Reactome | ORC5 [nucleoplasm]

ORC5 [nucleoplasm]

Stable Identifier

R-HSA-68516

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Orc5, Origin recognition complex subunit 5

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Locations in the PathwayBrowser for interactor UniProt:O60939 SCN2B

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External Reference Information

External Reference

UniProt:O43913 ORC5

Gene Names

ORC5, ORC5L

Chain

chain:1-435

Reference Genes

BioGPS Gene:5001 ORC5

COSMIC (genes):ORC5 ORC5

CTD Gene:5001 ORC5

dbSNP Gene:5001 ORC5

ENSEMBL:ENSG00000164815 ORC5

HGNC:8491 ORC5

KEGG:hsa:5001 ORC5

Monarch:5001 ORC5

NCBI Gene:5001 ORC5

OMIM:602331 ORC5

UCSC:O43913 ORC5

Reference Transcript

Other Identifiers

11727070_a_at

11737708_a_at

11737709_x_at

17061374

204957_PM_at

204957_at

211212_PM_s_at

211212_s_at

211213_PM_at

211213_at

3065964

3065965

3065966

3065967

3065968

3065969

3065970

3065971

3065972

3065973

3065974

3065979

3065980

3065984

3065985

3065986

3065987

3065988

3065989

3065990

3065991

3065993

3065994

3065995

3065996

38155_at

5001

8142019

A_23_P31414

A_24_P394698

GE59571

GO:0000166

GO:0000781

GO:0000785

GO:0000808

GO:0003674

GO:0003677

GO:0003688

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005664

GO:0005694

GO:0005829

GO:0006260

GO:0006270

GO:0006275

GO:0043226

HMNXSV003025755

HMNXSV003035295

HMNXSV003047353

ILMN_1686987

ILMN_1688094

ILMN_1705093

PH_hs_0009207

TC07001724.hg

g3766213_3p_at

g4505524_3p_at

Participates

as a component of

as an input of

ORC5 binds ORC2:ORC3 (Homo sapiens)

Inferred To

orcE [nucleoplasm] (Dictyostelium discoideum)

ORC5 [nucleoplasm] (Bos taurus)

ORC5 [nucleoplasm] (Canis familiaris)

ORC5 [nucleoplasm] (Drosophila melanogaster)

ORC5 [nucleoplasm] (Gallus gallus)

ORC5 [nucleoplasm] (Mus musculus)

ORC5 [nucleoplasm] (Plasmodium falciparum)

ORC5 [nucleoplasm] (Saccharomyces cerevisiae)

ORC5 [nucleoplasm] (Schizosaccharomyces pombe)

ORC5 [nucleoplasm] (Sus scrofa)

orc-5 [nucleoplasm] (Caenorhabditis elegans)

orc5 [nucleoplasm] (Danio rerio)

orc5 [nucleoplasm] (Xenopus tropicalis)

Orc5 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_859531.1, NP_002544.1

OpenTargets

ENSG00000164815

ENSEMBL

ENSP00000297431, ENSP00000395747, ENST00000447452, ENSG00000164815, ENST00000297431

HPA

ENSG00000164815-ORC5

GeneCards

ORC5

PRO

O43913

Pharos - Targets

O43913

GlyGen

O43913

PDB

5UJM, 5UJ7, 7JPQ, 7JPS, 7JPP, 8S0E, 8S0C, 7JPO, 8S0F, 8S0D, 7CTG, 7CTE, 7CTF, 7JPR

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13415 ORC1	5	ORC1 [nucleoplasm] (R-HSA-68522) ORC1 [cytosol] (R-HSA-113840) p-S,T-ORC1 [nucleoplasm] (R-HSA-68943) PolyUb,p-S,T-ORC1 [nucleoplasm] (R-HSA-9032189) PolyUb,p-S,T-ORC1 [cytosol] (R-HSA-9032195)	0.868	11
UniProt:Q13416 ORC2	1	ORC2 [nucleoplasm] (R-HSA-68405)	0.81	15
UniProt:Q9UBD5 ORC3	1	ORC3 [nucleoplasm] (R-HSA-68513)	0.59	15
UniProt:O43929 ORC4	1	ORC4 [nucleoplasm] (R-HSA-68519)	0.59	2
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [specific granule membrane] (R-HSA-6799516) C3AR1 [azurophil granule membrane] (R-HSA-6799517)	0.527	2
UniProt:Q8WVE6 TM171			0.527	2
UniProt:A2RU67 F234B			0.527	3
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.527	2
UniProt:O60939 SCN2B	1	SCN2B [plasma membrane] (R-HSA-197905)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:P32970 CD70	1	CD70 [plasma membrane] (R-HSA-5667139)	0.527	2
UniProt:O95274 LYPD3	2	cleaved GPI-LYPD3 [extracellular region] (R-HSA-8941013) GPI-LYPD3 [plasma membrane] (R-HSA-8940752)	0.527	2
UniProt:P41587 VIPR2	1	VIPR2 [plasma membrane] (R-HSA-420227)	0.527	2
UniProt:P16444 DPEP1	1	DPEP1 [plasma membrane] (R-HSA-2142820)	0.527	2
UniProt:Q15233 NONO			0.519	2

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