Reactome | MCM7 [nucleoplasm]

MCM7 [nucleoplasm]

Stable Identifier

R-HSA-68555

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mcm7, DNA replication licensing factor MCM7, CDC47 homolog, P1.1-MCM3

Locations in the PathwayBrowser for interactor UniProt:P06463 VE6

Expand all

External Reference Information

External Reference

UniProt:P33993 MCM7

Gene Names

MCM7, CDC47, MCM2

Chain

initiator methionine:, chain:2-719

Reference Genes

BioGPS Gene:4176 MCM7

COSMIC (genes):MCM7 MCM7

CTD Gene:4176 MCM7

dbSNP Gene:4176 MCM7

ENSEMBL:ENSG00000166508 MCM7

ENSEMBL_homo_sapiens_GENE:ENSG00000166508.19 MCM7

HGNC:6950 MCM7

KEGG Gene (Homo sapiens):4176 MCM7

Monarch:4176 MCM7

NCBI Gene:4176 MCM7

OMIM:600592 MCM7

UCSC:P33993 MCM7

Reference Transcript

Other Identifiers

11729603_a_at

11752905_a_at

11753558_x_at

11755469_x_at

17060412

208795_PM_s_at

208795_s_at

210983_PM_s_at

210983_s_at

3063686

3063687

3063688

3063689

3063690

3063696

3063697

3063699

3063700

3063701

3063702

3063703

3063704

3063705

3063708

3063709

3063710

3063711

3063712

3063714

3063715

3063717

3063718

3063719

3063721

3063725

3063726

4176

8141395

947_at

A_23_P93690

A_33_P3258223

D55716_at

GE57265

GO:0000166

GO:0000228

GO:0000727

GO:0000781

GO:0000785

GO:0003677

GO:0003678

GO:0003697

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006259

GO:0006260

GO:0006268

GO:0006270

GO:0006271

GO:0006281

GO:0006310

GO:0006974

GO:0007049

GO:0008283

GO:0016020

GO:0016787

GO:0016887

GO:0017116

GO:0030174

GO:0032508

GO:0042325

GO:0042555

GO:0043226

GO:0043229

GO:0071162

GO:0071466

GO:0140097

GO:0140657

HMNXSV003041394

ILMN_1663195

ILMN_1704702

PH_hs_0020775

TC07001654.hg

g1255616_3p_a_at

g12751125_3p_a_at

Participates

as an input of

MCM4, MCM6 and MCM7 form a heterotrimer (Homo sapiens)

as a component of

MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)

Inferred To

mcm7 [nucleoplasm] (Danio rerio)

mcm-7 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of MCM7 [nucleoplasm] (Gallus gallus)

MCM7 [nucleoplasm] (Bos taurus)

MCM7 [nucleoplasm] (Canis familiaris)

MCM7 [nucleoplasm] (Dictyostelium discoideum)

MCM7 [nucleoplasm] (Drosophila melanogaster)

MCM7 [nucleoplasm] (Mus musculus)

MCM7 [nucleoplasm] (Plasmodium falciparum)

MCM7 [nucleoplasm] (Rattus norvegicus)

MCM7 [nucleoplasm] (Saccharomyces cerevisiae)

MCM7 [nucleoplasm] (Schizosaccharomyces pombe)

MCM7 [nucleoplasm] (Sus scrofa)

MCM7 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001265524.1, NP_877577.1, NP_005907.3

OpenTargets

ENSG00000166508

GeneCards

P33993

HPA

ENSG00000166508-MCM7

Ensembl

ENST00000303887, ENSP00000307288, ENSG00000166508, ENSP00000344006, ENST00000343023

PRO

P33993

Pharos - Targets

P33993

HMDB Protein

HMDBP10786

PDB

6XTX, 8B9D, 7PFO, 7W1Y, 7PLO, 6XTY, 7W68

Interactors (55)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.931	24
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.924	15
UniProt:Q9BTE3 MCMBP			0.9	21
UniProt:Q14566 MCM6	1	MCM6 [nucleoplasm] (R-HSA-68553)	0.823	7
UniProt:P25205 MCM3	1	MCM3 [nucleoplasm] (R-HSA-68546)	0.758	13
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.731	7
UniProt:Q9BTE3-2 MCMBP			0.718	6
UniProt:P33992 MCM5	1	MCM5 [nucleoplasm] (R-HSA-68551)	0.688	10
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.669	3
UniProt:P03126 VE6			0.667	3
UniProt:Q96MA6 AK8	1	AK8 [cytosol] (R-HSA-6788788)	0.666	4
UniProt:Q14683 SMC1A	4	SMC1A [cytosol] (R-HSA-2484798) SMC1A [chromosome] (R-HSA-1638774) SMC1A [chromosome, centromeric region] (R-HSA-2466015) SMC1A [nucleoplasm] (R-HSA-64561)	0.645	8
UniProt:Q9UL03 INTS6	1	INTS6 [nucleoplasm] (R-HSA-6807440)	0.625	10
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	20
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.609	2
UniProt:P04019 VE6			0.592	2
UniProt:P07948-1 LYN			0.591	5
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.564	2
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q68D86 C102B			0.556	3
UniProt:Q9UMX0-2 UBQLN1			0.556	3
UniProt:Q8TD10 MIPO1			0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q9NS73-5 MBIP			0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q02086 SP2			0.556	3
IntAct:EBI-10206361 116328			0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.527	3
UniProt:Q9BRT9 GINS4	1	GINS4 [nucleoplasm] (R-HSA-176963)	0.527	3
UniProt:Q9Y248 GINS2	1	GINS2 [nucleoplasm] (R-HSA-176975)	0.527	3
UniProt:Q96QK1 VPS35	1	VPS35 [cytosol] (R-HSA-3247740)	0.527	3
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.527	3
UniProt:P06462 VE6			0.527	2
UniProt:Q14691 GINS1	1	GINS1 [nucleoplasm] (R-HSA-176955)	0.527	3
UniProt:P06463 VE6			0.527	2
UniProt:O75436 VPS26A	1	VPS26A [cytosol] (R-HSA-3247739)	0.527	3
UniProt:Q9BVW5 TIPIN	1	TIPIN [nucleoplasm] (R-HSA-5684983)	0.527	2
UniProt:Q96A08 H2BC1	9	HIST1H2BA [nucleoplasm] (R-HSA-181916) Ub-122-HIST1H2BA [nucleoplasm] (R-HSA-3364020) AcK22-HIST1H2BA [nucleoplasm] (R-HSA-4568647) AcK17-HIST1H2BA [nucleoplasm] (R-HSA-4568631) AcK14-HIST1H2BA [nucleoplasm] (R-HSA-4568615) AcK7-HIST1H2BA [nucleoplasm] (R-HSA-4568624) HIST1H2BA [extracellular region] (R-HSA-977582) AcK-HIST1H2BA [nucleoplasm] (R-HSA-4549263) Ub-HIST1H2BA [nucleoplasm] (R-HSA-6782561)	0.527	4
UniProt:Q9Y468 L3MBTL1	1	L3MBTL1 [nucleoplasm] (R-HSA-3222110)	0.527	2
UniProt:Q9BRX5 GINS3	1	GINS3 [nucleoplasm] (R-HSA-5688046)	0.527	3
UniProt:Q9NVP2 ASF1B			0.527	3
UniProt:O15078 CEP290	3	CEP290 [extracellular region] (R-HSA-6806291) CEP290 [specific granule lumen] (R-HSA-6799524) CEP290 [cytosol] (R-HSA-380275)	0.527	2
UniProt:P49918 CDKN1C	3	p-Y91-CDKN1C [cytosol] (R-HSA-8942606) CDKN1C [cytosol] (R-HSA-8941913) CDKN1C [nucleoplasm] (R-HSA-8948130)	0.527	2
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563)	0.527	2
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.527	3
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.527	3
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.524	4
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [cytosol] (R-HSA-354251)	0.499	4
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P03366 POL			0.462	2
UniProt:O75164 KDM4A	2	K48PolyUb-KDM4A [nucleoplasm] (R-HSA-5683049) KDM4A [nucleoplasm] (R-HSA-351646)	0.462	3

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