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What is Reactome ?
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POLE2 [nucleoplasm]
Stable Identifier
R-HSA-68482
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA polymerase epsilon subunit B , DNA polymerase II subunit B
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA replication initiation (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
PCNA-Dependent Long Patch Base Excision Repair (Homo sapiens)
FEN1 bound to PCNA and APEX1 cleaves flap ssDNA (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Termination of translesion DNA synthesis (Homo sapiens)
POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
D-loop extension by DNA polymerases (Homo sapiens)
PCNA:POLD,POLE,POLH,POLK:RPA:RFC [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Dual Incision in GG-NER (Homo sapiens)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA replication initiation (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P56282 POLE2
Gene Names
POLE2, DPE2
Chain
chain:1-527
Reference Genes
BioGPS Gene:5427 POLE2
COSMIC (genes):POLE2 POLE2
CTD Gene:5427 POLE2
dbSNP Gene:5427 POLE2
ENSEMBL:ENSG00000100479 POLE2
HGNC:9178 POLE2
KEGG:hsa:5427 POLE2
Monarch:5427 POLE2
NCBI Gene:5427 POLE2
OMIM:602670 POLE2
UCSC:P56282 POLE2
Reference Transcript
RefSeq:NM_001197330.2 POLE2
RefSeq:NM_001197331.3 POLE2
RefSeq:NM_001348384.1 POLE2
RefSeq:NM_002692.3 POLE2
Other Identifiers
11744519_a_at
16792519
205909_PM_at
205909_at
3563396
3563399
3563400
3563401
3563402
3563403
3563404
3563405
3563406
3563407
3563408
3563409
3563410
3563411
3563412
3563413
3563414
3563415
3563417
3563418
3563422
3563423
3563424
3563425
3563426
3563427
3563434
3563435
3563436
3563437
3563438
3563446
41085_at
5427
7978846
A_23_P163099
GE81181
GO:0003677
GO:0003824
GO:0003887
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006259
GO:0006260
GO:0006261
GO:0006281
GO:0008622
GO:0016604
GO:0016740
GO:0031981
GO:0042276
GO:0140097
HMNXSV003032006
ILMN_1774336
PH_hs_0005513
TC14001105.hg
g4505934_3p_at
Participates
as a component of
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
Inferred To
pole-2 [nucleoplasm]
(Caenorhabditis elegans)
PolE2 [nucleoplasm]
(Drosophila melanogaster)
Pole2 [nucleoplasm]
(Mus musculus)
Pole2 [nucleoplasm]
(Rattus norvegicus)
dpb2 [nucleoplasm]
(Schizosaccharomyces pombe)
DPB2 [nucleoplasm]
(Saccharomyces cerevisiae)
POLE2 [nucleoplasm]
(Bos taurus)
POLE2 [nucleoplasm]
(Canis familiaris)
POLE2 [nucleoplasm]
(Gallus gallus)
POLE2 [nucleoplasm]
(Plasmodium falciparum)
POLE2 [nucleoplasm]
(Sus scrofa)
pole2 [nucleoplasm]
(Danio rerio)
pole2 [nucleoplasm]
(Dictyostelium discoideum)
pole2 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001335313.1
,
NP_001184259.1
,
NP_002683.2
,
NP_001184260.1
ENSEMBL
ENSP00000451621
,
ENST00000216367
,
ENST00000539565
,
ENSG00000100479
,
ENST00000554396
,
ENSP00000216367
,
ENSP00000446313
OpenTargets
ENSG00000100479
GeneCards
POLE2
HPA
ENSG00000100479-POLE2
PRO
P56282
Pharos - Targets
P56282
HMDB Protein
HMDBP00970
PDB
2V6Z
,
5VBN
,
7PFO
,
7PLO
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.781
7
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.556
3
UniProt:P52594 AGFG1
1
AGFG1 [cytosol]
(R-HSA-8863714)
0.556
3
UniProt:Q9Y337 KLK5
4
KLK5 [extracellular region]
(R-HSA-8849629)
proKLK5 [extracellular region]
(R-HSA-8849836)
KLK5 propeptide [extracellular region]
(R-HSA-8849839)
KLK5 [cytosol]
(R-HSA-8934778)
0.527
2
UniProt:P56559 ARL4C
1
ARL4C [plasma membrane]
(R-HSA-9618406)
0.527
2
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