Reactome | p-CDK2 [nucleoplasm]

p-CDK2 [nucleoplasm]

Stable Identifier

R-HSA-68370

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

phospho-Cdk2, Cell division protein kinase 2 , p33 protein kinase

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External Reference Information

External Reference

UniProt:P24941 CDK2

Gene Names

CDK2, CDKN2

Chain

chain:1-298

Reference Genes

BioGPS Gene:1017 CDK2

COSMIC (genes):CDK2 CDK2

CTD Gene:1017 CDK2

dbSNP Gene:1017 CDK2

ENSEMBL:ENSG00000123374 CDK2

ENSEMBL_homo_sapiens_GENE:ENSG00000123374 CDK2

HGNC:1771 CDK2

KEGG Gene (Homo sapiens):1017 CDK2

Monarch:1017 CDK2

NCBI Gene:1017 CDK2

OMIM:116953 CDK2

UCSC:P24941 CDK2

Reference Transcript

Other Identifiers

0002190091

0004590162

1017

11720781_a_at

11720782_a_at

11741208_a_at

13115

16752305

1792_g_at

1833_at

1AQ1

1B38

1B39

1BUH

1CKP

1DI8

1DM2

1E1V

1E1X

1E9H

1F5Q

1FIN

1FQ1

1FVT

1FVV

1G5S

1GIH

1GII

1GIJ

1GY3

1GZ8

1H00

1H01

1H07

1H08

1H0V

1H0W

1H1P

1H1Q

1H1R

1H1S

1H24

1H25

1H26

1H27

1H28

1HCK

1HCL

1JST

1JSU

1JSV

1JVP

1KE5

1KE6

1KE7

1KE8

1KE9

1OGU

1OI9

1OIQ

1OIR

1OIT

1OIU

1OIY

1OKV

1OKW

1OL1

1OL2

1P2A

1P5E

1PF8

1PKD

1PW2

1PXI

1PXJ

1PXK

1PXL

1PXM

1PXN

1PXO

1PXP

1PYE

1QMZ

1R78

1URC

1URW

1V1K

1VYW

1VYZ

1W0X

1W8C

1W98

1WCC

1Y8Y

1Y91

1YKR

204252_at

211804_s_at

2A0C

2A4L

2B52

2B53

2B54

2B55

2BHE

2BHH

2BKZ

2BPM

2BTR

2BTS

2C4G

2C5N

2C5O

2C5V

2C5X

2C5Y

2C68

2C69

2C6I

2C6K

2C6L

2C6M

2C6O

2C6T

2CCH

2CCI

2CJM

2CLX

2DS1

2DUV

2EXM

2FVD

2G9X

2HIC

2I40

2IW6

2IW8

2IW9

2J9M

2JGZ

2R3F

2R3G

2R3H

2R3I

2R3J

2R3K

2R3L

2R3M

2R3N

2R3O

2R3P

2R3Q

2R3R

2R64

2UUE

2UZB

2UZD

2UZE

2UZL

2UZN

2UZO

2V0D

2V22

2VTA

2VTH

2VTI

2VTJ

2VTL

2VTM

2VTN

2VTO

2VTP

2VTQ

2VTR

2VTS

2VTT

2VU3

2VV9

2W05

2W06

2W17

2W1H

2WEV

2WFY

2WHB

2WIH

2WIP

2WMA

2WMB

2WPA

2WXV

2X1N

2XMY

2XNB

3417148

3417149

3417152

3417153

3417154

3417155

3417157

3417158

3417159

3417160

3BHT

3BHU

3BHV

3DDP

3DDQ

3DOG

3EID

3EJ1

3EOC

3EZR

3EZV

3F5X

3FZ1

3IG7

3IGG

3LE6

3LFN

3LFQ

3LFS

3MY5

3NS9

3PJ8

3PXF

3PXQ

3PXR

3PXY

3PXZ

3PY0

3PY1

3QHR

3QHW

3QL8

3QQF

3QQG

3QQH

3QQJ

3QQK

3QQL

3QRT

3QRU

3QTQ

3QTR

3QTS

3QTU

3QTW

3QTX

3QTZ

3QU0

3QWJ

3QWK

3QX2

3QX4

3QXO

3QXP

3QZF

3QZG

3QZH

3QZI

3R1Q

3R1S

3R1Y

3R28

3R6X

3R71

3R73

3R7E

3R7I

3R7U

3R7V

3R7Y

3R83

3R8L

3R8M

3R8P

3R8U

3R8V

3R8Z

3R9D

3R9H

3R9N

3R9O

3RAH

3RAI

3RAK

3RAL

3RJC

3RK5

3RK7

3RK9

3RKB

3RM6

3RM7

3RMF

3RNI

3ROY

3RPO

3RPR

3RPV

3RPY

3RZB

3S00

3S0O

3S1H

3S2P

3SQQ

3SW4

3SW7

3TI1

3TIY

3TIZ

3TNW

3ULI

3UNJ

3UNK

3WBL

4ACM

4BCK

4BCM

4BCN

4BCO

4BCP

4BCQ

4BGH

4BZD

4CFM

4CFN

4CFU

4CFV

4CFW

4CFX

4D1X

4D1Z

4EK3

4EK4

4EK5

4EK6

4EK8

4EOI

4EOJ

4EOK

4EOL

4EOM

4EON

4EOO

4EOP

4EOQ

4EOR

4EOS

4ERW

4EZ3

4EZ7

4FKG

4FKI

4FKJ

4FKL

4FKO

4FKP

4FKQ

4FKR

4FKS

4FKT

4FKU

4FKV

4FKW

4FX3

4GCJ

4I3Z

4II5

4KD1

4LYN

4NJ3

4RJ3

5A14

5AND

5ANE

5ANG

5ANI

5ANJ

5ANK

5ANO

5CYI

5D1J

5FP5

5FP6

5IEV

5IEX

5IEY

5IF1

5JQ5

5JQ8

5K4J

5L2W

5LMK

5MHQ

5NEV

5OO0

5OO1

5OO3

5OSJ

5OSM

5UQ1

5UQ2

5UQ3

66915

6ATH

74635_at

7956076

A0A024RB10

A0A024RB77

A_14_P122617

A_23_P98898

AAA35667

AAH03065

AAM34794

AAP35467

AB012305

AC025162

AC034102

AF512553

AK291941

BAA32794

BAF84630

BC003065

BT006821

CAA43807

CAA43985

CAB013115

CCDS8898

CCDS8899

CDK2

CDK2-201

CDK2-202

CH471054

E7ESI2

EAW96856

EAW96857

EAW96858

EAW96860

ENSG00000123374

ENSP00000243067

ENSP00000266970

ENST00000266970

ENST00000266970.8

ENST00000354056

ENST00000354056.4

EntrezGene:1017

g180177_3p_at

g3551190_3p_a_at

G3V317

G3V5T9

GE81070

GO:0000082

GO:0000086

GO:0000122

GO:0000166

GO:0000287

GO:0000307

GO:0000781

GO:0000793

GO:0000805

GO:0000806

GO:0003674

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005768

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006259

GO:0006260

GO:0006281

GO:0006464

GO:0006468

GO:0006810

GO:0006813

GO:0006950

GO:0006974

GO:0006977

GO:0007010

GO:0007049

GO:0007099

GO:0007165

GO:0007265

GO:0008284

GO:0009056

GO:0009058

GO:0010389

GO:0015030

GO:0016301

GO:0016310

GO:0016572

GO:0016740

GO:0018105

GO:0019904

GO:0022607

GO:0030332

GO:0031145

GO:0031410

GO:0031571

GO:0032298

GO:0032991

GO:0034641

GO:0035173

GO:0043167

GO:0043226

GO:0045893

GO:0046872

GO:0051298

GO:0051301

GO:0051321

GO:0051726

GO:0060968

GO:0071732

GO:0097123

GO:0097124

GO:0097134

GO:0097135

GO:0097472

GO:1901796

HGNC:1771

HPA066915

ILMN_1653443

ILMN_1665559

IPR000719

IPR008271

IPR011009

IPR017441

M68520

M68520_at

MIM:116953

NM_001798

NM_052827

NP_001789

NP_439892

PF00069

PH_hs_0001687

SM00220

TC12000496.hg

UPI00001105FA

UPI000013CB21

X61622

X62071

Participant Of

hasComponent

Cyclin E:p-CDK2 [nucleoplasm]

Other forms of this molecule

CDK2 [cytosol]

p-Y15-CDK2 [nucleoplasm]

CDK2 [nucleoplasm]

p-T160-CDK2 [nucleoplasm]

Inferred To

phospho-p-CDK2 [nucleoplasm] (Bos taurus)

phospho-p-CDK2 [nucleoplasm] (Canis familiaris)

phospho-p-CDK2 [nucleoplasm] (Danio rerio)

phospho-p-CDK2 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-CDK2 [nucleoplasm] (Drosophila melanogaster)

phospho-p-CDK2 [nucleoplasm] (Gallus gallus)

phospho-p-CDK2 [nucleoplasm] (Mus musculus)

phospho-p-CDK2 [nucleoplasm] (Plasmodium falciparum)

phospho-p-CDK2 [nucleoplasm] (Rattus norvegicus)

phospho-p-CDK2 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-CDK2 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-p-CDK2 [nucleoplasm] (Sus scrofa)

phospho-p-CDK2 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_001277159.1, NP_001789.2, NP_439892.2

ZINC - World Drugs

CDK2_HUMAN

OpenTargets

ENSG00000123374

ZINC - FDA approved

CDK2_HUMAN

ZINC - Substances

CDK2_HUMAN

ZINC target

P24941

ZINC - Biogenic

CDK2_HUMAN

PRO

P24941

PDB

4I3Z, 3RAI, 4FKO, 2C4G, 1PXL, 4ERW, 3R1Y, 2R3G, 2JGZ, 1PXO, 1PF8, 1B38, 2VTR, 2UZB, 4BGH, 2VTO, 6ATH, 1H25, 3QQG, 2R3R, 3R8M, 5IEY, 1OL1, 1H28, 3RMF, 1H00, 3R8V, 2WMB, 2UUE, 2C5N, 4EZ3, 5ANI, 1FVV, 1URW, 4CFM, 4EOK, 2C6O, 5ANO, 2BTR, 3QZI, 3QTX, 6GUK, 3LFQ, 2R64, 3PY0, 4CFV, 1KE6, 6GUE, 2WPA, 5FP6, 3QZF, 3QTS, 3PXR, 4FKL, 1PXM, 3R1Q, 3RAL, 4FKQ, 1DI8, 1OKV, 1H26, 5MHQ, 2VTP, 3EID, 3R71, 3RPO, 2VTM, 5D1J, 3UNK, 1OL2, 1PXJ, 2R3P, 3DOG, 4FX3, 3R8U, 3IG7, 1H1S, 4EOJ, 3R9D, 5ANK, 6GUH, 2BTS, 3TNW, 2C6T, 1HCK, 2CJM, 4EOM, 2C6L, 3PXY, 4CFU, 3QTU, 3QZG, 5FP5, 3SW7, 4CFX, 3R1S, 3QTQ, 2CLX, 2HIC, 3BHV, 5NEV, 4FKP, 1G5S, 3PXF, 4RJ3, 1GIJ, 3ROY, 3EJ1, 3RJC, 4FKS, 1OKW, 3UNJ, 3R6X, 3LE6, 1PXK, 2R3Q, 2VTN, 3QHW, 4ACM, 1Y91, 3QXO, 2VTJ, 3FZ1, 1FVT, 1H1Q, 5JQ8, 3RPV, 2WIP, 2R3N, 3R7E, 2J9M, 3R8Z, 1H24, 2WMA, 4EZ7, 3QL8, 5OO0, 4EOL, 1HCL, 3EZV, 2C6M, 3R9N, 1F5Q, 1PW2, 4EOO, 3DDQ, 4BCM, 2C6I, 4CFW, 1FQ1, 3QTR, 1GIH, 3PXQ, 4GCJ, 1OIU, 3BHT, 1E9H, 1PXI, 4FKR, 5JQ5, 4FKU, 3QXP, 3R73, 5L2W, 3RPR, 2R3O, 1W8C, 3RK7, 2VTL, 1H1R, 2VTH, 5UQ2, 3QRT, 3NS9, 2R3L, 2B54, 3QX2, 1OIY, 3MY5, 3R7U, 3R9H, 5OO3, 2W17, 4KD1, 4BZD, 2BPM, 5LMK, 4EON, 2UZO, 1VYZ, 1OIR, 2WHB, 4II5, 4BCK, 2C6K, 2BKZ, 1GII, 4EOQ, 4BCO, 2IW8, 1H0W, 4EK4, 2C68, 1Y8Y, 3BHU, 2G9X, 4FKT, 3S0O, 1E1X, 5CYI, 4FKW, 3RK5, 3QHR, 3QRU, 1W98, 3RPY, 5UQ1, 2R3M, 2WIH, 2CCH, 2WXV, 2VTI, 3R7I, 2B55, 3RKB, 3QX4, 2W1H, 2R3J, 1GZ8, 1JSV, 2VU3, 5OO1, 3QWJ, 1H1P, 3EZR, 3R7Y, 4NJ3, 3R9O, 1OIT, 3QQK, 4EOP, 2UZL, 4EK3, 2V22, 4BCN, 2B52, 3DDP, 3TI1, 2IW9, 3S00, 1JVP, 2EXM, 4EOS, 4BCQ, 3F5X, 2C69, 1H08, 2W05, 5K4J, 4EK6, 1OI9, 2C5X, 5AND, 4FKV, 4D1Z, 3RK9, 2WEV, 2VV9, 1KE9, 2CCI, 1JST, 4FKG, 2VTA, 5UQ3, 1P2A, 2R3K, 1PXP, 1B39, 3RZB, 3R7V, 3RAH, 3QWK, 2I40, 2R3H, 2VTS, 1P5E, 3QQL, 1H0V, 2UZN, 3S2P, 2B53, 2UZD, 2BHE, 3QQH, 4EOR, 5IEX, 3R8L, 3RM7, 4EK5, 4BCP, 2IW6, 2W06, 1E1V, 5OSM, 1DM2, 1VYW, 1OIQ, 2C5Y, 2WFY, 4D1X, 2A4L, 6GUC, 5ANG, 3TIZ, 1YKR, 1KE7, 2A0C, 1H01, 3QTZ, 1BUH, 2C5O, 2XMY, 3LFS, 3EOC, 3S1H, 1JSU, 1FIN, 1R78, 1PYE, 4FKJ, 2R3I, 5IEV, 3R83, 3RAK, 2R3F, 3R28, 2VTT, 2VTQ, 2DS1, 5OSJ, 2UZE, 2BHH, 5IF1, 3QQJ, 2FVD, 1V1K, 1PXN, 3RM6, 3IGG, 3PY1, 1H07, 3QQF, 5A14, 1AQ1, 3R8P, 2DUV, 1H27, 1GY3, 1CKP, 4EK8, 3TIY, 1KE8, 6GUB, 2C5V, 3WBL, 1PKD, 5ANE, 1URC, 4EOI, 5ANJ, 2X1N, 1W0X, 2XNB, 4CFN, 2V0D, 3SQQ, 3QU0, 3ULI, 3RNI, 4LYN, 3PJ8, 1WCC, 1QMZ, 3QTW, 3PXZ, 3QZH, 3LFN, 4FKI, 6GUF, 3SW4, 1KE5, 1OGU

ZINC - Metabolites

CDK2_HUMAN

IntEnz

2.7.11.22

GeneCards

P24941

ZINC - Predictions - Purchasable

CDK2_HUMAN

HMDB Protein

HMDBP01383

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38936 CDKN1A	5	CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.973	27
UniProt:P20248 CCNA2	3	CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [nucleoplasm] (R-HSA-68905)	0.971	25
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.967	23
UniProt:P24864 CCNE1	3	CCNE1 [nucleoplasm] (R-HSA-68363) Unfolded CCNE1 [cytosol] (R-HSA-6813836) CCNE1 [cytosol] (R-HSA-157443)	0.957	20
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.938	20
UniProt:O96020 CCNE2	3	CCNE2 [cytosol] (R-HSA-157452) Unfolded CCNE2 [cytosol] (R-HSA-6813844) CCNE2 [nucleoplasm] (R-HSA-68367)	0.916	10
UniProt:Q16667 CDKN3			0.889	8
UniProt:Q13309 SKP2	2	SKP2 [nucleoplasm] (R-HSA-975554) SKP2 [cytosol] (R-HSA-975495)	0.788	7
UniProt:Q08999 RBL2	2	p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084) RBL2 [nucleoplasm] (R-HSA-389102)	0.758	5
UniProt:Q96PU4 UHRF2	1	UHRF2 [nucleoplasm] (R-HSA-976050)	0.729	5
UniProt:P14635 CCNB1	4	CCNB1 [cytosol] (R-HSA-157451) CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049)	0.725	6
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.713	3
UniProt:O95067 CCNB2	1	CCNB2 [cytosol] (R-HSA-68897)	0.702	3
UniProt:P51946 CCNH	1	CCNH [nucleoplasm] (R-HSA-69220)	0.693	3
UniProt:P24385 CCND1	4	p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) CCND1 [cytosol] (R-HSA-68328) CCND1 [nucleoplasm] (R-HSA-113832)	0.659	3
UniProt:P33552 CKS2			0.643	3
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.643	4
UniProt:Q9H211 CDT1	2	CDT1 [nucleoplasm] (R-HSA-68536) CDT1 [cytosol] (R-HSA-113788)	0.643	3
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.643	4
UniProt:Q09472 EP300	5	Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.641	5
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) IKBKG [cytosol] (R-HSA-168108) K63polyUb-NEMO [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397)	0.633	4
UniProt:Q8TD08 MK15			0.623	4
UniProt:P06400 RB1	3	p-RB1 [nucleoplasm] (R-HSA-188389) p-S795-RB1 [nucleoplasm] (R-HSA-69226) RB1 [nucleoplasm] (R-HSA-68642)	0.623	3
UniProt:Q9UQR0-1 SCML2			0.612	7
UniProt:O95835 LATS1	2	LATS1 [cytosol] (R-HSA-2028562) p-S909,T1097-LATS1 [cytosol] (R-HSA-2028551)	0.576	4
UniProt:P03129 VE7			0.564	2
UniProt:Q99523 SORT1	2	SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221) SORT1 [Golgi membrane] (R-HSA-434332)	0.564	2
UniProt:P51943 Ccna2	4	Ccna2 [nucleoplasm] (R-MMU-1362307) PolyUb-CCNA2 [nucleoplasm] (R-MMU-6783099) CCNA2 [cytosol] (R-MMU-157444) CCNA2 [nucleoplasm] (R-MMU-68905)	0.558	2
UniProt:P30274 CCNA2			0.544	2
UniProt:Q08619 IFI5B			0.544	2
UniProt:P49918 CDKN1C	3	CDKN1C [cytosol] (R-HSA-8941913) p-Y91-CDKN1C [cytosol] (R-HSA-8942606) CDKN1C [nucleoplasm] (R-HSA-8948130)	0.527	2
UniProt:Q92793 CREBBP	3	FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) SUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) CREBBP [nucleoplasm] (R-HSA-193545)	0.527	2
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.527	2
UniProt:Q14004 CDK13	3	CDK13 [ficolin-1-rich granule lumen] (R-HSA-6801374) CDK13 [extracellular region] (R-HSA-6806442) CDK13 [nucleoplasm] (R-HSA-6797014)	0.527	2
UniProt:Q9UQR0 SCML2			0.499	3
UniProt:Q8NA61-2 SPERT			0.488	2
UniProt:Q8N448 LNX2			0.488	2