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CDC45 [nucleoplasm]
Stable Identifier
R-HSA-68563
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cdc45, CDC45-related protein, PORC-PI-1
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Activation of claspin (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
Loading of claspin onto DNA during replication origin firing (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1-G1/S phases (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
CDC45 gene expression is stimulated by E2F1 (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Unwinding of DNA (Homo sapiens)
Multiple proteins are localized at replication fork (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
Unwinding complex at replication fork [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Unwinding of DNA (Homo sapiens)
Multiple proteins are localized at replication fork (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
Unwinding complex at replication fork [nucleoplasm] (Homo sapiens)
CDC45 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75419 CDC45
Gene Names
CDC45, CDC45L, CDC45L2, UNQ374/PRO710
Chain
chain:1-566
Reference Genes
BioGPS Gene:8318 CDC45
COSMIC (genes):CDC45 CDC45
CTD Gene:8318 CDC45
dbSNP Gene:8318 CDC45
ENSEMBL:ENSG00000093009 CDC45
HGNC:1739 CDC45
KEGG Gene (Homo sapiens):8318 CDC45
Monarch:8318 CDC45
NCBI Gene:8318 CDC45
OMIM:603465 CDC45
UCSC:O75419 CDC45
Reference Transcript
RefSeq:NM_001178011.2 CDC45
RefSeq:XM_011530418.2 CDC45
RefSeq:XM_005261285.2 CDC45
RefSeq:XM_011530415.1 CDC45
RefSeq:NM_001178010.2 CDC45
RefSeq:NM_003504.4 CDC45
Other Identifiers
0000380402
11719699_a_at
11745049_a_at
11751123_a_at
16927052
204126_s_at
37458_at
3936916
3936918
3936919
3936920
3936921
3936922
3936923
3936925
3936928
3936929
3936930
3936931
3936933
3936936
3936937
3936938
3936939
3936940
3936941
3936942
3936943
3936944
3936946
614
8071212
8318
9459
A_23_P57379
AAC27289
AAC67521
AAD08998
AAH06232
AAH10022
AAP35438
AAQ89330
AAS66985
AC000082
AC000087
AC000088
AF053074
AF062495
AF081535
AJ223728
AK293123
AK293338
AY358971
AY572790
BAG56675
BAG56854
BC006232
BC010022
BT006792
C9J911
C9K087
CAA11530
CAB009459
CAJ86443
CCDS13762
CCDS54499
CCDS54500
CDC45
CDC45-201
CDC45-202
CDC45-203
CDC45-205
CH471176
CT841513
EAX03036
ENSG00000093009
ENSP00000263201
ENSP00000384978
ENSP00000385240
ENSP00000405726
ENST00000263201
ENST00000263201.5
ENST00000404724
ENST00000404724.7
ENST00000407835
ENST00000407835.5
ENST00000437685
ENST00000437685.6
EntrezGene:8318
EntrezGene:CDC45
g4502712_3p_s_at
GE54724
GO:0000076
GO:0000082
GO:0000083
GO:0000228
GO:0000278
GO:0000727
GO:0003674
GO:0003677
GO:0003682
GO:0003688
GO:0003697
GO:0004386
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005656
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006259
GO:0006260
GO:0006270
GO:0006950
GO:0007049
GO:0008150
GO:0009058
GO:0022607
GO:0031261
GO:0031298
GO:0031938
GO:0032508
GO:0032991
GO:0034641
GO:0043138
GO:0043226
GO:0051276
GO:0065003
GO:1900087
GO:1902977
HGNC:1739
HPA000614
ILMN_1670238
ILMN_1808347
IPR003874
MIM:603465
MIM:617063
NM_001178010
NM_001178011
NM_003504
NP_001171481
NP_001171482
NP_003495
PF02724
PH_hs_0006287
PH_hs_0040528
TC22000046.hg
UPI0000000C75
UPI000042153E
UPI0000D4C86A
XM_011530416
XM_011530417
XM_011530418
XM_017028966
XM_024452277
XM_024452278
XP_011528718
XP_011528719
XP_011528720
XP_016884455
XP_024308045
XP_024308046
XR_002958715
XR_002958716
Participant Of
hasComponent
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm]
Unwinding complex at replication fork [nucleoplasm]
input
Cdc45 associates with the pre-replicative complex at the origin
Multiple proteins are localized at replication fork
output
CDC45 gene expression is stimulated by E2F1
Inferred To
CDC45 [nucleoplasm] (Bos taurus)
CDC45 [nucleoplasm] (Caenorhabditis elegans)
CDC45 [nucleoplasm] (Canis familiaris)
CDC45 [nucleoplasm] (Danio rerio)
CDC45 [nucleoplasm] (Dictyostelium discoideum)
CDC45 [nucleoplasm] (Drosophila melanogaster)
CDC45 [nucleoplasm] (Gallus gallus)
CDC45 [nucleoplasm] (Mus musculus)
CDC45 [nucleoplasm] (Rattus norvegicus)
CDC45 [nucleoplasm] (Saccharomyces cerevisiae)
CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDC45 [nucleoplasm] (Sus scrofa)
CDC45 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
XP_011528717.1
,
NP_001171482.1
,
NP_001171481.1
,
XP_005261342.1
,
NP_003495.1
,
XP_011528720.1
OpenTargets
ENSG00000093009
ZINC - Substances
CDC45_HUMAN
GeneCards
O75419
ZINC target
O75419
PRO
O75419
ZINC - Predictions - Purchasable
CDC45_HUMAN
Orphanet
23944
PDB
5DGO
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q53EZ4 CEP55
0.696
5
UniProt:P38936 CDKN1A
5
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
0.609
2
UniProt:Q9HAW4 CLSPN
5
CLSPN(1-1072) [nucleoplasm]
(R-HSA-351929)
PolyUb-CLSPN [nucleoplasm]
(R-HSA-6783087)
CLSPN(1073-1332) [nucleoplasm]
(R-HSA-351935)
CLSPN [nucleoplasm]
(R-HSA-176282)
p-T916,S945-CLSPN [nucleoplasm]
(R-HSA-176296)
0.576
4
UniProt:P15927 RPA2
2
RPA2 [nucleoplasm]
(R-HSA-68457)
p-S33-RPA2 [nucleoplasm]
(R-HSA-5685148)
0.576
4
UniProt:P49736 MCM2
1
MCM2 [nucleoplasm]
(R-HSA-68557)
0.574
2
IntAct:EBI-15634422 H3K9-2
0.544
2
UniProt:Q92547 TOPBP1
1
TOPBP1 [nucleoplasm]
(R-HSA-5684878)
0.544
6
UniProt:Q96D03 DDT4L
0.488
2
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.488
2
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