasm] (Xenopus tropicalis)

nabp-1 [nucleoplasm] (Caenorhabditis elegans)

Nabp2 [nucleoplasm] (Mus musculus)

Nabp2 [nucleoplasm] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000267023, ENSP00000368862, ENSP00000369545, ENST00000380198, ENST00000341463, ENSP00000267023

OpenTargets

ENSG00000139579

HPA

ENSG00000139579-NABP2

PRO

Q9BQ15

Pharos - Targets

Q9BQ15

GlyGen

Q9BQ15

PDB

4OWT, 5D8F, 5D8E, 4OWX, 8RBZ, 4OWW

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.619	7
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.602	4
UniProt:P54132 BLM	2	BLM [nucleoplasm] (R-HSA-174881) 4SUMO2,3-BLM [nucleoplasm] (R-HSA-4568883)	0.537	6
UniProt:Q06609 RAD51	2	RAD51 [nucleoplasm] (R-HSA-62637) p-T309-RAD51 [nucleoplasm] (R-HSA-5685231)	0.463	2