Reactome | CDK6 [cytosol]

CDK6 [cytosol]

Stable Identifier

R-HSA-68336

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cdk6, Cell division protein kinase 6 (EC 2.7.1.-)(Serine/threonine-protein kinase) (PLSTIRE)(CDK6), Cell division protein kinase 6 , Serine/threonine protein kinase PLSTIRE

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of cellular response to stress (Homo sapiens)
  - Diseases of Cellular Senescence (Homo sapiens)
    - Evasion of Oncogene Induced Senescence Due to p16INK4A Defects (Homo sapiens)
      - Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 (Homo sapiens)
        
        p16INK4A mutants do not bind CDK4,CDK6 (Homo sapiens)
        
        CDK4,CDK6 [cytosol] (Homo sapiens)
        
        CDK6 [cytosol] (Homo sapiens)
    - Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects (Homo sapiens)
      - Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 (Homo sapiens)
        
        p16INK4A mutants do not bind CDK4,CDK6 (Homo sapiens)
        
        CDK4,CDK6 [cytosol] (Homo sapiens)
        
        CDK6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q00534 CDK6

Gene Names

CDK6, CDKN6

Chain

chain:1-326

Reference Genes

BioGPS Gene:1021 CDK6

COSMIC (genes):CDK6 CDK6

CTD Gene:1021 CDK6

dbSNP Gene:1021 CDK6

ENSEMBL:ENSG00000105810 CDK6

HGNC:1777 CDK6

KEGG Gene (Homo sapiens):1021 CDK6

Monarch:1021 CDK6

NCBI Gene:1021 CDK6

OMIM:603368 CDK6

UCSC:Q00534 CDK6

Reference Transcript

Other Identifiers

0002510520

0103850332

1021

11723241_at

11723242_at

11723243_at

11723244_at

1207_at

17059756

207143_at

224847_at

224848_at

224851_at

231198_at

235287_at

243000_at

3061320

3061321

3061322

3061323

3061324

3061325

3061326

3061327

3061328

3061329

3061330

3061331

3061336

3061348

3061349

3061360

3061361

3061362

3061385

3061398

3061399

3061400

3061402

3061406

3061407

41545_at

57070_at

65733_at

69864_at

75209_r_at

75491_at

8140955

83673_at

89442_at

91819_at

A_23_P168651

A_24_P166663

GE80452

GE88785

GO:0000082

GO:0000122

GO:0000166

GO:0000278

GO:0000307

GO:0001726

GO:0001954

GO:0002244

GO:0002376

GO:0003323

GO:0003674

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006464

GO:0006468

GO:0006950

GO:0007049

GO:0007050

GO:0007155

GO:0007165

GO:0007219

GO:0007568

GO:0008150

GO:0008283

GO:0008285

GO:0008353

GO:0009058

GO:0009615

GO:0010468

GO:0010628

GO:0014002

GO:0016301

GO:0016310

GO:0016592

GO:0016740

GO:0021542

GO:0021670

GO:0030097

GO:0030154

GO:0030332

GO:0032991

GO:0033077

GO:0034641

GO:0040011

GO:0042063

GO:0042127

GO:0042592

GO:0042995

GO:0043167

GO:0043226

GO:0043697

GO:0045596

GO:0045638

GO:0045646

GO:0045656

GO:0045668

GO:0045786

GO:0048146

GO:0048699

GO:0048856

GO:0048870

GO:0050680

GO:0051301

GO:0051726

GO:0060218

GO:0097132

GO:0098770

GO:1902036

GO:2000134

GO:2000145

GO:2000773

Hs.143857.0.A1_3p_at

Hs.180059.0.S1_3p_at

Hs.180059.0.S2_3p_at

Hs.180059.0.S3_3p_at

Hs.209382.0.A1_3p_at

Hs.253015.0.A1_3p_at

ILMN_1802615

PH_hs_0002992

TC07001603.hg

TC07003061.hg

X66365_at

g4502740_3p_at

Participant Of

hasMember

CDK4,CDK6 [cytosol]

Other forms of this molecule

CDK6 [nucleoplasm]

p-T177-CDK6 [nucleoplasm]

Inferred To

Cdk6 [cytosol] (Mus musculus)

Cdk6 [cytosol] (Rattus norvegicus)

SSN3 [cytosol] (Saccharomyces cerevisiae)

cdk8 [cytosol] (Dictyostelium discoideum)

CDK6 [cytosol] (Bos taurus)

CDK6 [cytosol] (Canis familiaris)

CDK6 [cytosol] (Plasmodium falciparum)

CDK6 [cytosol] (Sus scrofa)

Pk34A [cytosol] (Drosophila melanogaster)

srb10 [cytosol] (Schizosaccharomyces pombe)

cdk-4 [cytosol] (Caenorhabditis elegans)

CAK1 [cytosol] (Saccharomyces cerevisiae)

YGK3 [cytosol] (Saccharomyces cerevisiae)

dyf-18 [cytosol] (Caenorhabditis elegans)

cdk6 [cytosol] (Danio rerio)

cdk6 [cytosol] (Gallus gallus)

cdk6 [cytosol] (Xenopus tropicalis)

Cdk4 [cytosol] (Drosophila melanogaster)

csk1 [cytosol] (Schizosaccharomyces pombe)

Homologues of CDK6 [cytosol] (Caenorhabditis elegans)

Homologues of CDK6 [cytosol] (Drosophila melanogaster)

Homologues of CDK6 [cytosol] (Saccharomyces cerevisiae)

Homologues of CDK6 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_006715898.1, NP_001138778.1, NP_001250.1

ZINC - World Drugs

CDK6_HUMAN

OpenTargets

ENSG00000105810

ZINC - FDA approved

CDK6_HUMAN

ZINC - Substances

CDK6_HUMAN

ZINC - Biogenic

CDK6_HUMAN

ZINC target

Q00534

PRO

Q00534

PDB

1G3N, 1BI8, 1BI7, 4TTH, 1JOW, 5L2I, 1BLX, 5L2S, 1XO2, 4AUA, 5L2T, 2EUF, 4EZ5, 3NUX, 3NUP, 2F2C

ZINC - Investigational

CDK6_HUMAN

ZINC - Metabolites

CDK6_HUMAN

HPA

ENSG00000105810-CDK6

GeneCards

Q00534

Ensembl

ENSP00000397087, ENST00000265734, ENST00000424848, ENSP00000265734, ENSG00000105810

ZINC - Predictions - Purchasable

CDK6_HUMAN

Orphanet

22579

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42773 CDKN2C	1	CDKN2C [cytosol] (R-HSA-182572)	0.967	25
UniProt:P30281 CCND3	2	CCND3 [cytosol] (R-HSA-68333) CCND3 [nucleoplasm] (R-HSA-113835)	0.967	26
UniProt:P55273 CDKN2D	1	CDKN2D [cytosol] (R-HSA-182580)	0.954	22
UniProt:P42771 CDKN2A	80	p16INK4A E88* [cytosol] (R-HSA-9632588) p16INK4A D84G [cytosol] (R-HSA-9632461) p16INK4A R87P [cytosol] (R-HSA-9632335) p16INK4A V126D [cytosol] (R-HSA-9631055) p16INK4A W110* [cytosol] (R-HSA-9632585) p16INK4A D84H [cytosol] (R-HSA-9632489) p16INK4A R80* [cytosol] (R-HSA-9632586) p16INK4A P114L [cytosol] (R-HSA-9630916) p16INK4A R58* [cytosol] (R-HSA-9632582) p16INK4A D84N [cytosol] (R-HSA-9632483) p16INK4A M53I [cytosol] (R-HSA-9630911) p16INK4A D84Y [cytosol] (R-HSA-9632478) p16INK4A G101W [cytosol] (R-HSA-9631257) p16INK4A P81L [cytosol] (R-HSA-9632280) p16INK4A A20P [cytosol] (R-HSA-9630805) p16INK4A D84V [cytosol] (R-HSA-9632465) p16INK4A P81T [cytosol] (R-HSA-9632275) p16INK4A P81H [cytosol] (R-HSA-9632293) p16INK4A D84A [cytosol] (R-HSA-9632486) p16INK4A P81R [cytosol] (R-HSA-9632294) p16INK4A E10* [cytosol] (R-HSA-9648382) p16INK4A S12* [cytosol] (R-HSA-9648383) p16INK4A P114T [cytosol] (R-HSA-9631034) p16INK4A P114S [cytosol] (R-HSA-9631027) p16INK4A G23fs3 [cytosol] (R-HSA-9648652) p16INK4A E61 [cytosol] (R-HSA-9648396) p16INK4A A20T [cytosol] (R-HSA-9630861) p16INK4A A36fs17 [cytosol] (R-HSA-9648653) p16INK4A E69 [cytosol] (R-HSA-9648397) p16INK4A W15fs1 [cytosol] (R-HSA-9648654) p16INK4A Y44 [cytosol] (R-HSA-9648398) p16INK4A T18fs15 [cytosol] (R-HSA-9648655) p16INK4A E26 [cytosol] (R-HSA-9648392) p16INK4A E33* [cytosol] (R-HSA-9648393) p16INK4A Q50* [cytosol] (R-HSA-9648394) p16INK4A E120* [cytosol] (R-HSA-9632587) p16INK4A S7fs8 [cytosol] (R-HSA-9648651) p16INK4A W15 [cytosol] (R-HSA-9648395) p16INK4A P75* [cytosol] (R-HSA-9648388) p16INK4A C72* [cytosol] (R-HSA-9648389) p16INK4A E119* [cytosol] (R-HSA-9648390) p16INK4A A20E [cytosol] (R-HSA-9630855) p16INK4A N39fs14 [cytosol] (R-HSA-9648647) p16INK4A P114R [cytosol] (R-HSA-9631046) p16INK4A P114H [cytosol] (R-HSA-9631043) p16INK4A E27 [cytosol] (R-HSA-9648387) p16INK4A P81S [cytosol] (R-HSA-9632287) p16INK4A G101V [cytosol] (R-HSA-9631263) p16INK4A Y44fs1 [cytosol] (R-HSA-9648664) p16INK4A V126I [cytosol] (R-HSA-9631130) p16INK4A L16fs9 [cytosol] (R-HSA-9648663) p16INK4A V126A [cytosol] (R-HSA-9631126) p16INK4A T18fs8 [cytosol] (R-HSA-9648656) p16INK4A V126F [cytosol] (R-HSA-9631120) p16INK4A L37fs16 [cytosol] (R-HSA-9648659) p16INK4A G35V [cytosol] (R-HSA-9631308) p16INK4A G23D [cytosol] (R-HSA-9630892) p16INK4A R24P [cytosol] (R-HSA-9630828) p16INK4A R80P [cytosol] (R-HSA-9632270) p16INK4A G35A [cytosol] (R-HSA-9631306) p16INK4A E88K [cytosol] (R-HSA-9632548) p16INK4A T77P [cytosol] (R-HSA-9632257) p16INK4A L97R [cytosol] (R-HSA-9632512) p16INK4A T18_A19dup [cytosol] (R-HSA-9632192) p16INK4A G67_N71del [cytosol] (R-HSA-9632252) p16INK4A A60R [cytosol] (R-HSA-9632216) p16INK4A D74Y [cytosol] (R-HSA-9632088) p16INK4A A60V [cytosol] (R-HSA-9632212) p16INK4A R112_L113insR [cytosol] (R-HSA-9632566) p16INK4A R99P [cytosol] (R-HSA-9632531) p16INK4A A60S [cytosol] (R-HSA-9632206) p16INK4A L97P [cytosol] (R-HSA-9632523) p16INK4A G23S [cytosol] (R-HSA-9631163) p16INK4A A60E [cytosol] (R-HSA-9632202) p16INK4A G23V [cytosol] (R-HSA-9631157) p16INK4A G35R [cytosol] (R-HSA-9631316) p16INK4A T77S [cytosol] (R-HSA-9632256) p16INK4A [cytosol] (R-HSA-182578) p16INK4A G35E [cytosol] (R-HSA-9631314) p16INK4A G35W [cytosol] (R-HSA-9631328)	0.934	15
UniProt:P42772 CDKN2B	1	CDKN2B [cytosol] (R-HSA-182586)	0.853	15
UniProt:P24385 CCND1	4	CCND1 [cytosol] (R-HSA-68328) CCND1 [nucleoplasm] (R-HSA-113832) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.734	4
UniProt:Q01196 RUNX1	5	MeR206,MeR210-RUNX1 [nucleoplasm] (R-HSA-8934750) RUNX1 [plasma membrane] (R-HSA-5667138) p-7Y-RUNX1 [nucleoplasm] (R-HSA-8937712) RUNX1 [nucleoplasm] (R-HSA-8865295) p-S249,S273,T276-RUNX1 [nucleoplasm] (R-HSA-8878063)	0.656	5
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.646	3
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585)	0.59	2
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.564	2
UniProt:Q14094 CCNI			0.556	3
UniProt:P41238 APOBEC1	1	APOBEC1(1-236) [nucleoplasm] (R-HSA-49459)	0.556	3
UniProt:P51946 CCNH	1	CCNH [nucleoplasm] (R-HSA-69220)	0.556	5
UniProt:Q9C019 TRI15			0.556	3
UniProt:Q5XKR4 OTP			0.556	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.524	2

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