Reactome | ORC2 [nucleoplasm]

ORC2 [nucleoplasm]

Stable Identifier

R-HSA-68405

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Orc2, Origin recognition complex subunit 2

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Locations in the PathwayBrowser for interactor UniProt:Q08050 FOXM1

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External Reference Information

External Reference

UniProt:Q13416 ORC2

Gene Names

ORC2, ORC2L

Chain

chain:1-577

Reference Genes

BioGPS Gene:4999 ORC2

COSMIC (genes):ORC2 ORC2

CTD Gene:4999 ORC2

dbSNP Gene:4999 ORC2

ENSEMBL:ENSG00000115942 ORC2

HGNC:8488 ORC2

KEGG:hsa:4999 ORC2

Monarch:4999 ORC2

NCBI Gene:4999 ORC2

OMIM:601182 ORC2

UCSC:Q13416 ORC2

Reference Transcript

Other Identifiers

11729210_at

11729211_a_at

11746739_a_at

16907173

204853_PM_at

204853_at

235423_PM_at

235423_at

2594566

2594567

2594570

2594571

2594572

2594573

2594574

2594575

2594576

2594577

2594578

2594581

2594582

2594583

2594584

2594585

2594587

2594588

2594589

2594590

2594591

2594594

2594597

2594599

2594601

2594604

2594605

2594607

2594610

2594611

2594612

2594613

2594614

2594615

2594616

39943_at

4999

76120_at

8058161

A_23_P39616

A_33_P3381410

GE59042

GE858128

GO:0000122

GO:0000781

GO:0000785

GO:0000792

GO:0000808

GO:0000939

GO:0003677

GO:0003688

GO:0005515

GO:0005634

GO:0005654

GO:0005664

GO:0005813

GO:0005815

GO:0006260

GO:0006270

GO:0006355

GO:0016020

GO:0043226

HMNXSV003015894

HMNXSV003026356

Hs.115572.0.A1_3p_at

ILMN_2061452

PH_hs_0022794

TC02002669.hg

TC02004778.hg

U27459_at

g5453829_3p_at

Participates

as an input of

ORC2 binds ORC3 (Homo sapiens)

as a component of

Inferred To

orcB [nucleoplasm] (Dictyostelium discoideum)

orc-2 [nucleoplasm] (Caenorhabditis elegans)

Orc2 [nucleoplasm] (Drosophila melanogaster)

Orc2 [nucleoplasm] (Mus musculus)

Orc2 [nucleoplasm] (Rattus norvegicus)

orc2 [nucleoplasm] (Danio rerio)

orc2 [nucleoplasm] (Schizosaccharomyces pombe)

orc2 [nucleoplasm] (Xenopus tropicalis)

ORC2 [nucleoplasm] (Bos taurus)

ORC2 [nucleoplasm] (Canis familiaris)

ORC2 [nucleoplasm] (Gallus gallus)

ORC2 [nucleoplasm] (Plasmodium falciparum)

ORC2 [nucleoplasm] (Saccharomyces cerevisiae)

ORC2 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

XP_006712618.1, NP_006181.1

OpenTargets

ENSG00000115942

ENSEMBL

ENSP00000234296, ENST00000234296

HPA

ENSG00000115942-ORC2

PRO

Q13416

Pharos - Targets

Q13416

GlyGen

Q13416

PDB

7JPO, 5UJ8, 7CTE, 7JPR, 7CTG, 5C8H, 7JPQ, 7CTF, 7JPS, 5UJM, 7JPP

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13415 ORC1	5	ORC1 [nucleoplasm] (R-HSA-68522) ORC1 [cytosol] (R-HSA-113840) p-S,T-ORC1 [nucleoplasm] (R-HSA-68943) PolyUb,p-S,T-ORC1 [nucleoplasm] (R-HSA-9032189) PolyUb,p-S,T-ORC1 [cytosol] (R-HSA-9032195)	0.888	14
UniProt:O43929 ORC4	1	ORC4 [nucleoplasm] (R-HSA-68519)	0.813	12
UniProt:O43913 ORC5	1	ORC5 [nucleoplasm] (R-HSA-68516)	0.81	15
UniProt:Q7L590 MCM10	1	MCM10 [nucleoplasm] (R-HSA-68403)	0.715	5
UniProt:Q9UBD5 ORC3	1	ORC3 [nucleoplasm] (R-HSA-68513)	0.702	28
UniProt:P03211 EBNA1			0.656	6
UniProt:Q9Y5N6 ORC6	4	ORC6 [nucleoplasm] (R-HSA-68539) ORC6 [cytosol] (R-HSA-9734663) p-T195-ORC6 [cytosol] (R-HSA-9734682) p-T195-ORC6 [nucleoplasm] (R-HSA-9734715)	0.643	3
UniProt:Q15554 TERF2	2	p-S365-TERF2 [nucleoplasm] (R-HSA-9686530) TERF2 [nucleoplasm] (R-HSA-174895)	0.602	3
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.59	2
UniProt:P57055 DSCR6			0.556	3
UniProt:Q9UI47-2 CTNNA3			0.556	3
UniProt:Q9NS91 RAD18	1	RAD18 [nucleoplasm] (R-HSA-5643731)	0.556	3
UniProt:Q9H668 STN1	1	STN1 [nucleoplasm] (R-HSA-9668821)	0.527	2
UniProt:P51114 FXR1	2	FXR1(2-784)-BRAF(381-766) fusion [cytosol] (R-HSA-6802326) FXR1(2-784)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802530)	0.527	2
UniProt:Q08050 FOXM1	3	p-T611,S730,S739-FOXM1 [nucleoplasm] (R-HSA-4088133) p-T611-FOXM1 [nucleoplasm] (R-HSA-4088026) FOXM1 [nucleoplasm] (R-HSA-4088019)	0.499	2
UniProt:P25205 MCM3	1	MCM3 [nucleoplasm] (R-HSA-68546)	0.499	2

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