Reactome | CDC45 [nucleoplasm]

CDC45 [nucleoplasm]

Stable Identifier

R-HSA-68563

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cdc45, CDC45-related protein, PORC-PI-1

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75419 CDC45

Gene Names

CDC45, CDC45L, CDC45L2, UNQ374/PRO710

Chain

chain:1-566

Reference Genes

BioGPS Gene:8318 CDC45

COSMIC (genes):CDC45 CDC45

CTD Gene:8318 CDC45

dbSNP Gene:8318 CDC45

ENSEMBL:ENSG00000093009 CDC45

HGNC:1739 CDC45

KEGG:hsa:8318 CDC45

Monarch:8318 CDC45

NCBI Gene:8318 CDC45

OMIM:603465 CDC45

UCSC:O75419 CDC45

Reference Transcript

Other Identifiers

11719699_a_at

11745049_a_at

11751123_a_at

16927052

204126_PM_s_at

204126_s_at

37458_at

3936915

3936916

3936917

3936918

3936919

3936920

3936921

3936922

3936923

3936924

3936925

3936928

3936929

3936930

3936931

3936932

3936933

3936935

3936936

3936937

3936938

3936939

3936940

3936941

3936942

3936943

3936944

3936946

8071212

8318

A_14_P127995

A_23_P57379

GE54724

GO:0000076

GO:0000727

GO:0003677

GO:0003682

GO:0003688

GO:0003697

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005813

GO:0005815

GO:0006260

GO:0006268

GO:0006270

GO:0006281

GO:0006310

GO:0031261

GO:0036064

GO:0043226

GO:0065003

GO:0071162

GO:1902977

HMNXSV003005201

ILMN_1670238

PH_hs_0006287

PH_hs_0040528

TC22000046.hg

g4502712_3p_s_at

Participates

as a component of

as an input of

as an output of

CDC45 gene expression is stimulated by E2F1 (Homo sapiens)

Inferred To

cdc45 [nucleoplasm] (Danio rerio)

cdc45 [nucleoplasm] (Dictyostelium discoideum)

CDC45 [nucleoplasm] (Bos taurus)

CDC45 [nucleoplasm] (Canis familiaris)

CDC45 [nucleoplasm] (Gallus gallus)

CDC45 [nucleoplasm] (Saccharomyces cerevisiae)

CDC45 [nucleoplasm] (Sus scrofa)

evl-18 [nucleoplasm] (Caenorhabditis elegans)

sna41 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of CDC45 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of CDC45 [nucleoplasm] (Xenopus tropicalis)

Cdc45 [nucleoplasm] (Drosophila melanogaster)

Cdc45 [nucleoplasm] (Mus musculus)

Cross References

RefSeq

NP_003495.1, XP_011528717.1, XP_005261342.1, NP_001171481.1, NP_001171482.1, XP_011528720.1

OpenTargets

ENSG00000093009

ENSEMBL

ENSP00000384978, ENSP00000405726, ENST00000263201, ENSP00000263201, ENST00000437685, ENST00000404724

HPA

ENSG00000093009-CDC45

ZINC - Substances

CDC45_HUMAN

ZINC target

O75419

PRO

O75419

Pharos - Targets

O75419

Orphanet

CDC45

GlyGen

O75419

ZINC - Predictions - Purchasable

CDC45_HUMAN

PDB

7PLO, 5DGO, 6XTX, 6XTY, 7PFO

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q53EZ4 CEP55			0.781	7
UniProt:Q9HAW4 CLSPN	5	PolyUb-CLSPN [nucleoplasm] (R-HSA-6783087) CLSPN(1-1072) [nucleoplasm] (R-HSA-351929) CLSPN(1073-1332) [nucleoplasm] (R-HSA-351935) CLSPN [nucleoplasm] (R-HSA-176282) p-T916,S945-CLSPN [nucleoplasm] (R-HSA-176296)	0.677	5
UniProt:Q14691 GINS1	1	GINS1 [nucleoplasm] (R-HSA-176955)	0.623	4
UniProt:P15927 RPA2	2	RPA2 [nucleoplasm] (R-HSA-68457) p-S33-RPA2 [nucleoplasm] (R-HSA-5685148)	0.576	4
UniProt:Q9BRT9 GINS4	1	GINS4 [nucleoplasm] (R-HSA-176963)	0.574	3
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.574	2
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.571	2
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:P61018 RAB4B	5	GGC-RAB4B [cytosol] (R-HSA-8874049) RAB4B [cytosol] (R-HSA-8873680) GGC-RAB4B [recycling endosome membrane] (R-HSA-8875675) RAB4B [plasma membrane] (R-HSA-6804989) RAB4B [secretory granule membrane] (R-HSA-6804976)	0.556	3
UniProt:Q92547 TOPBP1	1	TOPBP1 [nucleoplasm] (R-HSA-5684878)	0.544	6
IntAct:EBI-15634422 H3K9-2			0.544	2
UniProt:Q9NYP3 DONS			0.504	5