Reactome | TFDP1 [nucleoplasm]

TFDP1 [nucleoplasm]

Stable Identifier

R-HSA-68652

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DP-1, Transcription factor DP-1 (E2F dimerization partner 1)(DRTF1-polypeptide-1) (DRTF1), Transcription factor Dp-1, E2F dimerization partner 1, DRTF1- polypeptide-1, DRTF1

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
      - Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
        
        Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
        
        E2F1,(E2F2,E2F3):TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
        
        TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
        
        TFDP1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14186 TFDP1

Gene Names

TFDP1, DP1

Chain

chain:1-410

Reference Genes

BioGPS Gene:7027 TFDP1

COSMIC (genes):TFDP1 TFDP1

CTD Gene:7027 TFDP1

dbSNP Gene:7027 TFDP1

ENSEMBL:ENSG00000198176 TFDP1

HGNC:11749 TFDP1

KEGG:hsa:7027 TFDP1

Monarch:7027 TFDP1

NCBI Gene:7027 TFDP1

OMIM:189902 TFDP1

UCSC:Q14186 TFDP1

Reference Transcript

Other Identifiers

11725347_a_at

11725348_x_at

11725349_s_at

11748055_x_at

11761840_at

1670_at

16776905

204147_PM_s_at

204147_s_at

212330_PM_at

212330_at

2377917

2377918

2377920

242939_PM_at

242939_at

3502711

3502712

3502713

3502714

3502715

3502716

3502717

3502718

3502719

3502720

3502739

3502751

3502763

3502764

3502765

3502766

3502767

3502768

3502769

3502770

3502773

3502774

3502775

3502776

3502777

3502778

3502779

3502785

3502786

3502787

3502788

3502789

3502790

3502791

3502792

3502793

3635028

3635033

3635034

3635036

3635038

37757_at

67226_at

7027

7970317

A_32_P199301

A_33_P3384452

GE57682

GO:0000785

GO:0000977

GO:0000981

GO:0000987

GO:0001228

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0008544

GO:0012501

GO:0019904

GO:0035189

GO:0043226

GO:0043276

GO:0045893

GO:0045944

GO:0048856

GO:0051091

GO:0051726

GO:0070345

GO:0090575

GO:0140110

GO:0140297

GO:1900087

GO:2000278

HMNXSV003048800

Hs.182269.0.A1_3p_at

Hs.79353.2.A1_3p_at

ILMN_1661717

ILMN_2117987

L23959_at

PH_hs_0004593

PH_hs_0031354

TC13000426.hg

TC13001318.hg

g6005899_3p_s_at

Participates

as an input of

E2F6 binds TFDP1 (Homo sapiens)

as a component of

E2F6:TFDP1 [nucleoplasm] (Homo sapiens)

as a candidate of

(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)

as a member of

TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)

Inferred To

TFDP1 [nucleoplasm] (Bos taurus)

TFDP1 [nucleoplasm] (Canis familiaris)

TFDP1 [nucleoplasm] (Gallus gallus)

TFDP1 [nucleoplasm] (Sus scrofa)

tfdp1 [nucleoplasm] (Xenopus tropicalis)

dpl-1 [nucleoplasm] (Caenorhabditis elegans)

tfdp2 [nucleoplasm] (Dictyostelium discoideum)

tfdp1a [nucleoplasm] (Danio rerio)

Dp [nucleoplasm] (Drosophila melanogaster)

Tfdp1 [nucleoplasm] (Mus musculus)

Tfdp1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_005268388.1, NP_009042.1, XP_005268384.1

OpenTargets

ENSG00000198176

ENSEMBL

ENST00000375370, ENSG00000198176, ENSP00000364519

HPA

ENSG00000198176-TFDP1

GeneCards

TFDP1

PRO

Q14186

Pharos - Targets

Q14186

PDB

5GOW, 5TUV, 2AZE, 5TUU

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.953	24
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.95	17
UniProt:Q16254 E2F4	1	E2F4 [nucleoplasm] (R-HSA-68664)	0.806	7
UniProt:P61244 MAX	1	MAX [nucleoplasm] (R-HSA-3006627)	0.773	7
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.744	6
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.725	6
UniProt:Q14209 E2F2	1	E2F2 [nucleoplasm] (R-HSA-68649)	0.659	3
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.643	3
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.643	6
UniProt:Q8N668 COMMD1	2	COMMD1 [nucleoplasm] (R-HSA-8955094) COMMD1 [cytosol] (R-HSA-8955110)	0.643	4
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.643	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.643	4
UniProt:Q9H0A8 COMMD4	2	COMMD4 [nucleoplasm] (R-HSA-8955106) COMMD4 [cytosol] (R-HSA-8955111)	0.643	4
UniProt:Q8IY57 YAF2	1	YAF2 [nucleoplasm] (R-HSA-8937973)	0.643	3
UniProt:Q9NX08 COMMD8	2	COMMD8 [nucleoplasm] (R-HSA-8955102) COMMD8 [cytosol] (R-HSA-8955107)	0.643	4
UniProt:Q15329 E2F5	1	E2F5 [nucleoplasm] (R-HSA-68669)	0.527	2
UniProt:Q7Z4G1 COMMD6	2	COMMD6 [nucleoplasm] (R-HSA-8955097) COMMD6 [cytosol] (R-HSA-8955098)	0.527	3
UniProt:Q5TKA1 LIN9	1	LIN9 [nucleoplasm] (R-HSA-389108)	0.527	2
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	2
UniProt:Q8N344 MIER2			0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	3
UniProt:Q96GY3 LIN37	1	LIN37 [nucleoplasm] (R-HSA-389101)	0.527	2
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.527	2
UniProt:O00716 E2F3	2	p-E2F3 [nucleoplasm] (R-HSA-187933) E2F3 [nucleoplasm] (R-HSA-68655)	0.527	2
UniProt:Q8IWI9 MGA	1	MGA [nucleoplasm] (R-HSA-8953093)	0.527	2
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.527	3
UniProt:Q9UJY5 GGA1	2	GGA1 [endosome membrane] (R-HSA-5692930) GGA1 [early endosome membrane] (R-HSA-8854136)	0.527	2
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.527	3
UniProt:O14640 DVL1	4	pp-DVL1 [cytosol] (R-HSA-3772396) p-S-DVL1 [cytosol] (R-HSA-201700) DVL1 [cytosol] (R-HSA-201687) ub-DVL1 [cytosol] (R-HSA-4641157)	0.463	3
UniProt:Q08999 RBL2	2	RBL2 [nucleoplasm] (R-HSA-389102) p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084)	0.462	4

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