Reactome | MCM4 [nucleoplasm]

MCM4 [nucleoplasm]

Stable Identifier

R-HSA-68549

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mcm4, DNA replication licensing factor MCM4, CDC21 homolog, P1-CDC21

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G2/M Checkpoints (Homo sapiens)
    - Activation of ATR in response to replication stress (Homo sapiens)
      - Activation of claspin (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
      - Loading of claspin onto DNA during replication origin firing (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Activation of the pre-replicative complex (Homo sapiens)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        DNA polymerase alpha:primase binds at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon binds at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
        
        MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        Mcm2-7 is phosphorylated by DDK (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        p-MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Synthesis of DNA (Homo sapiens)
      - DNA strand elongation (Homo sapiens)
        
        Unwinding of DNA (Homo sapiens)
        
        MCM2-7 mediated fork unwinding (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        Multiple proteins are localized at replication fork (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        Unwinding complex at replication fork [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
      - Switching of origins to a post-replicative state (Homo sapiens)
        
        Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        Mcm4,6,7 complex [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        Orc1 removal from chromatin (Homo sapiens)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P33991 MCM4

Gene Names

MCM4, CDC21

Chain

initiator methionine:1, chain:2-863

Reference Genes

BioGPS Gene:4173 MCM4

COSMIC (genes):MCM4 MCM4

CTD Gene:4173 MCM4

dbSNP Gene:4173 MCM4

ENSEMBL:ENSG00000104738 MCM4

HGNC:6947 MCM4

KEGG Gene (Homo sapiens):4173 MCM4

Monarch:4173 MCM4

NCBI Gene:4173 MCM4

OMIM:602638 MCM4

UCSC:P33991 MCM4

Reference Transcript

Other Identifiers

0001580601

0007100167

11736670_a_at

11743692_a_at

11743693_a_at

11759509_s_at

11759510_x_at

17068782

17068812

212141_at

212142_at

222036_s_at

222037_at

242479_s_at

3097154

3097155

3097156

3097157

3097160

3097161

3097163

3097164

3097165

3097166

3097167

3097168

3097170

3097171

3097172

3097173

3097180

3097181

3097183

3097184

3097185

3097186

3097190

3097191

3097192

3097194

3097195

3097196

3097197

3097198

3097199

3097200

3097201

3097202

3097203

3097205

4173

52597_at

63855_r_at

8146357

8146377

981_at

A_14_P118280

A_14_P118623

A_23_P370989

GO:0000082

GO:0000166

GO:0000228

GO:0000278

GO:0000727

GO:0000784

GO:0003674

GO:0003677

GO:0003678

GO:0003688

GO:0003697

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006259

GO:0006260

GO:0006267

GO:0006268

GO:0006270

GO:0006271

GO:0006950

GO:0007049

GO:0008150

GO:0009058

GO:0016020

GO:0016787

GO:0016887

GO:0022607

GO:0032991

GO:0034641

GO:0042555

GO:0043167

GO:0043226

GO:0051276

GO:0065003

GO:1902975

Hs.154443.0.S1_3p_at

Hs.154443.0.S2_3p_at

Hs.154443.1.S1_3p_a_at

Hs.154443.1.S1_3p_x_at

Hs.296277.0.S1_3p_s_at

ILMN_1737205

ILMN_1771558

ILMN_2412860

PH_hs_0026403

TC08000346.hg

TC08000347.hg

X74794_at

Participant Of

hasComponent

Inferred To

mcm4 [nucleoplasm] (Danio rerio)

mcm4 [nucleoplasm] (Schizosaccharomyces pombe)

mcm4 [nucleoplasm] (Xenopus tropicalis)

Mcm4 [nucleoplasm] (Mus musculus)

Mcm4 [nucleoplasm] (Rattus norvegicus)

mcm-4 [nucleoplasm] (Caenorhabditis elegans)

dpa [nucleoplasm] (Drosophila melanogaster)

MCM4 [nucleoplasm] (Bos taurus)

MCM4 [nucleoplasm] (Canis familiaris)

MCM4 [nucleoplasm] (Dictyostelium discoideum)

MCM4 [nucleoplasm] (Gallus gallus)

MCM4 [nucleoplasm] (Plasmodium falciparum)

MCM4 [nucleoplasm] (Saccharomyces cerevisiae)

MCM4 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_877423.1, NP_005905.2

OpenTargets

ENSG00000104738

HPA

ENSG00000104738-MCM4

GeneCards

P33991

Ensembl

ENSG00000104738, ENST00000649973, ENST00000262105, ENSP00000262105, ENSP00000496964

PRO

P33991

Orphanet

20911

HMDB Protein

HMDBP11818

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.78	7
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.697	6
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.602	3
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.564	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P62805 H4C1	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.527	3
UniProt:P53350 PLK1	4	p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [cytosol] (R-HSA-164603)	0.508	2

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