CDK2 [nucleoplasm]

Stable Identifier
R-HSA-68365
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cdk2, Cell division protein kinase 2 (EC 2.7.1.-)(p33 protein kinase)(CDK2), Cell division protein kinase 2 , p33 protein kinase
Icon
CDK2 [nucleoplasm] icon
CDK2 [nucleoplasm] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P24941 CDK2
Gene Names
CDK2, CDKN2
Chain
chain:1-298
Reference Genes
BioGPS Gene:1017 CDK2
COSMIC (genes):CDK2 CDK2
CTD Gene:1017 CDK2
dbSNP Gene:1017 CDK2
ENSEMBL:ENSG00000123374 CDK2
ENSEMBL_homo_sapiens_GENE:ENSG00000123374 CDK2
HGNC:1771 CDK2
KEGG Gene (Homo sapiens):1017 CDK2
Monarch:1017 CDK2
NCBI Gene:1017 CDK2
OMIM:116953 CDK2
UCSC:P24941 CDK2
Reference Transcript
Other Identifiers
0002190091
0004590162
1017
11720781_a_at
11720782_a_at
11741208_a_at
13115
16752305
1792_g_at
1833_at
1AQ1
1B38
1B39
1BUH
1CKP
1DI8
1DM2
1E1V
1E1X
1E9H
1F5Q
1FIN
1FQ1
1FVT
1FVV
1G5S
1GIH
1GII
1GIJ
1GY3
1GZ8
1H00
1H01
1H07
1H08
1H0V
1H0W
1H1P
1H1Q
1H1R
1H1S
1H24
1H25
1H26
1H27
1H28
1HCK
1HCL
1JST
1JSU
1JSV
1JVP
1KE5
1KE6
1KE7
1KE8
1KE9
1OGU
1OI9
1OIQ
1OIR
1OIT
1OIU
1OIY
1OKV
1OKW
1OL1
1OL2
1P2A
1P5E
1PF8
1PKD
1PW2
1PXI
1PXJ
1PXK
1PXL
1PXM
1PXN
1PXO
1PXP
1PYE
1QMZ
1R78
1URC
1URW
1V1K
1VYW
1VYZ
1W0X
1W8C
1W98
1WCC
1Y8Y
1Y91
1YKR
204252_at
211804_s_at
2A0C
2A4L
2B52
2B53
2B54
2B55
2BHE
2BHH
2BKZ
2BPM
2BTR
2BTS
2C4G
2C5N
2C5O
2C5V
2C5X
2C5Y
2C68
2C69
2C6I
2C6K
2C6L
2C6M
2C6O
2C6T
2CCH
2CCI
2CJM
2CLX
2DS1
2DUV
2EXM
2FVD
2G9X
2HIC
2I40
2IW6
2IW8
2IW9
2J9M
2JGZ
2R3F
2R3G
2R3H
2R3I
2R3J
2R3K
2R3L
2R3M
2R3N
2R3O
2R3P
2R3Q
2R3R
2R64
2UUE
2UZB
2UZD
2UZE
2UZL
2UZN
2UZO
2V0D
2V22
2VTA
2VTH
2VTI
2VTJ
2VTL
2VTM
2VTN
2VTO
2VTP
2VTQ
2VTR
2VTS
2VTT
2VU3
2VV9
2W05
2W06
2W17
2W1H
2WEV
2WFY
2WHB
2WIH
2WIP
2WMA
2WMB
2WPA
2WXV
2X1N
2XMY
2XNB
3417148
3417149
3417152
3417153
3417154
3417155
3417157
3417158
3417159
3417160
3BHT
3BHU
3BHV
3DDP
3DDQ
3DOG
3EID
3EJ1
3EOC
3EZR
3EZV
3F5X
3FZ1
3IG7
3IGG
3LE6
3LFN
3LFQ
3LFS
3MY5
3NS9
3PJ8
3PXF
3PXQ
3PXR
3PXY
3PXZ
3PY0
3PY1
3QHR
3QHW
3QL8
3QQF
3QQG
3QQH
3QQJ
3QQK
3QQL
3QRT
3QRU
3QTQ
3QTR
3QTS
3QTU
3QTW
3QTX
3QTZ
3QU0
3QWJ
3QWK
3QX2
3QX4
3QXO
3QXP
3QZF
3QZG
3QZH
3QZI
3R1Q
3R1S
3R1Y
3R28
3R6X
3R71
3R73
3R7E
3R7I
3R7U
3R7V
3R7Y
3R83
3R8L
3R8M
3R8P
3R8U
3R8V
3R8Z
3R9D
3R9H
3R9N
3R9O
3RAH
3RAI
3RAK
3RAL
3RJC
3RK5
3RK7
3RK9
3RKB
3RM6
3RM7
3RMF
3RNI
3ROY
3RPO
3RPR
3RPV
3RPY
3RZB
3S00
3S0O
3S1H
3S2P
3SQQ
3SW4
3SW7
3TI1
3TIY
3TIZ
3TNW
3ULI
3UNJ
3UNK
3WBL
4ACM
4BCK
4BCM
4BCN
4BCO
4BCP
4BCQ
4BGH
4BZD
4CFM
4CFN
4CFU
4CFV
4CFW
4CFX
4D1X
4D1Z
4EK3
4EK4
4EK5
4EK6
4EK8
4EOI
4EOJ
4EOK
4EOL
4EOM
4EON
4EOO
4EOP
4EOQ
4EOR
4EOS
4ERW
4EZ3
4EZ7
4FKG
4FKI
4FKJ
4FKL
4FKO
4FKP
4FKQ
4FKR
4FKS
4FKT
4FKU
4FKV
4FKW
4FX3
4GCJ
4I3Z
4II5
4KD1
4LYN
4NJ3
4RJ3
5A14
5AND
5ANE
5ANG
5ANI
5ANJ
5ANK
5ANO
5CYI
5D1J
5FP5
5FP6
5IEV
5IEX
5IEY
5IF1
5JQ5
5JQ8
5K4J
5L2W
5LMK
5MHQ
5NEV
5OO0
5OO1
5OO3
5OSJ
5OSM
5UQ1
5UQ2
5UQ3
66915
6ATH
74635_at
7956076
A0A024RB10
A0A024RB77
A_14_P122617
A_23_P98898
AAA35667
AAH03065
AAM34794
AAP35467
AB012305
AC025162
AC034102
AF512553
AK291941
BAA32794
BAF84630
BC003065
BT006821
CAA43807
CAA43985
CAB013115
CCDS8898
CCDS8899
CDK2
CDK2-201
CDK2-202
CH471054
E7ESI2
EAW96856
EAW96857
EAW96858
EAW96860
ENSG00000123374
ENSP00000243067
ENSP00000266970
ENST00000266970
ENST00000266970.8
ENST00000354056
ENST00000354056.4
EntrezGene:1017
g180177_3p_at
g3551190_3p_a_at
G3V317
G3V5T9
GE81070
GO:0000082
GO:0000086
GO:0000122
GO:0000166
GO:0000287
GO:0000307
GO:0000781
GO:0000793
GO:0000805
GO:0000806
GO:0003674
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005575
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005768
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006259
GO:0006260
GO:0006281
GO:0006464
GO:0006468
GO:0006810
GO:0006813
GO:0006950
GO:0006974
GO:0006977
GO:0007010
GO:0007049
GO:0007099
GO:0007165
GO:0007265
GO:0008284
GO:0009056
GO:0009058
GO:0010389
GO:0015030
GO:0016301
GO:0016310
GO:0016572
GO:0016740
GO:0018105
GO:0019904
GO:0022607
GO:0030332
GO:0031145
GO:0031410
GO:0031571
GO:0032298
GO:0032991
GO:0034641
GO:0035173
GO:0043167
GO:0043226
GO:0045893
GO:0046872
GO:0051298
GO:0051301
GO:0051321
GO:0051726
GO:0060968
GO:0071732
GO:0097123
GO:0097124
GO:0097134
GO:0097135
GO:0097472
GO:1901796
HGNC:1771
HPA066915
ILMN_1653443
ILMN_1665559
IPR000719
IPR008271
IPR011009
IPR017441
M68520
M68520_at
MIM:116953
NM_001798
NM_052827
NP_001789
NP_439892
PF00069
PH_hs_0001687
SM00220
TC12000496.hg
UPI00001105FA
UPI000013CB21
X61622
X62071
Participant Of
hasComponent
input
Other forms of this molecule
p-CDK2 [nucleoplasm]
CDK2 [cytosol]
p-Y15-CDK2 [nucleoplasm]
p-T160-CDK2 [nucleoplasm]
Inferred To
CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Canis familiaris)
CDK2 [nucleoplasm] (Danio rerio)
CDK2 [nucleoplasm] (Dictyostelium discoideum)
CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Gallus gallus)
CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Plasmodium falciparum)
CDK2 [nucleoplasm] (Rattus norvegicus)
CDK2 [nucleoplasm] (Saccharomyces cerevisiae)
CDK2 [nucleoplasm] (Schizosaccharomyces pombe)
CDK2 [nucleoplasm] (Sus scrofa)
CDK2 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
4I3Z, 3RAI, 4FKO, 2C4G, 1PXL, 4ERW, 3R1Y, 2R3G, 2JGZ, 1PXO, 1PF8, 1B38, 2VTR, 2UZB, 4BGH, 2VTO, 6ATH, 1H25, 3QQG, 2R3R, 3R8M, 5IEY, 1OL1, 1H28, 3RMF, 1H00, 3R8V, 2WMB, 2UUE, 2C5N, 4EZ3, 5ANI, 1FVV, 1URW, 4CFM, 4EOK, 2C6O, 5ANO, 2BTR, 3QZI, 3QTX, 6GUK, 3LFQ, 2R64, 3PY0, 4CFV, 1KE6, 6GUE, 2WPA, 5FP6, 3QZF, 3QTS, 3PXR, 4FKL, 1PXM, 3R1Q, 3RAL, 4FKQ, 1DI8, 1OKV, 1H26, 5MHQ, 2VTP, 3EID, 3R71, 3RPO, 2VTM, 5D1J, 3UNK, 1OL2, 1PXJ, 2R3P, 3DOG, 4FX3, 3R8U, 3IG7, 1H1S, 4EOJ, 3R9D, 5ANK, 6GUH, 2BTS, 3TNW, 2C6T, 1HCK, 2CJM, 4EOM, 2C6L, 3PXY, 4CFU, 3QTU, 3QZG, 5FP5, 3SW7, 4CFX, 3R1S, 3QTQ, 2CLX, 2HIC, 3BHV, 5NEV, 4FKP, 1G5S, 3PXF, 4RJ3, 1GIJ, 3ROY, 3EJ1, 3RJC, 4FKS, 1OKW, 3UNJ, 3R6X, 3LE6, 1PXK, 2R3Q, 2VTN, 3QHW, 4ACM, 1Y91, 3QXO, 2VTJ, 3FZ1, 1FVT, 1H1Q, 5JQ8, 3RPV, 2WIP, 2R3N, 3R7E, 2J9M, 3R8Z, 1H24, 2WMA, 4EZ7, 3QL8, 5OO0, 4EOL, 1HCL, 3EZV, 2C6M, 3R9N, 1F5Q, 1PW2, 4EOO, 3DDQ, 4BCM, 2C6I, 4CFW, 1FQ1, 3QTR, 1GIH, 3PXQ, 4GCJ, 1OIU, 3BHT, 1E9H, 1PXI, 4FKR, 5JQ5, 4FKU, 3QXP, 3R73, 5L2W, 3RPR, 2R3O, 1W8C, 3RK7, 2VTL, 1H1R, 2VTH, 5UQ2, 3QRT, 3NS9, 2R3L, 2B54, 3QX2, 1OIY, 3MY5, 3R7U, 3R9H, 5OO3, 2W17, 4KD1, 4BZD, 2BPM, 5LMK, 4EON, 2UZO, 1VYZ, 1OIR, 2WHB, 4II5, 4BCK, 2C6K, 2BKZ, 1GII, 4EOQ, 4BCO, 2IW8, 1H0W, 4EK4, 2C68, 1Y8Y, 3BHU, 2G9X, 4FKT, 3S0O, 1E1X, 5CYI, 4FKW, 3RK5, 3QHR, 3QRU, 1W98, 3RPY, 5UQ1, 2R3M, 2WIH, 2CCH, 2WXV, 2VTI, 3R7I, 2B55, 3RKB, 3QX4, 2W1H, 2R3J, 1GZ8, 1JSV, 2VU3, 5OO1, 3QWJ, 1H1P, 3EZR, 3R7Y, 4NJ3, 3R9O, 1OIT, 3QQK, 4EOP, 2UZL, 4EK3, 2V22, 4BCN, 2B52, 3DDP, 3TI1, 2IW9, 3S00, 1JVP, 2EXM, 4EOS, 4BCQ, 3F5X, 2C69, 1H08, 2W05, 5K4J, 4EK6, 1OI9, 2C5X, 5AND, 4FKV, 4D1Z, 3RK9, 2WEV, 2VV9, 1KE9, 2CCI, 1JST, 4FKG, 2VTA, 5UQ3, 1P2A, 2R3K, 1PXP, 1B39, 3RZB, 3R7V, 3RAH, 3QWK, 2I40, 2R3H, 2VTS, 1P5E, 3QQL, 1H0V, 2UZN, 3S2P, 2B53, 2UZD, 2BHE, 3QQH, 4EOR, 5IEX, 3R8L, 3RM7, 4EK5, 4BCP, 2IW6, 2W06, 1E1V, 5OSM, 1DM2, 1VYW, 1OIQ, 2C5Y, 2WFY, 4D1X, 2A4L, 6GUC, 5ANG, 3TIZ, 1YKR, 1KE7, 2A0C, 1H01, 3QTZ, 1BUH, 2C5O, 2XMY, 3LFS, 3EOC, 3S1H, 1JSU, 1FIN, 1R78, 1PYE, 4FKJ, 2R3I, 5IEV, 3R83, 3RAK, 2R3F, 3R28, 2VTT, 2VTQ, 2DS1, 5OSJ, 2UZE, 2BHH, 5IF1, 3QQJ, 2FVD, 1V1K, 1PXN, 3RM6, 3IGG, 3PY1, 1H07, 3QQF, 5A14, 1AQ1, 3R8P, 2DUV, 1H27, 1GY3, 1CKP, 4EK8, 3TIY, 1KE8, 6GUB, 2C5V, 3WBL, 1PKD, 5ANE, 1URC, 4EOI, 5ANJ, 2X1N, 1W0X, 2XNB, 4CFN, 2V0D, 3SQQ, 3QU0, 3ULI, 3RNI, 4LYN, 3PJ8, 1WCC, 1QMZ, 3QTW, 3PXZ, 3QZH, 3LFN, 4FKI, 6GUF, 3SW4, 1KE5, 1OGU
ZINC - Metabolites
IntEnz
GeneCards
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (37)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P38936 CDKN1A  5 0.973 27
 UniProt:P20248 CCNA2  3 0.971 25
 UniProt:P46527 CDKN1B  8 0.967 23
 UniProt:P24864 CCNE1  3 0.957 20
 UniProt:P61024 CKS1B  1 0.938 20
 UniProt:O96020 CCNE2  3 0.916 10
 UniProt:Q16667 CDKN3      0.889 8
 UniProt:Q13309 SKP2  2 0.788 7
 UniProt:Q08999 RBL2  2 0.758 5
 UniProt:Q96PU4 UHRF2  1 0.729 5
 UniProt:P14635 CCNB1  4 0.725 6
 UniProt:P50613 CDK7  1 0.713 3
 UniProt:O95067 CCNB2  1 0.702 3
 UniProt:P51946 CCNH  1 0.693 3
 UniProt:P24385 CCND1  4 0.659 3
 UniProt:P33552 CKS2      0.643 3
 UniProt:P63208 SKP1  2 0.643 4
 UniProt:Q9H211 CDT1  2 0.643 3
 UniProt:P28749 RBL1  2 0.643 4
 UniProt:Q09472 EP300  5 0.641 5
 UniProt:Q9Y6K9 IKBKG  12 0.633 4
 UniProt:Q8TD08 MK15      0.623 4
 UniProt:P06400 RB1  3 0.623 3
 UniProt:Q9UQR0-1 SCML2      0.612 7
 UniProt:O95835 LATS1  2 0.576 4
 UniProt:P03129 VE7      0.564 2
 UniProt:Q99523 SORT1  2 0.564 2
 UniProt:P51943 Ccna2  4 0.558 2
 UniProt:P30274 CCNA2      0.544 2
 UniProt:Q08619 IFI5B      0.544 2
 UniProt:P49918 CDKN1C  3 0.527 2
 UniProt:Q92793 CREBBP  3 0.527 2
 UniProt:Q08379 GOLGA2  3 0.527 2
 UniProt:Q14004 CDK13  3 0.527 2
 UniProt:Q9UQR0 SCML2      0.499 3
 UniProt:Q8NA61-2 SPERT      0.488 2
 UniProt:Q8N448 LNX2      0.488 2