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E2F1:TFDP1,TFDP2 [nucleoplasm]
Stable Identifier
R-HSA-68653
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DP1/2:E2F1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G0 and Early G1 (Homo sapiens)
Transcription of E2F targets under negative control by DREAM complex (Homo sapiens)
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC6 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:PCNA gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 (Homo sapiens)
CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDK1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F mediated regulation of DNA replication (Homo sapiens)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Homo sapiens)
Replication initiation regulation by Rb1/E2F1 (Homo sapiens)
Aborted replication complex [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
CCNA1 gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CCNA1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
CCNE1 gene transcription is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CCNE1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
CDC45 gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC45 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC6 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDK1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
CDT1 gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDT1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
DHFR gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:DHFR gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the CCNA1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CCNA1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the CCNE1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CCNE1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the CDC25A gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the CDC45 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC45 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the CDC6 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC6 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the CDK1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDK1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the CDT1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDT1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the DHFR gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:DHFR gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the FBXO5 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:FBXO5 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the ORC1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:ORC1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the PCNA gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:PCNA gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the POLA1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:POLA1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the RRM2 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:RRM2 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 binds the TK1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:TK1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
FBXO5 gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:FBXO5 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
ORC1 gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:ORC1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:PCNA gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
POLA1 gene transcription is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:POLA1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:RRM2 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
TK1 gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:TK1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
TYMS gene expression (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:RRM2 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of NOXA and translocation to mitochondria (Homo sapiens)
E2F1 binds PMAIP1 (NOXA) promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1:PMAIP1 Gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
Transactivation of PMAIP1 (NOXA) by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1:PMAIP1 Gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
Activation of PUMA and translocation to mitochondria (Homo sapiens)
E2F1 binds BBC3 (PUMA) promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1:BBC3 Gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
Transactivation of BBC3 (PUMA) by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1:BBC3 Gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
Participants
components
E2F1 [nucleoplasm]
(Homo sapiens)
TFDP1,TFDP2 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
E2F1:TFDP1,TFDP2:CCNA1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:POLA1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDT1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:FBXO5 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:Tk1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:TK1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CCNE1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC45 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC6 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:PCNA gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDK1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1:PMAIP1 Gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1:BBC3 Gene [nucleoplasm] (Homo sapiens)
Aborted replication complex [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:RRM2 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:ORC1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:DHFR gene [nucleoplasm] (Homo sapiens)
as an input of
E2F1 binds the CCNA1 gene promoter (Homo sapiens)
E2F1 binds the POLA1 gene promoter (Homo sapiens)
E2F1 binds the CDT1 gene promoter (Homo sapiens)
E2F1 binds the FBXO5 gene promoter (Homo sapiens)
E2F1 binds the Tk1 gene promoter (Homo sapiens)
E2F1 binds the CCNE1 gene promoter (Homo sapiens)
E2F1 binds the CDC25A gene promoter (Homo sapiens)
E2F1 binds the CDC45 gene promoter (Homo sapiens)
E2F1 binds the CDC6 gene promoter (Homo sapiens)
E2F1 binds the PCNA gene promoter (Homo sapiens)
E2F1 binds the CDK1 gene promoter (Homo sapiens)
E2F1 binds PMAIP1 (NOXA) promoter (Homo sapiens)
E2F1 binds BBC3 (PUMA) promoter (Homo sapiens)
Replication initiation regulation by Rb1/E2F1 (Homo sapiens)
E2F1 binds the RRM2 gene promoter (Homo sapiens)
E2F1 binds the ORC1 gene promoter (Homo sapiens)
E2F1 binds the DHFR gene promoter (Homo sapiens)
E2F1 binds the TK1 gene promoter (Homo sapiens)
This entity regulates
Positively
TYMS gene expression
(Homo sapiens)
Inferred To
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm]
(Dictyostelium discoideum)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm]
(Drosophila melanogaster)
E2F1:TFDP1,TFDP2 [nucleoplasm]
(Bos taurus)
E2F1:TFDP1,TFDP2 [nucleoplasm]
(Canis familiaris)
E2F1:TFDP1,TFDP2 [nucleoplasm]
(Gallus gallus)
E2F1:TFDP1,TFDP2 [nucleoplasm]
(Mus musculus)
E2F1:TFDP1,TFDP2 [nucleoplasm]
(Rattus norvegicus)
E2F1:TFDP1,TFDP2 [nucleoplasm]
(Sus scrofa)
E2F1:TFDP1,TFDP2 [nucleoplasm]
(Xenopus tropicalis)
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