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CDK2 [nucleoplasm]
Stable Identifier
R-HSA-68365
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cdk2, Cell division protein kinase 2 (EC 2.7.1.-)(p33 protein kinase)(CDK2), Cell division protein kinase 2 , p33 protein kinase
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Activation of claspin (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Loading of claspin onto DNA during replication origin firing (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G0 and Early G1 (Homo sapiens)
p107 (RBL1) binds CyclinE/A:CDK2 (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
RBL1:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
RBL1:E2F4:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
p130 (RBL2) binds Cyclin E/A:CDK2 (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
RBL2:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
CAK-mediated phosphorylation of Cyclin E:Cdk2 (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Translocation of Cyclin E:Cdk2 complex to the nucleus (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cyclin A:Cdk2:phospho-p27/p21 complex [nucleoplasm] (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Translocation of Cyclin A:Cdk2 complexes to the nucleus (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Resolution of meiotic holliday junction (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cleaved Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
CEBPA binds CDK2 (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
CEBPA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Cables1 links CDK2 and WEE1 (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
CDK2:CABLES1:WEE1 [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Resolution of meiotic holliday junction (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
Cleaved Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
CDK2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24941 CDK2
Gene Names
CDK2, CDKN2
Chain
chain:1-298
Reference Genes
BioGPS Gene:1017 CDK2
COSMIC (genes):CDK2 CDK2
CTD Gene:1017 CDK2
dbSNP Gene:1017 CDK2
ENSEMBL:ENSG00000123374 CDK2
ENSEMBL_homo_sapiens_GENE:ENSG00000123374.11 CDK2
HGNC:1771 CDK2
KEGG Gene (Homo sapiens):1017 CDK2
Monarch:1017 CDK2
NCBI Gene:1017 CDK2
OMIM:116953 CDK2
UCSC:P24941 CDK2
Reference Transcript
RefSeq:NM_001290230.1 CDK2
RefSeq:NM_001798.4 CDK2
RefSeq:NM_052827.3 CDK2
Other Identifiers
1017
11720781_a_at
11720782_a_at
11741208_a_at
16752305
1792_g_at
1833_at
204252_PM_at
204252_at
211804_PM_s_at
211804_s_at
3417147
3417148
3417149
3417152
3417153
3417154
3417155
3417157
3417158
3417159
3417160
74635_at
7956076
A_14_P122617
A_14_P129989
A_23_P98898
GE724134
GE81070
GO:0000082
GO:0000086
GO:0000122
GO:0000166
GO:0000278
GO:0000287
GO:0000307
GO:0000781
GO:0000793
GO:0000805
GO:0000806
GO:0001673
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005634
GO:0005635
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005768
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006260
GO:0006281
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006468
GO:0006813
GO:0006974
GO:0007010
GO:0007049
GO:0007099
GO:0007165
GO:0007265
GO:0007346
GO:0008284
GO:0010033
GO:0010389
GO:0010468
GO:0015030
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0019904
GO:0022414
GO:0023052
GO:0030163
GO:0030332
GO:0031410
GO:0031453
GO:0031571
GO:0032298
GO:0035173
GO:0036211
GO:0043226
GO:0043687
GO:0045740
GO:0045893
GO:0046872
GO:0051298
GO:0051301
GO:0051321
GO:0071732
GO:0090398
GO:0097123
GO:0097124
GO:0097134
GO:0097135
GO:0097472
GO:0106310
GO:0140096
GO:1905784
HMNXSV003002576
ILMN_1653443
ILMN_1665559
M68520_at
PH_hs_0001687
TC12000496.hg
g180177_3p_at
g3551190_3p_a_at
Participates
as a component of
CDK2:CABLES1:WEE1 [nucleoplasm] (Homo sapiens)
CEBPA:CDK2 [nucleoplasm] (Homo sapiens)
Cleaved Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
CCNA:CDK2 [nucleoplasm] (Homo sapiens)
CDK [nucleoplasm] (Homo sapiens)
as an input of
Cables1 links CDK2 and WEE1 (Homo sapiens)
CEBPA binds CDK2 (Homo sapiens)
Resolution of meiotic holliday junction (Homo sapiens)
Other forms of this molecule
p-Y15-CDK2 [nucleoplasm]
p-CDK2 [nucleoplasm]
CDK2 [cytosol]
p-T160-CDK2 [nucleoplasm]
Inferred To
CDK2 [nucleoplasm]
(Bos taurus)
CDK2 [nucleoplasm]
(Caenorhabditis elegans)
CDK2 [nucleoplasm]
(Canis familiaris)
CDK2 [nucleoplasm]
(Danio rerio)
CDK2 [nucleoplasm]
(Dictyostelium discoideum)
CDK2 [nucleoplasm]
(Drosophila melanogaster)
CDK2 [nucleoplasm]
(Gallus gallus)
CDK2 [nucleoplasm]
(Mus musculus)
CDK2 [nucleoplasm]
(Plasmodium falciparum)
CDK2 [nucleoplasm]
(Rattus norvegicus)
CDK2 [nucleoplasm]
(Saccharomyces cerevisiae)
CDK2 [nucleoplasm]
(Schizosaccharomyces pombe)
CDK2 [nucleoplasm]
(Sus scrofa)
CDK2 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001277159.1
,
NP_439892.2
,
NP_001789.2
ZINC - World Drugs
CDK2_HUMAN
Guide to Pharmacology - Targets
1973
OpenTargets
ENSG00000123374
ZINC - FDA approved
CDK2_HUMAN
ZINC - Substances
CDK2_HUMAN
ZINC - Biogenic
CDK2_HUMAN
ZINC target
P24941
PRO
P24941
PDB
4I3Z
,
3R1Y
,
1OIR
,
3SQQ
,
1DM2
,
8FP5
,
8BYA
,
3S00
,
1OKV
,
3R9D
,
1CKP
,
2WMA
,
2R3Q
,
8ERD
,
2UZL
,
4EOL
,
2X1N
,
6GUC
,
7B5R
,
2W17
,
2VTL
,
6YL6
,
3RMF
,
3LE6
,
8UV0
,
4EK6
,
2BHH
,
3R7E
,
1KE6
,
2VTQ
,
7NVQ
,
4ACM
,
3RK9
,
1PXO
,
6Q49
,
3QQK
,
1Y8Y
,
3F5X
,
6RIJ
,
2CJM
,
4GCJ
,
4BCO
,
4CFV
,
1PYE
,
1URC
,
7S85
,
5UQ1
,
3LFN
,
6Q4E
,
4EOP
,
6GUK
,
5OSJ
,
4FKS
,
1B39
,
4RJ3
,
8BZO
,
3ULI
,
3FZ1
,
7ACK
,
1E9H
,
1PXK
,
3EID
,
1OKW
,
3R9H
,
4FKV
,
5MHQ
,
3QL8
,
2VTO
,
8H6P
,
1WCC
,
7UXI
,
5L2W
,
5AND
,
1PXM
,
7MKX
,
3QQF
,
3QZI
,
8OR0
,
4FKO
,
7RWF
,
2VTI
,
4KD1
,
1URW
,
3R8P
,
5ANJ
,
2C6I
,
1OIT
,
1R78
,
3R7I
,
2J9M
,
6Q4J
,
2IW6
,
4EK8
,
3UNJ
,
2B52
,
1PXI
,
4EZ3
,
2B54
,
1H1P
,
1W0X
,
3PXY
,
4FKG
,
1AQ1
,
5IEY
,
1H24
,
3WBL
,
2WMB
,
3R7Y
,
4BCP
,
3QWK
,
4CFW
,
3SW4
,
6Q4A
,
7B7S
,
3QXP
,
8ERN
,
4EK3
,
2VV9
,
6Q3B
,
1BUH
,
3TI1
,
3RAK
,
4FKT
,
2VTA
,
4FX3
,
2JGZ
,
4CFM
,
5D1J
,
4BCK
,
2C5O
,
7VDU
,
3QX2
,
6YLK
,
4FKW
,
2C68
,
6GUE
,
3TIY
,
2WFY
,
3RPV
,
4FKP
,
2C5X
,
2C6L
,
3QZF
,
1OGU
,
3R8U
,
2XMY
,
2UZD
,
3IG7
,
2WHB
,
2C4G
,
3QTX
,
3RNI
,
1H1Q
,
2DUV
,
1JSV
,
1H25
,
8H6T
,
4EZ7
,
3QTR
,
3PXZ
,
2R3O
,
6GVA
,
4FKI
,
3R6X
,
8OR4
,
2A0C
,
7S9X
,
3R83
,
2C6O
,
3SW7
,
6Q4F
,
3PXF
,
5UQ2
,
7SA0
,
1H07
,
1JVP
,
5OSM
,
2BTR
,
1FVT
,
2R3R
,
1E1V
,
6SG4
,
2R3K
,
8OY2
,
2CCH
,
3EOC
,
2W1H
,
3ROY
,
6Q4K
,
7RXO
,
2R3I
,
2WXV
,
2R3G
,
2VTM
,
3RPY
,
3IGG
,
4D1X
,
4EOM
,
5ANE
,
3EZR
,
7RA5
,
6Q3C
,
1FVV
,
7ZPC
,
7UXK
,
5ANK
,
2R3M
,
6ATH
,
3S0O
,
5JQ5
,
3R28
,
3RAL
,
4EOQ
,
3EJ1
,
3QQL
,
3QTS
,
4EOI
,
5IF1
,
3QQG
,
1KE7
,
6JGM
,
6Q4B
,
2UUE
,
2UZN
,
4BZD
,
2FVD
,
1H08
,
3BHT
,
3RKB
,
3QTZ
,
1VYZ
,
5NEV
,
3R9N
,
4II5
,
3RM6
,
7UG1
,
2VTP
,
1OL1
,
8VQ3
,
3R1Q
,
2W05
,
3S1H
,
2BKZ
,
2VTS
,
1W8C
,
3RJC
,
3LFQ
,
6GUF
,
2WPA
,
3MY5
,
4EON
,
6Q4G
,
3RZB
,
1YKR
,
1PXP
,
4EOR
,
3UNK
,
2CLX
,
5OO0
,
1KE8
,
1Y91
,
3QQH
,
3RK5
,
1OIU
,
2BHE
,
4EOJ
,
8FOW
,
3EZV
,
5LMK
,
3QRT
,
3DDP
,
4BCQ
,
1OI9
,
3R7U
,
3R8V
,
2VTR
,
4CFX
,
8CUR
,
2VTJ
,
4EK4
,
1GII
,
5UQ3
,
5ANO
,
3R9O
,
3R8L
,
3TNW
,
1OIQ
,
7KJS
,
1DI8
,
4FKU
,
4BCM
,
4CFN
,
2I40
,
4BGH
,
1PXJ
,
2WIH
,
1H00
,
4FKJ
,
2XNB
,
4LYN
,
6Q4C
,
1PXL
,
5ANG
,
1OL2
,
3QZG
,
8VQ4
,
3LFS
,
3TIZ
,
2UZE
,
6Q3F
,
5JQ8
,
4FKQ
,
1PXN
,
3PJ8
,
2B53
,
1H1R
,
1FIN
,
1HCK
,
7S4T
,
2IW8
,
5IEV
,
2VTN
,
3QX4
,
3PY0
,
1OIY
,
5CYI
,
7M2F
,
6OQI
,
3DOG
,
3R71
,
3PXQ
,
3R8Z
,
3DDQ
,
1H26
,
3R7V
,
2B55
,
2A4L
,
1V1K
,
1B38
,
5FP5
,
4NJ3
,
2V0D
,
4EK5
,
2UZB
,
3QU0
,
3R8M
,
2IW9
,
2C5V
,
2WIP
,
6Q4H
,
3RAH
,
2R64
,
2C6K
,
2C5N
,
2C6T
,
4BCN
,
7E34
,
3R73
,
4CFU
,
4FKL
,
1PKD
,
1H0V
,
2C69
,
3QZH
,
1GIH
,
4D1Z
,
6GUH
,
2VTH
,
2C5Y
,
2C6M
,
3RPO
,
3QHR
,
4FKR
,
1PW2
,
3S2P
,
3QTU
,
5A14
,
1GY3
,
1F5Q
,
2UZO
,
5K4J
,
2R3H
,
3PY1
,
1JST
,
1HCL
,
5OO1
,
8FP0
,
1H1S
,
6Q48
,
1P2A
,
6GUB
,
2BTS
,
2VTT
,
3PXR
,
3QWJ
,
1H27
,
1PF8
,
3QXO
,
2CCI
,
6YL1
,
8B54
,
3BHU
,
3RM7
,
7S7A
,
2R3J
,
3R1S
,
3RAI
,
2W06
,
6P3W
,
7B5L
,
2WEV
,
3QRU
,
1E1X
,
2R3N
,
4EOK
,
7S84
,
3NS9
,
1H0W
,
6INL
,
1H28
,
2G9X
,
5ANI
,
2R3L
,
2BPM
,
2EXM
,
3QHW
,
3RPR
,
6Q4D
,
2R3F
,
1P5E
,
1KE5
,
1QMZ
,
3QTW
,
1W98
,
5FP6
,
1GZ8
,
2V22
,
2DS1
,
4EOS
,
6Q4I
,
3QQJ
,
3RK7
,
1KE9
,
7QHL
,
2R3P
,
3QTQ
,
1JSU
,
5IEX
,
2VU3
,
1FQ1
,
5OO3
,
1VYW
,
7RWE
,
3BHV
,
4ERW
,
1G5S
,
1GIJ
,
1H01
,
4EOO
ZINC - Investigational
CDK2_HUMAN
ZINC - Metabolites
CDK2_HUMAN
GeneCards
P24941
HPA
ENSG00000123374-CDK2
Ensembl
ENST00000266970
,
ENSG00000123374
,
ENST00000354056
,
ENSP00000243067
,
ENSP00000266970
Pharos - Targets
P24941
ZINC - Predictions - Purchasable
CDK2_HUMAN
HMDB Protein
HMDBP01383
Interactors (57)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.977
33
UniProt:P38936 CDKN1A
5
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
0.976
32
UniProt:P46527 CDKN1B
8
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
CDKN1B [cytosol]
(R-HSA-198622)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
0.974
31
UniProt:P24864 CCNE1
3
CCNE1 [nucleoplasm]
(R-HSA-68363)
CCNE1 [cytosol]
(R-HSA-157443)
Unfolded CCNE1 [cytosol]
(R-HSA-6813836)
0.966
26
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.949
28
UniProt:O96020 CCNE2
3
Unfolded CCNE2 [cytosol]
(R-HSA-6813844)
CCNE2 [cytosol]
(R-HSA-157452)
CCNE2 [nucleoplasm]
(R-HSA-68367)
0.937
15
UniProt:Q16667 CDKN3
0.92
10
UniProt:Q08999 RBL2
2
RBL2 [nucleoplasm]
(R-HSA-389102)
p-T401,S672,S1035-RBL2 [nucleoplasm]
(R-HSA-1226084)
0.892
10
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [nucleoplasm]
(R-HSA-975554)
0.892
12
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.877
11
UniProt:P24385 CCND1
4
CCND1 [nucleoplasm]
(R-HSA-113832)
CCND1 [cytosol]
(R-HSA-68328)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
0.845
8
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.837
9
UniProt:O95067 CCNB2
1
CCNB2 [cytosol]
(R-HSA-68897)
0.822
6
UniProt:P51946 CCNH
1
CCNH [nucleoplasm]
(R-HSA-69220)
0.818
6
UniProt:P33552 CKS2
0.788
7
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.784
7
UniProt:Q96PU4 UHRF2
1
UHRF2 [nucleoplasm]
(R-HSA-976050)
0.729
5
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.725
6
UniProt:P30281 CCND3
2
CCND3 [cytosol]
(R-HSA-68333)
CCND3 [nucleoplasm]
(R-HSA-113835)
0.725
7
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.725
5
UniProt:P50613 CDK7
1
CDK7 [nucleoplasm]
(R-HSA-69218)
0.713
3
UniProt:Q8TD08 MK15
0.708
6
UniProt:P30279 CCND2
2
CCND2 [cytosol]
(R-HSA-68340)
CCND2 [nucleoplasm]
(R-HSA-113827)
0.659
4
UniProt:Q00526 CDK3
0.643
6
UniProt:P49918 CDKN1C
3
p-Y91-CDKN1C [cytosol]
(R-HSA-8942606)
CDKN1C [cytosol]
(R-HSA-8941913)
CDKN1C [nucleoplasm]
(R-HSA-8948130)
0.643
5
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.643
4
UniProt:O75496 GMNN
2
GMNN [nucleoplasm]
(R-HSA-113554)
PolyUb-GMNN [nucleoplasm]
(R-HSA-68585)
0.643
4
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.643
4
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.643
4
UniProt:Q9H211 CDT1
1
CDT1 [nucleoplasm]
(R-HSA-68536)
0.643
3
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.633
4
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.623
3
UniProt:Q9UQR0-1 SCML2
0.612
7
UniProt:O95835 LATS1
2
LATS1 [cytosol]
(R-HSA-2028562)
p-S909,T1079-LATS1 [cytosol]
(R-HSA-2028551)
0.576
4
UniProt:P03129 VE7
0.564
2
UniProt:Q99523 SORT1
2
SORT1 [cytoplasmic vesicle membrane]
(R-HSA-434221)
SORT1 [Golgi membrane]
(R-HSA-434332)
0.564
2
UniProt:P51943 Ccna2
4
Ccna2 [nucleoplasm]
(R-MMU-6783099)
Ccna2 [nucleoplasm]
(R-MMU-1362307)
Ccna2 [cytosol]
(R-MMU-157444)
Ccna2 [nucleoplasm]
(R-MMU-68905)
0.558
2
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
0.556
3
UniProt:P01112 HRAS
20
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
0.556
3
UniProt:Q14957 GRIN2C
3
GRIN2C [plasma membrane]
(R-HSA-419560)
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:P30274 CCNA2
0.544
2
UniProt:Q08619 IFI5B
0.544
2
UniProt:Q16254 E2F4
1
E2F4 [nucleoplasm]
(R-HSA-68664)
0.527
2
UniProt:Q5T5M9 CCNJ
0.527
2
UniProt:P49918-2 CDKN1C
0.527
2
UniProt:Q86YS7 C2CD5
2
p-S197-C2CD5 [plasma membrane]
(R-HSA-5260194)
C2CD5 [plasma membrane]
(R-HSA-5216175)
0.527
2
UniProt:Q00536 CDK16
0.527
2
UniProt:Q9Y3Z3 SAMHD1
1
SAMHD1 [nucleoplasm]
(R-HSA-5624198)
0.527
3
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.527
3
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.527
2
UniProt:Q14004 CDK13
3
CDK13 [nucleoplasm]
(R-HSA-6797014)
CDK13 [ficolin-1-rich granule lumen]
(R-HSA-6801374)
CDK13 [extracellular region]
(R-HSA-6806442)
0.527
2
UniProt:Q15078 CDK5R1
4
MyrG-CDK5R1(2-307) [plasma membrane]
(R-HSA-421083)
CDK5R1(99-307) [nucleoplasm]
(R-HSA-6805262)
CDK5R1(99-307) [cytosol]
(R-HSA-8863415)
MyrG-CDK5R1(2-98) [plasma membrane]
(R-HSA-8863400)
0.527
2
UniProt:Q9BY12 SCAPE
0.524
3
UniProt:Q9UQR0 SCML2
0.499
3
UniProt:Q8NA61-2 CBY2
0.488
2
UniProt:Q8N448 LNX2
0.488
2
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