Reactome | CDC6 [nucleoplasm]

CDC6 [nucleoplasm]

Stable Identifier

R-HSA-68542

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G2/M Checkpoints (Homo sapiens)
    - Activation of ATR in response to replication stress (Homo sapiens)
      - Activation of claspin (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
      - Loading of claspin onto DNA during replication origin firing (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G0 and Early G1 (Homo sapiens)
      - Transcription of E2F targets under negative control by DREAM complex (Homo sapiens)
        
        CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Activation of the pre-replicative complex (Homo sapiens)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        DNA polymerase alpha:primase binds at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon binds at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
        
        MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
      - G1/S-Specific Transcription (Homo sapiens)
        
        CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Synthesis of DNA (Homo sapiens)
      - Switching of origins to a post-replicative state (Homo sapiens)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
        
        Cdc6 protein is phosphorylated by CDK (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        Orc1 removal from chromatin (Homo sapiens)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99741 CDC6

Gene Names

CDC6, CDC18L

Chain

chain:1-560

Reference Genes

BioGPS Gene:990 CDC6

COSMIC (genes):CDC6 CDC6

CTD Gene:990 CDC6

dbSNP Gene:990 CDC6

ENSEMBL:ENSG00000094804 CDC6

ENSEMBL_homo_sapiens_GENE:ENSG00000094804.12 CDC6

HGNC:1744 CDC6

KEGG Gene (Homo sapiens):990 CDC6

Monarch:990 CDC6

NCBI Gene:990 CDC6

OMIM:602627 CDC6

UCSC:Q99741 CDC6

Reference Transcript

RefSeq:NM_001254.3 CDC6

Other Identifiers

11743064_at

11743065_at

1536_at

16834056

203967_PM_at

203967_at

203968_PM_s_at

203968_s_at

36839_at

3720897

3720900

3720901

3720902

3720903

3720904

3720905

3720906

3720907

3720910

3720913

3720914

3720916

3720917

3720918

3720920

8007071

990

A_14_P127674

A_23_P49972

A_33_P3218450

GE59420

GO:0000076

GO:0000079

GO:0000166

GO:0000278

GO:0000910

GO:0000922

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0006260

GO:0006270

GO:0007049

GO:0007059

GO:0007089

GO:0008156

GO:0008285

GO:0016787

GO:0016887

GO:0019900

GO:0023052

GO:0030071

GO:0032467

GO:0033314

GO:0036211

GO:0043226

GO:0045171

GO:0048146

GO:0051233

GO:0051301

GO:0051984

GO:0072686

GO:0140657

GO:1904117

GO:1904385

HMNXSV003051890

ILMN_1785914

PH_hs_0033144

TC17000495.hg

U77949_at

g4502702_3p_a_at

p7354

Participates

as an input of

as a component of

as an output of

CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)

Other forms of this molecule

CDC6 [cytosol]

p-CDC6 [cytosol]

p-CDC6 [nucleoplasm]

Inferred To

Cdc6 [nucleoplasm] (Drosophila melanogaster)

Cdc6 [nucleoplasm] (Rattus norvegicus)

cdc6 [nucleoplasm] (Danio rerio)

cdc6 [nucleoplasm] (Xenopus tropicalis)

cdc-6 [nucleoplasm] (Caenorhabditis elegans)

CDC6 [nucleoplasm] (Bos taurus)

CDC6 [nucleoplasm] (Canis familiaris)

CDC6 [nucleoplasm] (Dictyostelium discoideum)

CDC6 [nucleoplasm] (Gallus gallus)

CDC6 [nucleoplasm] (Mus musculus)

CDC6 [nucleoplasm] (Plasmodium falciparum)

CDC6 [nucleoplasm] (Saccharomyces cerevisiae)

CDC6 [nucleoplasm] (Schizosaccharomyces pombe)

CDC6 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001245.1

OpenTargets

ENSG00000094804

HPA

ENSG00000094804-CDC6

GeneCards

Q99741

Ensembl

ENSP00000497345, ENSG00000094804, ENSP00000209728, ENST00000649662, ENST00000209728

PRO

Q99741

Pharos - Targets

Q99741

Orphanet

19837

PDB

4I5L, 2CCH, 4I5N, 2CCI

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.632	6
UniProt:Q9H211 CDT1	1	CDT1 [nucleoplasm] (R-HSA-68536)	0.609	3
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.571	2
UniProt:O60637 TSN3			0.527	2
UniProt:Q86XD5 FAM131B	2	FAM131B(1-18)-BRAF(381-766) fusion [cytosol] (R-HSA-6802323) FAM131B(1-18)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802527)	0.527	2
UniProt:Q9Y5F2 PCDBB			0.527	2
UniProt:Q9H8J5 MANS1			0.527	2
UniProt:O14498 ISLR	2	ISLR [extracellular region] (R-HSA-8848919) ISLR [platelet alpha granule lumen] (R-HSA-8848912)	0.527	2
UniProt:Q9UHF4 IL20RA	1	IL20RA [plasma membrane] (R-HSA-448713)	0.527	2
UniProt:P28908 TNFRSF8	1	TNFRSF8 [plasma membrane] (R-HSA-5668758)	0.527	2
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.527	2
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.524	2
UniProt:O95801 TTC4			0.482	2

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