Reactome | PCNA [nucleoplasm]

PCNA [nucleoplasm]

Stable Identifier

R-HSA-68439

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proliferating cell nuclear antigen, Cyclin

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Locations in the PathwayBrowser for interactor UniProt:P24941

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA replication proteins (Homo sapiens)
        
        SUMOylation of PCNA with SUMO1 (Homo sapiens)
        
        PCNA [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P12004 PCNA

Gene Names

PCNA

Chain

chain:1-261

Reference Genes

BioGPS Gene:5111 PCNA

COSMIC (genes):PCNA PCNA

CTD Gene:5111 PCNA

dbSNP Gene:5111 PCNA

ENSEMBL:ENSG00000132646 PCNA

HGNC:8729 PCNA

KEGG Gene (Homo sapiens):5111 PCNA

Monarch:5111 PCNA

NCBI Gene:5111 PCNA

OMIM:176740 PCNA

UCSC:P12004 PCNA

Reference Transcript

Other Identifiers

0000940088

0001050400

0001980181

11716103_a_at

16916958

1824_s_at

1884_s_at

201202_at

3896201

3896202

3896203

3896204

3896206

3896207

3896209

3896211

3896213

3896214

3896215

3896216

4006657

4006658

5111

8064844

A_23_P28886

A_33_P3258612

GE61312

GO:0000003

GO:0000083

GO:0000122

GO:0000228

GO:0000278

GO:0000307

GO:0000701

GO:0000723

GO:0000781

GO:0000785

GO:0003674

GO:0003677

GO:0003682

GO:0003684

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005652

GO:0005654

GO:0005657

GO:0005694

GO:0005813

GO:0005815

GO:0005856

GO:0006259

GO:0006260

GO:0006272

GO:0006275

GO:0006281

GO:0006283

GO:0006287

GO:0006296

GO:0006297

GO:0006298

GO:0006464

GO:0006950

GO:0006974

GO:0006977

GO:0006979

GO:0007049

GO:0007165

GO:0007507

GO:0008022

GO:0008134

GO:0008150

GO:0009058

GO:0016032

GO:0016567

GO:0016604

GO:0016798

GO:0019899

GO:0019985

GO:0030154

GO:0030234

GO:0030331

GO:0030337

GO:0030855

GO:0030894

GO:0030971

GO:0031297

GO:0032077

GO:0032139

GO:0032201

GO:0032355

GO:0032405

GO:0032991

GO:0033683

GO:0033993

GO:0034641

GO:0034644

GO:0035035

GO:0042276

GO:0042592

GO:0042769

GO:0042802

GO:0043226

GO:0043596

GO:0043626

GO:0044403

GO:0044849

GO:0044877

GO:0045739

GO:0045740

GO:0046686

GO:0048856

GO:0051276

GO:0070062

GO:0070182

GO:0070301

GO:0070557

GO:0070987

GO:0071466

GO:0071548

GO:0097421

GO:1900264

GO:1902065

GO:1902990

HMNXSV003000505

HMNXSV003026895

ILMN_1685682

ILMN_1694177

ILMN_1706958

J05614_at

M15796_at

PH_hs_0028994

TC20000592.hg

g4505640_3p_at

Participates

as an input of

SUMOylation of PCNA with SUMO1 (Homo sapiens)

as a component of

as an output of

PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)

Other forms of this molecule

SUMO1-K164,K254,K-PCNA [nucleoplasm]

K63polyUb-K164-PCNA [nucleoplasm]

ISG-K164,ISG-K168-PCNA [nucleoplasm]

MonoUb-K164-PCNA [nucleoplasm]

Inferred To

PCNA [nucleoplasm] (Bos taurus)

PCNA [nucleoplasm] (Canis familiaris)

PCNA [nucleoplasm] (Drosophila melanogaster)

PCNA [nucleoplasm] (Gallus gallus)

PCNA [nucleoplasm] (Plasmodium falciparum)

PCNA [nucleoplasm] (Sus scrofa)

pcna [nucleoplasm] (Danio rerio)

pcna [nucleoplasm] (Dictyostelium discoideum)

Pcna [nucleoplasm] (Mus musculus)

Pcna [nucleoplasm] (Rattus norvegicus)

POL30 [nucleoplasm] (Saccharomyces cerevisiae)

pcn-1 [nucleoplasm] (Caenorhabditis elegans)

pcn1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_002583.1, NP_872590.1

ZINC - World Drugs

PCNA_HUMAN

OpenTargets

ENSG00000132646

ZINC - FDA approved

PCNA_HUMAN

ZINC - Substances

PCNA_HUMAN

ZINC - Biogenic

PCNA_HUMAN

ZINC target

P12004

PRO

P12004

PDB

3P87, 6TNY, 5MOM, 3VKX, 4RJF, 5MAV, 6FCM, 6VVO, 4ZTD, 6TNZ, 4D2G, 5E0T, 1UL1, 3JA9, 3WGW, 1VYM, 1U7B, 6CBI, 6GWS, 6FCN, 5MLO, 5E0U, 6GIS, 3TBL, 1VYJ, 5E0V, 6S1M, 1W60, 1U76, 6EHT, 5YCO, 6QC0, 5MLW, 2ZVM, 6S1O, 6S1N, 1AXC, 6K3A, 5YD8, 2ZVL, 6HVO, 2ZVK, 6QCG, 5IY4

ZINC - Metabolites

PCNA_HUMAN

HPA

ENSG00000132646-PCNA

GeneCards

P12004

Ensembl

ENSP00000368458, ENSP00000368438, ENSG00000132646, ENST00000379160, ENST00000379143

ZINC - Predictions - Purchasable

PCNA_HUMAN

Orphanet

23426

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38936 CDKN1A	5	p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614) CDKN1A [cytosol] (R-HSA-182512) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585)	0.976	37
UniProt:P39748 FEN1	1	FEN1 [nucleoplasm] (R-HSA-54745)	0.956	19
UniProt:P12004 PCNA	5	K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) SUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.857	10
UniProt:Q15054 POLD3	1	POLD3 [nucleoplasm] (R-HSA-68445)	0.83	7
IntAct:EBI-4399559 UBIQ			0.811	7
UniProt:Q15004 PCLAF	2	MonoUb-K15,K24-KIAA0101 [nucleoplasm] (R-HSA-5655182) KIAA0101 [nucleoplasm] (R-HSA-5655178)	0.742	5
UniProt:Q13111 CAF1A			0.734	4
UniProt:P20585 MSH3	2	MSH3 [nucleoplasm] (R-HSA-5357519) MSH3 414TER [nucleoplasm] (R-HSA-5578664)	0.718	6
UniProt:P49005 POLD2	1	POLD2 [nucleoplasm] (R-HSA-68443)	0.678	3
UniProt:O95944 NCR2	1	NCR2 [plasma membrane] (R-HSA-197652)	0.672	7
UniProt:P28340 POLD1	2	POLD1 [nucleoplasm] (R-HSA-68449) POLD1 [cytosol] (R-HSA-2564763)	0.669	3
UniProt:A2RU14 TM218			0.666	4
UniProt:Q9Z111 GA45G			0.664	9
UniProt:P42771 CDKN2A	80	p16INK4A E88* [cytosol] (R-HSA-9632588) p16INK4A D84G [cytosol] (R-HSA-9632461) p16INK4A R87P [cytosol] (R-HSA-9632335) p16INK4A V126D [cytosol] (R-HSA-9631055) p16INK4A W110* [cytosol] (R-HSA-9632585) p16INK4A D84H [cytosol] (R-HSA-9632489) p16INK4A R80* [cytosol] (R-HSA-9632586) p16INK4A P114L [cytosol] (R-HSA-9630916) p16INK4A R58* [cytosol] (R-HSA-9632582) p16INK4A D84N [cytosol] (R-HSA-9632483) p16INK4A M53I [cytosol] (R-HSA-9630911) p16INK4A D84Y [cytosol] (R-HSA-9632478) p16INK4A G101W [cytosol] (R-HSA-9631257) p16INK4A P81L [cytosol] (R-HSA-9632280) p16INK4A A20P [cytosol] (R-HSA-9630805) p16INK4A D84V [cytosol] (R-HSA-9632465) p16INK4A P81T [cytosol] (R-HSA-9632275) p16INK4A P81H [cytosol] (R-HSA-9632293) p16INK4A D84A [cytosol] (R-HSA-9632486) p16INK4A P81R [cytosol] (R-HSA-9632294) p16INK4A E10* [cytosol] (R-HSA-9648382) p16INK4A S12* [cytosol] (R-HSA-9648383) p16INK4A P114T [cytosol] (R-HSA-9631034) p16INK4A P114S [cytosol] (R-HSA-9631027) p16INK4A G23fs3 [cytosol] (R-HSA-9648652) p16INK4A E61 [cytosol] (R-HSA-9648396) p16INK4A A20T [cytosol] (R-HSA-9630861) p16INK4A A36fs17 [cytosol] (R-HSA-9648653) p16INK4A E69 [cytosol] (R-HSA-9648397) p16INK4A W15fs1 [cytosol] (R-HSA-9648654) p16INK4A Y44 [cytosol] (R-HSA-9648398) p16INK4A T18fs15 [cytosol] (R-HSA-9648655) p16INK4A E26 [cytosol] (R-HSA-9648392) p16INK4A E33* [cytosol] (R-HSA-9648393) p16INK4A Q50* [cytosol] (R-HSA-9648394) p16INK4A E120* [cytosol] (R-HSA-9632587) p16INK4A S7fs8 [cytosol] (R-HSA-9648651) p16INK4A W15 [cytosol] (R-HSA-9648395) p16INK4A P75* [cytosol] (R-HSA-9648388) p16INK4A C72* [cytosol] (R-HSA-9648389) p16INK4A E119* [cytosol] (R-HSA-9648390) p16INK4A A20E [cytosol] (R-HSA-9630855) p16INK4A N39fs14 [cytosol] (R-HSA-9648647) p16INK4A P114R [cytosol] (R-HSA-9631046) p16INK4A P114H [cytosol] (R-HSA-9631043) p16INK4A E27 [cytosol] (R-HSA-9648387) p16INK4A P81S [cytosol] (R-HSA-9632287) p16INK4A G101V [cytosol] (R-HSA-9631263) p16INK4A Y44fs1 [cytosol] (R-HSA-9648664) p16INK4A V126I [cytosol] (R-HSA-9631130) p16INK4A L16fs9 [cytosol] (R-HSA-9648663) p16INK4A V126A [cytosol] (R-HSA-9631126) p16INK4A T18fs8 [cytosol] (R-HSA-9648656) p16INK4A V126F [cytosol] (R-HSA-9631120) p16INK4A L37fs16 [cytosol] (R-HSA-9648659) p16INK4A G35V [cytosol] (R-HSA-9631308) p16INK4A G23D [cytosol] (R-HSA-9630892) p16INK4A R24P [cytosol] (R-HSA-9630828) p16INK4A R80P [cytosol] (R-HSA-9632270) p16INK4A G35A [cytosol] (R-HSA-9631306) p16INK4A E88K [cytosol] (R-HSA-9632548) p16INK4A T77P [cytosol] (R-HSA-9632257) p16INK4A L97R [cytosol] (R-HSA-9632512) p16INK4A T18_A19dup [cytosol] (R-HSA-9632192) p16INK4A G67_N71del [cytosol] (R-HSA-9632252) p16INK4A A60R [cytosol] (R-HSA-9632216) p16INK4A D74Y [cytosol] (R-HSA-9632088) p16INK4A A60V [cytosol] (R-HSA-9632212) p16INK4A R112_L113insR [cytosol] (R-HSA-9632566) p16INK4A R99P [cytosol] (R-HSA-9632531) p16INK4A A60S [cytosol] (R-HSA-9632206) p16INK4A L97P [cytosol] (R-HSA-9632523) p16INK4A G23S [cytosol] (R-HSA-9631163) p16INK4A A60E [cytosol] (R-HSA-9632202) p16INK4A G23V [cytosol] (R-HSA-9631157) p16INK4A G35R [cytosol] (R-HSA-9631316) p16INK4A T77S [cytosol] (R-HSA-9632256) p16INK4A [cytosol] (R-HSA-182578) p16INK4A G35E [cytosol] (R-HSA-9631314) p16INK4A G35W [cytosol] (R-HSA-9631328)	0.61	8
UniProt:Q5FWF4 ZRAB3			0.599	8
UniProt:Q9H063 MAF1	3	MAF1 [cytosol] (R-HSA-8944460) p-S60,S68,S75-MAF1 [cytosol] (R-HSA-8944455) MAF1 [nucleoplasm] (R-HSA-8944422)	0.581	4
UniProt:P30041 PRDX6	3	PRDX6 [extracellular region] (R-HSA-6806198) PRDX6 [cytosol] (R-HSA-3343670) PRDX6 [azurophil granule lumen] (R-HSA-6798744)	0.573	2
UniProt:P61769 B2M	11	B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [early endosome membrane] (R-HSA-182298) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [plasma membrane] (R-HSA-167743)	0.573	3
UniProt:P07355 ANXA2	4	ANXA2 [external side of plasma membrane] (R-HSA-5336164) ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [extracellular region] (R-HSA-6806242) ANXA2 [azurophil granule lumen] (R-HSA-6798766)	0.573	2
UniProt:P00558 PGK1	1	PGK1 [cytosol] (R-HSA-70483)	0.573	2
UniProt:P68104 EEF1A1	7	Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.573	2
UniProt:P04075 ALDOA	6	ALDOA [tertiary granule lumen] (R-HSA-6801485) ALDOA [platelet alpha granule lumen] (R-HSA-349738) ALDOA [ficolin-1-rich granule lumen] (R-HSA-6801521) ALDOA [extracellular region] (R-HSA-349735) ALDOA [secretory granule lumen] (R-HSA-6801469) ALDOA [cytosol] (R-HSA-71492)	0.571	3
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.571	3
UniProt:P06733 ENO1	1	ENO1 [cytosol] (R-HSA-71437)	0.571	3
UniProt:Q14527 HLTF	1	HLTF [nucleoplasm] (R-HSA-8855007)	0.564	2
UniProt:P61970 NTF2			0.556	3
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:Q8IWU4 SLC30A8	1	SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:P03129 VE7			0.547	2
UniProt:A8CG34 POM121C	1	POM121C [nuclear envelope] (R-HSA-6805165)	0.547	2
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.547	2
UniProt:P18669 PGAM1	4	PGAM1 [extracellular region] (R-HSA-6806482) PGAM1 [ficolin-1-rich granule lumen] (R-HSA-6803309) PGAM1 [secretory granule lumen] (R-HSA-6803293) PGAM1 [cytosol] (R-HSA-71442)	0.544	2
UniProt:P60174 TPI1	1	TPI1 [cytosol] (R-HSA-70451)	0.544	2
UniProt:Q9H160 ING2	2	ING2 [nucleoplasm] (R-HSA-3215167) SUMO1-K195-ING2 [nucleoplasm] (R-HSA-4086075)	0.544	3
UniProt:P03950 ANG	2	ANG [extracellular region] (R-HSA-5692435) ANG [cytosol] (R-HSA-9708345)	0.537	4
UniProt:P24941 CDK2	5	CDK2 [cytosol] (R-HSA-157440) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q9HCU8 POLD4	1	POLD4 [nucleoplasm] (R-HSA-68447)	0.524	4
UniProt:Q86TU7 SETD3	1	SETD3 [nucleoplasm] (R-HSA-5688411)	0.508	3
UniProt:Q1K9H5 Q1K9H5			0.508	2
UniProt:B4URF7 B4URF7			0.508	2
UniProt:Q9UBF6 RNF7	1	RNF7 (RBX2) [cytosol] (R-HSA-8863132)	0.508	3
UniProt:Q8TE30 Q8TE30			0.499	6
UniProt:Q9H211 CDT1	2	CDT1 [nucleoplasm] (R-HSA-68536) CDT1 [cytosol] (R-HSA-113788)	0.499	2
UniProt:P57081 WDR4	1	WDR4 [nucleoplasm] (R-HSA-6782341)	0.462	3

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