Reactome: A Curated Pathway Database

CDK2

Stable Identifier
R-HSA-68365
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cdk2, Cell division protein kinase 2 (EC 2.7.1.-)(p33 protein kinase)(CDK2), Cell division protein kinase 2 , p33 protein kinase
Locations in the PathwayBrowser
External Reference Information
External Reference
UniProt:P24941 CDK2
Gene Names
CDK2, CDKN2
Chain
chain:1-298
Reference Genes
KEGG Gene (Homo sapiens):1017 CDK2, OMIM:116953 CDK2, COSMIC (genes):CDK2 CDK2, Monarch:1017 CDK2, BioGPS Gene:1017 CDK2, ENSEMBL:ENSG00000123374 CDK2, NCBI Gene:1017 CDK2, dbSNP Gene:1017 CDK2, HGNC:1771 CDK2, CTD Gene:1017 CDK2
Reference Transcript
Other Identifiers
 0002190091  0004590162  1017  11720781_a_at  11720782_a_at
 11741208_a_at  13115  16752305  1792_g_at  1833_at
 1AQ1  1B38  1B39  1BUH  1CKP
 1DI8  1DM2  1E1V  1E1X  1E9H
 1F5Q  1FIN  1FQ1  1FVT  1FVV
 1G5S  1GIH  1GII  1GIJ  1GY3
 1GZ8  1H00  1H01  1H07  1H08
 1H0V  1H0W  1H1P  1H1Q  1H1R
 1H1S  1H24  1H25  1H26  1H27
 1H28  1HCK  1HCL  1JST  1JSU
 1JSV  1JVP  1KE5  1KE6  1KE7
 1KE8  1KE9  1OGU  1OI9  1OIQ
 1OIR  1OIT  1OIU  1OIY  1OKV
 1OKW  1OL1  1OL2  1P2A  1P5E
 1PF8  1PKD  1PW2  1PXI  1PXJ
 1PXK  1PXL  1PXM  1PXN  1PXO
 1PXP  1PYE  1QMZ  1R78  1URC
 1URW  1V1K  1VYW  1VYZ  1W0X
 1W8C  1W98  1WCC  1Y8Y  1Y91
 1YKR  204252_at  211804_s_at  2A0C  2A4L
 2B52  2B53  2B54  2B55  2BHE
 2BHH  2BKZ  2BPM  2BTR  2BTS
 2C4G  2C5N  2C5O  2C5V  2C5X
 2C5Y  2C68  2C69  2C6I  2C6K
 2C6L  2C6M  2C6O  2C6T  2CCH
 2CCI  2CJM  2CLX  2DS1  2DUV
 2EXM  2FVD  2G9X  2HIC  2I40
 2IW6  2IW8  2IW9  2J9M  2JGZ
 2R3F  2R3G  2R3H  2R3I  2R3J
 2R3K  2R3L  2R3M  2R3N  2R3O
 2R3P  2R3Q  2R3R  2R64  2UUE
 2UZB  2UZD  2UZE  2UZL  2UZN
 2UZO  2V0D  2V22  2VTA  2VTH
 2VTI  2VTJ  2VTL  2VTM  2VTN
 2VTO  2VTP  2VTQ  2VTR  2VTS
 2VTT  2VU3  2VV9  2W05  2W06
 2W17  2W1H  2WEV  2WFY  2WHB
 2WIH  2WIP  2WMA  2WMB  2WPA
 2WXV  2X1N  2XMY  2XNB  3417147
 3417148  3417149  3417152  3417153  3417154
 3417155  3417157  3417158  3417159  3417160
 3BHT  3BHU  3BHV  3DDP  3DDQ
 3DOG  3EID  3EJ1  3EOC  3EZR
 3EZV  3F5X  3FZ1  3IG7  3IGG
 3LE6  3LFN  3LFQ  3LFS  3MY5
 3NS9  3PJ8  3PXF  3PXQ  3PXR
 3PXY  3PXZ  3PY0  3PY1  3QHR
 3QHW  3QL8  3QQF  3QQG  3QQH
 3QQJ  3QQK  3QQL  3QRT  3QRU
 3QTQ  3QTR  3QTS  3QTU  3QTW
 3QTX  3QTZ  3QU0  3QWJ  3QWK
 3QX2  3QX4  3QXO  3QXP  3QZF
 3QZG  3QZH  3QZI  3R1Q  3R1S
 3R1Y  3R28  3R6X  3R71  3R73
 3R7E  3R7I  3R7U  3R7V  3R7Y
 3R83  3R8L  3R8M  3R8P  3R8U
 3R8V  3R8Z  3R9D  3R9H  3R9N
 3R9O  3RAH  3RAI  3RAK  3RAL
 3RJC  3RK5  3RK7  3RK9  3RKB
 3RM6  3RM7  3RMF  3RNI  3ROY
 3RPO  3RPR  3RPV  3RPY  3RZB
 3S00  3S0O  3S1H  3S2P  3SQQ
 3SW4  3SW7  3TI1  3TIY  3TIZ
 3TNW  3ULI  3UNJ  3UNK  3WBL
 4ACM  4BCK  4BCM  4BCN  4BCO
 4BCP  4BCQ  4BGH  4BZD  4CFM
 4CFN  4CFU  4CFV  4CFW  4CFX
 4D1X  4D1Z  4EK3  4EK4  4EK5
 4EK6  4EK8  4EOI  4EOJ  4EOK
 4EOL  4EOM  4EON  4EOO  4EOP
 4EOQ  4EOR  4EOS  4ERW  4EZ3
 4EZ7  4FKG  4FKI  4FKJ  4FKL
 4FKO  4FKP  4FKQ  4FKR  4FKS
 4FKT  4FKU  4FKV  4FKW  4FX3
 4GCJ  4I3Z  4II5  4KD1  4LYN
 4NJ3  4RJ3  5A14  5AND  5ANE
 5ANG  5ANI  5ANJ  5ANK  5ANO
 5CYI  5D1J  5FP5  5FP6  5IEV
 5IEX  5IEY  5IF1  5JQ5  5JQ8
 5K4J  5L2W  5LMK  5LQE  5NEV
 66915  74635_at  7956076  A0A024RB10  A0A024RB77
 A_14_P122617  A_14_P129989  A_23_P98898  AAA35667  AAH03065
 AAM34794  AAP35467  AB012305  AC025162  AC034102
 AF512553  AK291941  BAA32794  BAF84630  BC003065
 BT006821  CAA43807  CAA43985  CAB013115  CCDS8898
 CCDS8899  CDK2  CDK2-201  CDK2-202  CH471054
 EAW96856  EAW96857  EAW96858  EAW96860  ENSG00000123374
 ENSP00000243067  ENSP00000266970  ENST00000266970  ENST00000354056  EntrezGene:1017
 g180177_3p_at  g3551190_3p_a_at  G3V5T9  GE81070  GO:0000003
 GO:0000082  GO:0000086  GO:0000122  GO:0000166  GO:0000278
 GO:0000307  GO:0000781  GO:0000793  GO:0000805  GO:0000806
 GO:0003674  GO:0004672  GO:0004674  GO:0004693  GO:0005515
 GO:0005524  GO:0005575  GO:0005622  GO:0005623  GO:0005634
 GO:0005654  GO:0005667  GO:0005694  GO:0005737  GO:0005768
 GO:0005813  GO:0005815  GO:0005829  GO:0005856  GO:0006259
 GO:0006260  GO:0006281  GO:0006464  GO:0006468  GO:0006810
 GO:0006813  GO:0006950  GO:0006974  GO:0006977  GO:0007010
 GO:0007049  GO:0007099  GO:0007165  GO:0007265  GO:0007275
 GO:0008150  GO:0008283  GO:0008284  GO:0009058  GO:0010033
 GO:0010389  GO:0015030  GO:0016301  GO:0016310  GO:0016572
 GO:0016740  GO:0018105  GO:0019904  GO:0022607  GO:0030332
 GO:0031410  GO:0031571  GO:0032298  GO:0034641  GO:0035173
 GO:0043167  GO:0043226  GO:0043234  GO:0045893  GO:0046872
 GO:0048856  GO:0051276  GO:0051298  GO:0051301  GO:0051321
 GO:0051436  GO:0051439  GO:0051726  GO:0060968  GO:0071732
 GO:0097123  GO:0097124  GO:0097134  GO:0097135  GO:0097472
 GO:1901796  HGNC:1771  HPA066915  Hs.19192  ILMN_1653443
 ILMN_1665559  IPR000719  IPR008271  IPR011009  IPR017441
 M68520  M68520_at  MIM:116953  NM_001798  NM_052827
 NP_001789  NP_439892  PF00069  PH_hs_0001687  SM00220
 TC12000496.hg  uc001sit.5  uc001siu.5  UPI00001105FA  UPI000013CB21
 X61622  X62071
Participant Of
input
hasComponent
Other forms of this molecule
p-Y15-CDK2 [nucleoplasm] CDK2 [cytosol] p-CDK2 [nucleoplasm] p-T160-CDK2 [nucleoplasm]
Inferred To
Cross References
RefSeq
NP_439892.2, NP_001277159.1, NP_001789.2
ZINC - World Drugs
CDK2_HUMAN
ZINC - FDA approved
CDK2_HUMAN
ZINC - Substances
CDK2_HUMAN
ZINC target
P24941
ZINC - Biogenic
CDK2_HUMAN
PRO
P24941
PDB
3RMF, 2R3Q, 2R3P, 2R3R, 3ROY, 3RPO, 3RNI, 3RK9, 2R3N, 3RK5, 2R3M, 3RK7, 3RM6, 3RM7, 3RKB, 2R3O, 3RAK, 2R3K, 2R3J, 3RAI, 2R3L, 3RAL, 3RJC, 3R9N, 2R3F, 3R9H, 2JGZ, 2R3H, 2R3I, 3RAH, 2R3G, 3R9O, 3TIZ, 3TNW, 2VTA, 3TIY, 2V0D, 1FVV, 2V22, 3ULI, 2VTI, 1G5S, 2VTH, 2UZE, 3SW4, 1F5Q, 2UZL, 1FIN, 1E1X, 1E9H, 3SQQ, 2UZO, 3SW7, 1FQ1, 3TI1, 1FVT, 2UZN, 1DI8, 1DM2, 1CKP, 3S00, 2UZD, 3S2P, 3S0O, 2UZB, 3S1H, 1E1V, 1AQ1, 3RPR, 2R64, 1B38, 3RZB, 2UUE, 3RPV, 1B39, 1BUH, 3RPY, 3R1S, 2C69, 3QZI, 2C68, 3R1Q, 3R28, 3R1Y, 2C6I, 2C5V, 3QZG, 5NEV, 3QXP, 5LMK, 3QZF, 2C5O, 3QZH, 2C5Y, 2C5X, 5JQ5, 2BTR, 5IF1, 2BKZ, 2BPM, 3QWJ, 3QWK, 3QX4, 5K4J, 3QXO, 2C4G, 2C5N, 5L2W, 3QX2, 2BTS, 5JQ8, 5IEV, 2BHE, 3QTX, 5FP6, 2B55, 5IEY, 3QU0, 5IEX, 3QTZ, 2BHH, 2I40, 2IW6, 3R8Z, 2HIC, 3R8V, 2J9M, 2IW8, 3R9D, 2IW9, 2DUV, 3R8M, 2EXM, 3R8L, 2DS1, 3R8U, 2G9X, 2FVD, 3R8P, 2CCI, 3R7V, 3R7I, 2CCH, 3R7U, 3R7Y, 2CLX, 3R83, 2CJM, 2C6L, 3R71, 2C6M, 2C6K, 3R6X, 2C6T, 3R73, 2C6O, 3R7E, 3PXQ, 1PXL, 4FKT, 1PXM, 4FKU, 1PXK, 4FKS, 3PXF, 1PXO, 4FKW, 3PXZ, 3PXR, 3PXY, 4FKV, 1PXN, 3LFS, 4FKO, 4FKP, 4FKL, 3LFQ, 1PKD, 4FKR, 3NS9, 3PJ8, 1PXJ, 1PW2, 1PXI, 3MY5, 4FKQ, 4FKG, 3IG7, 3IGG, 4EZ7, 3FZ1, 1OL2, 1P2A, 4FKJ, 3LE6, 1PF8, 3LFN, 1P5E, 4FKI, 4ERW, 3EOC, 1OKV, 3EID, 1OIY, 4EOS, 3EJ1, 1OL1, 3F5X, 1OKW, 3EZR, 4EZ3, 3EZV, 5ANO, 3QTR, 2A4L, 2B52, 5ANJ, 2A0C, 5ANK, 3QTQ, 3QTU, 2B53, 5FP5, 2B54, 3QTW, 5CYI, 5D1J, 3QTS, 3QQK, 1WCC, 5ANE, 1W98, 5AND, 3QRU, 1YKR, 1Y8Y, 3QQL, 5ANG, 1Y91, 5ANI, 3QRT, 1VYW, 3QQG, 1URW, 3QQF, 1V1K, 4LYN, 1W0X, 3QQJ, 5A14, 1W8C, 4NJ3, 3QQH, 1VYZ, 4RJ3, 4GCJ, 1PYE, 3PY1, 3QHR, 1QMZ, 3PY0, 1PXP, 4FX3, 3QL8, 1URC, 4II5, 4KD1, 4I3Z, 1R78, 3QHW, 1H25, 2W17, 4CFU, 2W1H, 1H24, 4CFW, 2WFY, 1H27, 1H26, 2WEV, 4CFV, 4BGH, 1H1P, 4BCQ, 2VTT, 2VU3, 1H0W, 1H1R, 4CFM, 2W06, 1H1S, 4CFN, 2VV9, 4BZD, 2W05, 1H1Q, 4BCN, 1H01, 2VTP, 2VTQ, 2VTO, 4BCM, 1H00, 2VTS, 1H08, 4BCP, 1H0V, 4BCO, 1H07, 2VTR, 2VTJ, 2VTL, 3UNK, 3UNJ, 1GIH, 1GII, 4ACM, 1GY3, 1GZ8, 2VTN, 4BCK, 3WBL, 1GIJ, 2VTM, 3BHV, 4EOO, 1OIR, 4EOP, 1OI9, 3BHU, 4EON, 1OIQ, 1OIU, 4EOQ, 3DOG, 4EOR, 3DDP, 3DDQ, 1OIT, 4EOK, 2XMY, 4EOL, 1KE9, 2X1N, 1KE8, 4EOM, 3BHT, 1OGU, 2XNB, 4EK6, 1JVP, 2WMB, 2WMA, 1JSV, 4EK5, 1KE6, 4EOI, 1KE7, 4EOJ, 2WXV, 4EK8, 1HCL, 2WIH, 4EK3, 4D1Z, 1JSU, 2WIP, 4EK4, 1JST, 1H28, 2WHB, 4D1X, 4CFX, 1HCK, 2WPA, 1KE5
UCSC human
P24941
GeneCards
P24941
DOCK Blaster
2CJM, 1B38, 3RK9, 3RK7, 3RK5, 3RKB, 2X1N, 5ANO, 3DOG, 5ANK, 5ANJ, 2WPA, 5ANI, 5AND, 2G9X, 5ANG, 5ANE, 1F5Q, 1AQ1, 1B39, 3RJC, 4FX3, 4KD1, 1QMZ, 2FVD, 2WMB, 2WMA, 3QZI, 3QZH, 3QZG, 3QZF, 5K4J, 3RAI, 3RAH, 3RAL, 3RAK, 2CCH, 2CCI, 3RPO, 5NEV, 1R78, 3ROY, 3TNW, 3S1H, 2V22, 1GZ8, 1FIN, 3S0O, 2A4L, 3S00, 3MY5, 2V0D, 4II5, 3RNI, 3TIZ, 1GY3, 3TIY, 2J9M, 5D1J, 2IW6, 2IW8, 2CLX, 2IW9, 2A0C, 3RMF, 4GCJ, 3RM7, 3RM6, 3TI1, 3EZV, 3EZR, 2C4G, 2C5X, 2C5Y, 4LYN, 3QRU, 2C5V, 2C69, 3QRT, 2C68, 1E9H, 3QTR, 3QTQ, 3QU0, 1W98, 3R28, 2R3F, 2R3N, 4BCP, 2R3P, 2R3O, 4BCO, 2R3R, 4BCN, 2R3Q, 4BCM, 3R1Y, 1VYW, 2R3L, 4I3Z, 2R3K, 1VYZ, 4BCQ, 2R3M, 4BCK, 1JVP, 4FKG, 3R1Q, 4FKP, 3QQL, 3QQK, 2VV9, 3QQG, 3QQF, 1W8C, 2R3H, 3R1S, 2R3G, 2R3I, 2R3J, 3QQJ, 3QQH, 4FKQ, 2EXM, 5A14, 4FKU, 2VU3, 4FKT, 2VTR, 2VTQ, 2VTP, 2BPM, 4FKS, 4FKR, 4FKO, 4FKL, 4FKJ, 4FKI, 4FKW, 4FKV, 2VTT, 2VTS, 1H1S, 3R7Y, 2WIH, 1H25, 3QXP, 1H1R, 3R9O, 3QXO, 3R9N, 1H24, 3R8Z, 3R9H, 3R9D, 3SW7, 2WHB, 3QX2, 3R8V, 3R8U, 1H1Q, 3SW4, 3QX4, 3QWK, 3QWJ, 1H28, 5JQ8, 1H1P, 5JQ5, 2WIP, 1H26, 3R8P, 3BHV, 1H27, 3R8M, 3BHU, 3R8L, 3BHT, 1PXK, 3QTZ, 1PXJ, 3QTX, 1PXL, 1PXN, 3QTW, 1PXM, 1PXO, 1H07, 3R7U, 2WEV, 2C6M, 1H01, 2C6O, 1PXI, 3R83, 2WFY, 3R7I, 3DDQ, 3DDP, 3R7V, 1PYE, 3R6X, 1H0W, 1H0V, 3R7E, 2BTR, 1WCC, 2BTS, 1PW2, 3QTU, 3QTS, 2C5N, 3SQQ, 2C5O, 2R64, 1KE8, 2C6L, 1KE7, 1KE9, 3R73, 3R71, 2C6T, 1PXP, 1H08, 1H00, 4BGH, 2C6K, 1KE6, 2C6I, 1KE5, 4D1X, 1YKR, 3EOC, 2W1H, 1DM2, 3PXF, 3RZB, 4D1Z, 2W06, 2W05, 1URW, 1BUH, 3PXZ, 3PXY, 1P5E, 3PXR, 3PXQ, 3PY1, 3PY0, 1DI8, 3WBL, 1HCL, 3EJ1, 1URC, 3EID, 1E1V, 1JST, 1JSU, 1GIH, 1JSV, 1GII, 3UNK, 3UNJ, 1W0X, 3QL8, 3QHR, 2BKZ, 1PKD, 3QHW, 2I40, 2VTN, 2VTM, 2VTL, 2VTJ, 2VTI, 2VTH, 1CKP, 1GIJ, 1E1X, 2VTA, 3F5X, 2VTO, 4EZ7, 4EZ3, 1PF8, 2BHE, 2BHH, 2W17, 3ULI, 1OGU, 1OI9, 1OIQ, 1FQ1, 1OIR, 1OIU, 3LFS, 3LFQ, 4BZD, 3LFN, 1OIY, 4EK8, 4EK6, 4EK5, 3RPY, 5IEV, 5IEX, 3RPR, 5IEY, 3LE6, 5CYI, 3RPV, 5L2W, 2JGZ, 3S2P, 2UUE, 2WXV, 3FZ1, 5IF1, 5FP5, 5FP6, 4EK4, 4EK3, 4RJ3, 3PJ8, 1P2A, 4CFX, 4CFW, 1G5S, 4ERW, 2XMY, 1V1K, 4NJ3, 1FVV, 1FVT, 2B55, 2B54, 4CFV, 4CFU, 2B53, 2B52, 2XNB, 4CFN, 4CFM, 1HCK, 3NS9, 4EOM, 2UZE, 4EOL, 2UZD, 4EOK, 4EOJ, 2UZB, 1Y8Y, 1Y91, 3IG7, 4EOS, 5LMK, 1OKW, 1OKV, 2UZL, 4EOI, 2UZN, 1OL2, 4EOP, 2UZO, 3IGG, 4EOQ, 1OL1, 4EOR, 2DS1, 4ACM, 4EON, 4EOO, 1OIT, 2DUV
ZINC - Predictions - Purchasable
CDK2_HUMAN
HMDB Protein
HMDBP01383
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.969 P20248 CCNA2_HUMAN 24
0.964 P38936 CDN1A_HUMAN 20
0.962 P46527 CDN1B_HUMAN 21
0.948 P24864 CCNE1_HUMAN 18
0.88 O96020 CCNE2_HUMAN 9
0.861 P61024 CKS1_HUMAN 7
0.844 Q16667 CDKN3_HUMAN 7
0.788 Q13309 SKP2_HUMAN 7
0.758 Q08999 RBL2_HUMAN 5
0.729 Q96PU4 UHRF2_HUMAN 5
0.725 P14635 CCNB1_HUMAN 6
0.693 P51946 CCNH_HUMAN 3
0.659 P24385 CCND1_HUMAN 3
0.643 P28749 RBL1_HUMAN 4
0.643 Q9H211 CDT1_HUMAN 3
0.643 P63208 SKP1_HUMAN 4
0.643 P33552 CKS2_HUMAN 3
0.641 Q09472 EP300_HUMAN 5
0.633 Q9Y6K9 NEMO_HUMAN 4
0.623 P06400 RB_HUMAN 3
0.623 Q8TD08 MK15_HUMAN 4
0.59 O95067 CCNB2_HUMAN 2
0.564 Q99523 SORT_HUMAN 2
0.564 P03129 VE7_HPV16 2
0.544 Q08619 IFI5B_MOUSE 2
0.527 Q08379 GOGA2_HUMAN 2
0.527 Q92793 CBP_HUMAN 2
0.527 P49918 CDN1C_HUMAN 2
0.527 Q14004 CDK13_HUMAN 2
0.488 Q8NA61-2 SPERT 2
0.488 Q8N448 LNX2_HUMAN 2
 
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