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CDK6 [cytosol]
Stable Identifier
R-HSA-68336
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cdk6, Cell division protein kinase 6 (EC 2.7.1.-)(Serine/threonine-protein kinase) (PLSTIRE)(CDK6), Cell division protein kinase 6 , Serine/threonine protein kinase PLSTIRE
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Association of INK4 family proteins with CDK4/6 (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
CDK4,CDK6:INK4 [cytosol] (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Homo sapiens)
CDK4,CDK6:CCND [cytosol] (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] (Homo sapiens)
CDK4,CDK6:CCND [cytosol] (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
Formation of CDK4/6:CCND complexes (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
CDK4,CDK6:CCND [cytosol] (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
CDK4,CDK6:INK4 [cytosol] (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Homo sapiens)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [cytosol] (Homo sapiens)
CDK4,CDK6:CCND [cytosol] (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] (Homo sapiens)
CDK4,CDK6:CCND [cytosol] (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
CDK4,CDK6:CCND:p-Y88-CDKN1B [cytosol] (Homo sapiens)
CDK4,CDK6:CCND [cytosol] (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Homo sapiens)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] (Homo sapiens)
CDK4,CDK6:CCND [cytosol] (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
CDK4/6:CCND:p-Y77-CDKN1A,p-Y88-CDKN1B,(p-Y91-CDKN1C) [cytosol] (Homo sapiens)
CDK4,CDK6:CCND [cytosol] (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oncogene Induced Senescence (Homo sapiens)
Association of INK4 family proteins with CDK4/6 (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
CDK4,CDK6:INK4 [cytosol] (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Association of INK4 family proteins with CDK4/6 (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
CDK4,CDK6:INK4 [cytosol] (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
Association of INK4 family proteins with CDK4/6 (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
CDK4,CDK6:INK4 [cytosol] (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of cellular response to stress (Homo sapiens)
Diseases of Cellular Senescence (Homo sapiens)
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects (Homo sapiens)
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 (Homo sapiens)
p16INK4A mutants do not bind CDK4,CDK6 (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects (Homo sapiens)
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 (Homo sapiens)
p16INK4A mutants do not bind CDK4,CDK6 (Homo sapiens)
CDK4,CDK6 [cytosol] (Homo sapiens)
CDK6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00534 CDK6
Gene Names
CDK6, CDKN6
Chain
chain:1-326
Reference Genes
BioGPS Gene:1021 CDK6
COSMIC (genes):CDK6 CDK6
CTD Gene:1021 CDK6
dbSNP Gene:1021 CDK6
ENSEMBL:ENSG00000105810 CDK6
HGNC:1777 CDK6
KEGG Gene (Homo sapiens):1021 CDK6
Monarch:1021 CDK6
NCBI Gene:1021 CDK6
OMIM:603368 CDK6
UCSC:Q00534 CDK6
Reference Transcript
RefSeq:XM_006715835.2 CDK6
RefSeq:NM_001259.6 CDK6
RefSeq:NM_001145306.1 CDK6
Other Identifiers
0002510520
0103850332
1021
11723241_at
11723242_at
11723243_at
11723244_at
1207_at
17059756
207143_at
224847_at
224848_at
224851_at
231198_at
235287_at
243000_at
3061320
3061321
3061322
3061323
3061324
3061325
3061326
3061327
3061328
3061329
3061330
3061331
3061336
3061348
3061349
3061360
3061361
3061362
3061385
3061398
3061399
3061400
3061402
3061406
3061407
41545_at
57070_at
65733_at
69864_at
75209_r_at
75491_at
8140955
83673_at
89442_at
91819_at
A_23_P168651
A_24_P166663
GE80452
GE88785
GO:0000082
GO:0000122
GO:0000166
GO:0000278
GO:0000307
GO:0001726
GO:0001954
GO:0002244
GO:0002376
GO:0003323
GO:0003674
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006464
GO:0006468
GO:0006950
GO:0007049
GO:0007050
GO:0007155
GO:0007165
GO:0007219
GO:0007568
GO:0008150
GO:0008283
GO:0008285
GO:0008353
GO:0009058
GO:0009615
GO:0010468
GO:0010628
GO:0014002
GO:0016301
GO:0016310
GO:0016592
GO:0016740
GO:0021542
GO:0021670
GO:0030097
GO:0030154
GO:0030332
GO:0032991
GO:0033077
GO:0034641
GO:0040011
GO:0042063
GO:0042127
GO:0042592
GO:0042995
GO:0043167
GO:0043226
GO:0043697
GO:0045596
GO:0045638
GO:0045646
GO:0045656
GO:0045668
GO:0045786
GO:0048146
GO:0048699
GO:0048856
GO:0048870
GO:0050680
GO:0051301
GO:0051726
GO:0060218
GO:0097132
GO:0098770
GO:1902036
GO:2000134
GO:2000145
GO:2000773
Hs.143857.0.A1_3p_at
Hs.180059.0.S1_3p_at
Hs.180059.0.S2_3p_at
Hs.180059.0.S3_3p_at
Hs.209382.0.A1_3p_at
Hs.253015.0.A1_3p_at
ILMN_1802615
PH_hs_0002992
TC07001603.hg
TC07003061.hg
X66365_at
g4502740_3p_at
Participant Of
hasMember
CDK4,CDK6 [cytosol]
Other forms of this molecule
CDK6 [nucleoplasm]
p-T177-CDK6 [nucleoplasm]
Inferred To
Cdk6 [cytosol] (Mus musculus)
Cdk6 [cytosol] (Rattus norvegicus)
SSN3 [cytosol] (Saccharomyces cerevisiae)
cdk8 [cytosol] (Dictyostelium discoideum)
CDK6 [cytosol] (Bos taurus)
CDK6 [cytosol] (Canis familiaris)
CDK6 [cytosol] (Plasmodium falciparum)
CDK6 [cytosol] (Sus scrofa)
Pk34A [cytosol] (Drosophila melanogaster)
srb10 [cytosol] (Schizosaccharomyces pombe)
cdk-4 [cytosol] (Caenorhabditis elegans)
CAK1 [cytosol] (Saccharomyces cerevisiae)
YGK3 [cytosol] (Saccharomyces cerevisiae)
dyf-18 [cytosol] (Caenorhabditis elegans)
cdk6 [cytosol] (Danio rerio)
cdk6 [cytosol] (Gallus gallus)
cdk6 [cytosol] (Xenopus tropicalis)
Cdk4 [cytosol] (Drosophila melanogaster)
csk1 [cytosol] (Schizosaccharomyces pombe)
Homologues of CDK6 [cytosol] (Caenorhabditis elegans)
Homologues of CDK6 [cytosol] (Drosophila melanogaster)
Homologues of CDK6 [cytosol] (Saccharomyces cerevisiae)
Homologues of CDK6 [cytosol] (Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001250.1
,
NP_001138778.1
,
XP_006715898.1
ZINC - World Drugs
CDK6_HUMAN
OpenTargets
ENSG00000105810
ZINC - FDA approved
CDK6_HUMAN
ZINC - Substances
CDK6_HUMAN
ZINC - Biogenic
CDK6_HUMAN
ZINC target
Q00534
PRO
Q00534
PDB
2F2C
,
5L2T
,
1XO2
,
2EUF
,
3NUP
,
1BI8
,
4TTH
,
5L2S
,
1BLX
,
1G3N
,
3NUX
,
4AUA
,
1JOW
,
1BI7
,
4EZ5
,
5L2I
ZINC - Investigational
CDK6_HUMAN
ZINC - Metabolites
CDK6_HUMAN
HPA
ENSG00000105810-CDK6
GeneCards
Q00534
Ensembl
ENSG00000105810
,
ENST00000424848
,
ENSP00000397087
,
ENST00000265734
,
ENSP00000265734
ZINC - Predictions - Purchasable
CDK6_HUMAN
Orphanet
22579
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30281 CCND3
2
CCND3 [cytosol]
(R-HSA-68333)
CCND3 [nucleoplasm]
(R-HSA-113835)
0.97
27
UniProt:P42773 CDKN2C
1
CDKN2C [cytosol]
(R-HSA-182572)
0.967
25
UniProt:P55273 CDKN2D
1
CDKN2D [cytosol]
(R-HSA-182580)
0.954
22
UniProt:P42771 CDKN2A
80
p16INK4A E88* [cytosol]
(R-HSA-9632588)
p16INK4A D84G [cytosol]
(R-HSA-9632461)
p16INK4A R87P [cytosol]
(R-HSA-9632335)
p16INK4A V126D [cytosol]
(R-HSA-9631055)
p16INK4A W110* [cytosol]
(R-HSA-9632585)
p16INK4A D84H [cytosol]
(R-HSA-9632489)
p16INK4A R80* [cytosol]
(R-HSA-9632586)
p16INK4A P114L [cytosol]
(R-HSA-9630916)
p16INK4A R58* [cytosol]
(R-HSA-9632582)
p16INK4A D84N [cytosol]
(R-HSA-9632483)
p16INK4A M53I [cytosol]
(R-HSA-9630911)
p16INK4A D84Y [cytosol]
(R-HSA-9632478)
p16INK4A G101W [cytosol]
(R-HSA-9631257)
p16INK4A P81L [cytosol]
(R-HSA-9632280)
p16INK4A A20P [cytosol]
(R-HSA-9630805)
p16INK4A D84V [cytosol]
(R-HSA-9632465)
p16INK4A P81T [cytosol]
(R-HSA-9632275)
p16INK4A P81H [cytosol]
(R-HSA-9632293)
p16INK4A D84A [cytosol]
(R-HSA-9632486)
p16INK4A P81R [cytosol]
(R-HSA-9632294)
p16INK4A E10* [cytosol]
(R-HSA-9648382)
p16INK4A S12* [cytosol]
(R-HSA-9648383)
p16INK4A P114T [cytosol]
(R-HSA-9631034)
p16INK4A P114S [cytosol]
(R-HSA-9631027)
p16INK4A G23fs*3 [cytosol]
(R-HSA-9648652)
p16INK4A E61* [cytosol]
(R-HSA-9648396)
p16INK4A A20T [cytosol]
(R-HSA-9630861)
p16INK4A A36fs*17 [cytosol]
(R-HSA-9648653)
p16INK4A E69* [cytosol]
(R-HSA-9648397)
p16INK4A W15fs*1 [cytosol]
(R-HSA-9648654)
p16INK4A Y44* [cytosol]
(R-HSA-9648398)
p16INK4A T18fs*15 [cytosol]
(R-HSA-9648655)
p16INK4A E26* [cytosol]
(R-HSA-9648392)
p16INK4A E33* [cytosol]
(R-HSA-9648393)
p16INK4A Q50* [cytosol]
(R-HSA-9648394)
p16INK4A E120* [cytosol]
(R-HSA-9632587)
p16INK4A S7fs*8 [cytosol]
(R-HSA-9648651)
p16INK4A W15* [cytosol]
(R-HSA-9648395)
p16INK4A P75* [cytosol]
(R-HSA-9648388)
p16INK4A C72* [cytosol]
(R-HSA-9648389)
p16INK4A E119* [cytosol]
(R-HSA-9648390)
p16INK4A A20E [cytosol]
(R-HSA-9630855)
p16INK4A N39fs*14 [cytosol]
(R-HSA-9648647)
p16INK4A P114R [cytosol]
(R-HSA-9631046)
p16INK4A P114H [cytosol]
(R-HSA-9631043)
p16INK4A E27* [cytosol]
(R-HSA-9648387)
p16INK4A P81S [cytosol]
(R-HSA-9632287)
p16INK4A G101V [cytosol]
(R-HSA-9631263)
p16INK4A Y44fs*1 [cytosol]
(R-HSA-9648664)
p16INK4A V126I [cytosol]
(R-HSA-9631130)
p16INK4A L16fs*9 [cytosol]
(R-HSA-9648663)
p16INK4A V126A [cytosol]
(R-HSA-9631126)
p16INK4A T18fs*8 [cytosol]
(R-HSA-9648656)
p16INK4A V126F [cytosol]
(R-HSA-9631120)
p16INK4A L37fs*16 [cytosol]
(R-HSA-9648659)
p16INK4A G35V [cytosol]
(R-HSA-9631308)
p16INK4A G23D [cytosol]
(R-HSA-9630892)
p16INK4A R24P [cytosol]
(R-HSA-9630828)
p16INK4A R80P [cytosol]
(R-HSA-9632270)
p16INK4A G35A [cytosol]
(R-HSA-9631306)
p16INK4A E88K [cytosol]
(R-HSA-9632548)
p16INK4A T77P [cytosol]
(R-HSA-9632257)
p16INK4A L97R [cytosol]
(R-HSA-9632512)
p16INK4A T18_A19dup [cytosol]
(R-HSA-9632192)
p16INK4A G67_N71del [cytosol]
(R-HSA-9632252)
p16INK4A A60R [cytosol]
(R-HSA-9632216)
p16INK4A D74Y [cytosol]
(R-HSA-9632088)
p16INK4A A60V [cytosol]
(R-HSA-9632212)
p16INK4A R112_L113insR [cytosol]
(R-HSA-9632566)
p16INK4A R99P [cytosol]
(R-HSA-9632531)
p16INK4A A60S [cytosol]
(R-HSA-9632206)
p16INK4A L97P [cytosol]
(R-HSA-9632523)
p16INK4A G23S [cytosol]
(R-HSA-9631163)
p16INK4A A60E [cytosol]
(R-HSA-9632202)
p16INK4A G23V [cytosol]
(R-HSA-9631157)
p16INK4A G35R [cytosol]
(R-HSA-9631316)
p16INK4A T77S [cytosol]
(R-HSA-9632256)
p16INK4A [cytosol]
(R-HSA-182578)
p16INK4A G35E [cytosol]
(R-HSA-9631314)
p16INK4A G35W [cytosol]
(R-HSA-9631328)
0.934
15
UniProt:P42772 CDKN2B
1
CDKN2B [cytosol]
(R-HSA-182586)
0.853
15
UniProt:P24385 CCND1
4
CCND1 [cytosol]
(R-HSA-68328)
CCND1 [nucleoplasm]
(R-HSA-113832)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
0.734
4
UniProt:Q01196 RUNX1
5
p-S249,S273,T276-RUNX1 [nucleoplasm]
(R-HSA-8878063)
RUNX1 [plasma membrane]
(R-HSA-5667138)
p-7Y-RUNX1 [nucleoplasm]
(R-HSA-8937712)
RUNX1 [nucleoplasm]
(R-HSA-8865295)
MeR206,MeR210-RUNX1 [nucleoplasm]
(R-HSA-8934750)
0.656
5
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.646
3
UniProt:P38936 CDKN1A
5
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
CDKN1A [cytosol]
(R-HSA-182512)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
CDKN1A [nucleoplasm]
(R-HSA-182585)
0.59
2
UniProt:P46527 CDKN1B
8
CDKN1B [nucleoplasm]
(R-HSA-182563)
CDKN1B [cytosol]
(R-HSA-198622)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.564
2
UniProt:Q14094 CCNI
0.556
3
UniProt:P41238 APOBEC1
1
APOBEC1(1-236) [nucleoplasm]
(R-HSA-49459)
0.556
3
UniProt:P51946 CCNH
1
CCNH [nucleoplasm]
(R-HSA-69220)
0.556
5
UniProt:Q9C019 TRI15
0.556
3
UniProt:Q5XKR4 OTP
0.556
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.524
2
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