Reactome | RFC2 [nucleoplasm]

RFC2 [nucleoplasm]

Stable Identifier

R-HSA-68433

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RFC40, Activator 1 40 kDa subunit, Replication factor C 40 kDa subunit, A1 40 kDa subunit, RF-C 40 kDa subunit

Locations in the PathwayBrowser for interactor UniProt:P06463 VE6

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Cell Cycle (Homo sapiens)

- Chromosome Maintenance (Homo sapiens)
  - Telomere Maintenance (Homo sapiens)
    - Extension of Telomeres (Homo sapiens)
      - Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
        
        Polymerase switching on the C-strand of the telomere (Homo sapiens)
        
        Formation of the CTF18-RFC(7s) complex (Homo sapiens)
        
        RFC2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35250 RFC2

Gene Names

RFC2

Chain

chain:1-354

Reference Genes

COSMIC (genes):RFC2 RFC2

dbSNP Gene:5982 RFC2

ENSEMBL:ENSG00000049541 RFC2

Participates

as an input of

Formation of the CTF18-RFC(7s) complex (Homo sapiens)

as a component of

Inferred To

Ghost homologue of RFC2 [nucleoplasm] (Danio rerio)

rfc-2 [nucleoplasm] (Caenorhabditis elegans)

rfc2 [nucleoplasm] (Xenopus tropicalis)

RFC2 [nucleoplasm] (Bos taurus)

RFC2 [nucleoplasm] (Canis familiaris)

RFC2 [nucleoplasm] (Dictyostelium discoideum)

RFC2 [nucleoplasm] (Drosophila melanogaster)

RFC2 [nucleoplasm] (Gallus gallus)

RFC2 [nucleoplasm] (Mus musculus)

RFC2 [nucleoplasm] (Plasmodium falciparum)

RFC2 [nucleoplasm] (Rattus norvegicus)

RFC2 [nucleoplasm] (Saccharomyces cerevisiae)

RFC2 [nucleoplasm] (Schizosaccharomyces pombe)

RFC2 [nucleoplasm] (Sus scrofa)

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35249 RFC4	1	RFC4 [nucleoplasm] (R-HSA-68429)	0.757	11
UniProt:O75943 RAD17	1	RAD17 [nucleoplasm] (R-HSA-3008665)	0.643	3
UniProt:P35251 RFC1	1	RFC1 [nucleoplasm] (R-HSA-68435)	0.641	4
UniProt:P40937 RFC5	1	RFC5 [nucleoplasm] (R-HSA-68427)	0.564	3
UniProt:P12004 PCNA	5	PCNA [nucleoplasm] (R-HSA-68439) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861)	0.527	2
UniProt:P10644 PRKAR1A	4	PRKAR1A [cytosol] (R-HSA-57836) PRKAR1A [ciliary base] (R-HSA-5610408) PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713471) PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713476)	0.524	7
UniProt:P06463 VE6			0.488	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2