CDK2 [nucleoplasm]

Stable Identifier
R-HSA-68365
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cdk2, Cell division protein kinase 2 (EC 2.7.1.-)(p33 protein kinase)(CDK2), Cell division protein kinase 2 , p33 protein kinase
Icon
CDK2 [nucleoplasm] icon
CDK2 [nucleoplasm] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P24941 CDK2
Gene Names
CDK2, CDKN2
Chain
chain:1-298
Reference Genes
BioGPS Gene:1017 CDK2
COSMIC (genes):CDK2 CDK2
CTD Gene:1017 CDK2
dbSNP Gene:1017 CDK2
ENSEMBL:ENSG00000123374 CDK2
HGNC:1771 CDK2
KEGG Gene (Homo sapiens):1017 CDK2
Monarch:1017 CDK2
NCBI Gene:1017 CDK2
OMIM:116953 CDK2
UCSC:P24941 CDK2
Reference Transcript
Other Identifiers
0002190091
0004590162
1017
11720781_a_at
11720782_a_at
11741208_a_at
16752305
1792_g_at
1833_at
204252_at
211804_s_at
3417147
3417148
3417149
3417152
3417153
3417154
3417155
3417157
3417158
3417159
3417160
74635_at
7956076
A_14_P122617
A_14_P129989
A_23_P98898
GE724134
GE81070
GO:0000003
GO:0000082
GO:0000086
GO:0000166
GO:0000278
GO:0000307
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006259
GO:0006260
GO:0006270
GO:0006281
GO:0006464
GO:0006468
GO:0006950
GO:0006974
GO:0007004
GO:0007010
GO:0007049
GO:0007099
GO:0007165
GO:0007265
GO:0008150
GO:0008283
GO:0008284
GO:0009056
GO:0009058
GO:0010389
GO:0010468
GO:0015030
GO:0016301
GO:0016310
GO:0016572
GO:0016740
GO:0018105
GO:0019904
GO:0022607
GO:0030154
GO:0030332
GO:0030851
GO:0031145
GO:0031410
GO:0031571
GO:0032991
GO:0034641
GO:0035173
GO:0042592
GO:0043167
GO:0043226
GO:0046872
GO:0048856
GO:0051276
GO:0051298
GO:0051301
GO:0051321
GO:0060968
GO:0071732
GO:0097123
GO:0097124
GO:0097134
GO:0097135
GO:0097472
GO:0106310
GO:0106311
GO:1901796
HMNXSV003002576
ILMN_1653443
ILMN_1665559
ILMN_1908231
M68520_at
PH_hs_0001687
TC12000496.hg
g180177_3p_at
g3551190_3p_a_at
Participates
as a component of
as an input of
Other forms of this molecule
p-Y15-CDK2 [nucleoplasm]
p-CDK2 [nucleoplasm]
CDK2 [cytosol]
p-T160-CDK2 [nucleoplasm]
Inferred To
CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Canis familiaris)
CDK2 [nucleoplasm] (Gallus gallus)
CDK2 [nucleoplasm] (Plasmodium falciparum)
CDC28 [nucleoplasm] (Saccharomyces cerevisiae)
Ghost homologue of CDK2 [nucleoplasm] (Sus scrofa)
Ghost homologue of CDK2 [nucleoplasm] (Xenopus tropicalis)
cdk-2 [nucleoplasm] (Caenorhabditis elegans)
cdk2 [nucleoplasm] (Danio rerio)
Cdk2 [nucleoplasm] (Drosophila melanogaster)
Cdk2 [nucleoplasm] (Mus musculus)
Cdk2 [nucleoplasm] (Rattus norvegicus)
cdk1 [nucleoplasm] (Dictyostelium discoideum)
cdc2 [nucleoplasm] (Schizosaccharomyces pombe)
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
GlyGen
PDB
3R8Z, 1H27, 1OL1, 2R64, 2R3R, 2VTH, 3BHV, 3PJ8, 5UQ2, 3RJC, 6Q4G, 5UQ3, 2XMY, 2W05, 2C6L, 4EK3, 3SW7, 3QTS, 1H26, 2VTA, 2CCI, 4NJ3, 2R3Q, 3BHU, 1Y91, 5A14, 1P2A, 2V22, 2FVD, 5UQ1, 3S2P, 6SG4, 6Q4F, 3PY1, 5FP6, 2B55, 5LMK, 2C6K, 4FKW, 1P5E, 3QTR, 4ACM, 3R8V, 1OKW, 3SW4, 1OKV, 2CCH, 1H25, 2R3P, 3BHT, 6Q4D, 3S0O, 1Y8Y, 2C69, 5FP5, 6Q4E, 3PY0, 2B54, 2G9X, 2C6I, 2V0D, 4FKV, 1R78, 3S1H, 1GZ8, 3R8U, 3QTQ, 1OIY, 3QRU, 3UNK, 1OIU, 4KD1, 2R3O, 1H24, 4BZD, 3QQL, 4EOS, 2C68, 6Q4C, 1GY3, 2B53, 3PXZ, 4CFX, 3R8P, 4FKU, 2X1N, 3QRT, 3S00, 6INL, 6GUF, 6YL1, 4RJ3, 4BCO, 3QTZ, 3RKB, 4EOJ, 6P3W, 3RAL, 5MHQ, 1H00, 1DI8, 2VTM, 3R9O, 3R1Y, 3MY5, 6OQI, 4FKG, 2UUE, 1DM2, 1KE7, 5ANI, 6Q4K, 1PXK, 4LYN, 3R71, 2R3F, 3RM6, 1GIJ, 2UZD, 4EK8, 4BCN, 6GUE, 3QTX, 4EOI, 3RAK, 3R1S, 2VTL, 3R9N, 1E1X, 1E1V, 1KE6, 5ANG, 6Q4J, 1PXJ, 3R6X, 2UZB, 1GII, 3RK9, 3IGG, 4EK6, 2C6T, 3QTW, 4BCM, 6GUC, 3RAI, 3R1Q, 3EZV, 2VTJ, 3R9H, 2W17, 5ANE, 2W1H, 6JGM, 1PW2, 3IG7, 1KE5, 6Q4I, 1PXI, 4EK5, 3RK7, 2C6O, 1GIH, 1H28, 1OL2, 1CKP, 3EZR, 3R9D, 3RAH, 2VTI, 4I3Z, 3SQQ, 6Q4H, 5AND, 3DOG, 2JGZ, 1QMZ, 2XNB, 2W06, 4EK4, 2C6M, 1E9H, 3RK5, 6GUB, 4BCK, 3QTU, 2UZO, 3QQF, 2BHH, 2C5N, 5JQ5, 3R7U, 4EON, 4II5, 1FVV, 1FVT, 2VTR, 4CFM, 3LFN, 1PXO, 3NS9, 1H0V, 3LE6, 4FKP, 1PF8, 3RPR, 2WXV, 5IEV, 2R3J, 6Q3F, 3QXO, 1JVP, 5NEV, 2BHE, 2UZN, 1H08, 3R7I, 4EOM, 1JSV, 3QX2, 3RZB, 5OO3, 2VTP, 3ROY, 2VTQ, 3QX4, 4FKO, 2C4G, 1PXN, 2J9M, 1V1K, 5ANO, 3RPO, 2IW9, 3EJ1, 2R3I, 2BKZ, 6Q3C, 3R7E, 2UZL, 3RMF, 2BPM, 1PKD, 1H07, 4EOL, 6GUK, 4BCQ, 2BTS, 3WBL, 1VYZ, 5OO1, 3F5X, 3DDQ, 1WCC, 4FKJ, 3QWK, 2VTO, 1JSU, 1JST, 1YKR, 1KE9, 6GVA, 4FKL, 1PXM, 3EID, 3RNI, 6Q3B, 4GCJ, 2IW8, 5ANK, 5OSM, 2R3H, 5CYI, 4EOK, 6YL6, 4BCP, 2BTR, 1VYW, 6GUH, 1H01, 3R28, 5OO0, 3QWJ, 3DDP, 4FKI, 2VTN, 1URC, 3EOC, 1F5Q, 6YLK, 1KE8, 3FZ1, 5OSJ, 1PXL, 5ANJ, 2I40, 2IW6, 1URW, 3R73, 2R3G, 4BGH, 3RM7, 3QU0, 2UZE, 2R3N, 1OIT, 3UNJ, 3ULI, 1H1S, 2VV9, 2WMB, 3QQK, 2A0C, 2C5Y, 2WIP, 1W0X, 6Q4B, 2EXM, 4EOR, 2B52, 2CJM, 3PXY, 2CLX, 4CFW, 3R8M, 4FKT, 3QZI, 1FIN, 4ERW, 6RIJ, 2R3M, 2WMA, 1OIR, 2DUV, 1H1R, 3QQJ, 2WIH, 3R83, 2C5X, 6ATH, 2A4L, 4EOQ, 4EZ7, 6Q4A, 2DS1, 2VU3, 2WPA, 3PXR, 5IF1, 4FKS, 3R8L, 5L2W, 4CFV, 3QZH, 3QHW, 2WFY, 1B39, 1OIQ, 1H1Q, 3QQH, 4EZ3, 4EOP, 3PXF, 1W98, 2C5V, 6Q49, 1BUH, 3R7Y, 1HCL, 1G5S, 3QL8, 2WEV, 3PXQ, 1OI9, 4FX3, 2VTT, 4FKR, 2WHB, 7B5R, 3LFS, 3TIZ, 5IEY, 3QZG, 4CFU, 4D1Z, 5D1J, 3RPY, 2R3L, 1W8C, 3QXP, 1OGU, 1B38, 5JQ8, 3QQG, 2HIC, 6Q48, 3TNW, 3TI1, 2C5O, 1PYE, 1H1P, 4EOO, 3R7V, 5K4J, 1HCK, 1FQ1, 1PXP, 7B5L, 2VTS, 1H0W, 3LFQ, 4D1X, 4CFN, 4FKQ, 5IEX, 1AQ1, 3QZF, 3TIY, 3QHR, 3RPV, 2R3K
ZINC - Investigational
ZINC - Metabolites
GeneCards
HPA
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (50)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P38936 CDKN1A  5 0.975 29
 UniProt:P20248 CCNA2  3 0.975 28
 UniProt:P46527 CDKN1B  8 0.97 25
 UniProt:P24864 CCNE1  3 0.962 22
 UniProt:P61024 CKS1B  1 0.941 21
 UniProt:O96020 CCNE2  3 0.924 11
 UniProt:Q16667 CDKN3      0.889 8
 UniProt:Q13309 SKP2  3 0.837 8
 UniProt:Q08999 RBL2  2 0.812 6
 UniProt:P14635 CCNB1  4 0.788 7
 UniProt:O95067 CCNB2  1 0.77 4
 UniProt:P51946 CCNH  1 0.764 4
 UniProt:P24385 CCND1  4 0.738 4
 UniProt:Q96PU4 UHRF2  1 0.729 5
 UniProt:P33552 CKS2      0.725 4
 UniProt:P28749 RBL1  2 0.725 5
 UniProt:Q09472 EP300  5 0.723 6
 UniProt:P50613 CDK7  1 0.713 3
 UniProt:Q9H211 CDT1  2 0.643 3
 UniProt:Q92793 CREBBP  3 0.643 3
 UniProt:P63208 SKP1  2 0.643 4
 UniProt:Q9Y6K9 IKBKG  12 0.633 4
 UniProt:Q8TD08 MK15      0.623 4
 UniProt:P06400 RB1  20 0.623 3
 UniProt:Q9UQR0-1 SCML2      0.612 7
 UniProt:O95835 LATS1  2 0.576 4
 UniProt:P03129 VE7      0.564 2
 UniProt:Q99523 SORT1  2 0.564 2
 UniProt:P51943 Ccna2  4 0.558 2
 UniProt:P22607 FGFR3  20 0.556 3
 UniProt:P01112 HRAS  20 0.556 3
 UniProt:P06396 GSN  7 0.556 3
 UniProt:Q14957 GRIN2C  3 0.556 3
 UniProt:P30279 CCND2  2 0.547 2
 UniProt:P30274 CCNA2      0.544 2
 UniProt:Q08619 IFI5B      0.544 2
 UniProt:P49918-2 CDKN1C      0.527 2
 UniProt:P30281 CCND3  2 0.527 3
 UniProt:Q00526 CDK3      0.527 2
 UniProt:Q12834 CDC20  3 0.527 2
 UniProt:P49918 CDKN1C  3 0.527 2
 UniProt:Q08379 GOLGA2  3 0.527 2
 UniProt:Q14004 CDK13  3 0.527 2
 UniProt:O75496 GMNN  2 0.527 2
 UniProt:Q13616 CUL1  3 0.527 3
 UniProt:P12004 PCNA  5 0.527 2
 UniProt:Q9BY12 SCAPE      0.524 3
 UniProt:Q9UQR0 SCML2      0.499 3
 UniProt:Q8NA61-2 CBY2      0.488 2
 UniProt:Q8N448 LNX2      0.488 2
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