Reactome | E2F3 [nucleoplasm]

E2F3 [nucleoplasm]

Stable Identifier

R-HSA-68655

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor E2F3, E2F-3, E2F3a

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
      - Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
        
        Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
        
        E2F1,(E2F2,E2F3):TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
        
        E2F1,(E2F2,E2F3) [nucleoplasm] (Homo sapiens)
        
        E2F3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00716 E2F3

Gene Names

E2F3, KIAA0075

Chain

chain:1-465

Reference Genes

BioGPS Gene:1871 E2F3

COSMIC (genes):E2F3 E2F3

CTD Gene:1871 E2F3

dbSNP Gene:1871 E2F3

ENSEMBL:ENSG00000112242 E2F3

HGNC:3115 E2F3

KEGG:hsa:1871 E2F3

Monarch:1871 E2F3

NCBI Gene:1871 E2F3

OMIM:600427 E2F3

UCSC:O00716 E2F3

Reference Transcript

Other Identifiers

11742800_s_at

11752100_s_at

11754266_s_at

17005234

1871

203692_PM_s_at

203692_s_at

203693_PM_s_at

203693_s_at

2593109

2897580

2897581

2897582

2897583

2897606

2897607

2897608

2897614

2897615

2897616

2897617

2897618

2897619

2897620

2897621

2897622

2897623

3718642

3718643

41632_at

8117128

A_23_P385034

A_33_P3418516

D38550_at

GE57194

GO:0000082

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0000987

GO:0001216

GO:0001228

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0006355

GO:0006357

GO:0006367

GO:0006606

GO:0006886

GO:0006913

GO:0008284

GO:0043226

GO:0043565

GO:0045893

GO:0045944

GO:0046983

GO:0070345

GO:0090575

GO:0140110

GO:1905461

GO:1990837

HMNXSV003015946

Hs.1189.0.A1_3p_a_at

ILMN_1669502

PH_hs_0027029

TC06000128.hg

g12669913_3p_a_at

Participates

as a candidate of

E2F1,(E2F2,E2F3) [nucleoplasm] (Homo sapiens)

as a member of

Other forms of this molecule

p-E2F3 [nucleoplasm]

Inferred To

E2F3 [nucleoplasm] (Bos taurus)

E2F3 [nucleoplasm] (Canis familiaris)

E2F3 [nucleoplasm] (Gallus gallus)

E2F3 [nucleoplasm] (Sus scrofa)

E2f3 [nucleoplasm] (Mus musculus)

E2f3 [nucleoplasm] (Rattus norvegicus)

E2F [nucleoplasm] (Dictyostelium discoideum)

e2f3 [nucleoplasm] (Xenopus tropicalis)

E2f1 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001230005.1, NP_001940.1

ENSEMBL

ENSP00000443418, ENST00000346618, ENSP00000262904, ENST00000535432

OpenTargets

ENSG00000112242

HPA

ENSG00000112242-E2F3

PRO

O00716

Pharos - Targets

O00716

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.822	5
UniProt:Q14188 TFDP2	1	TFDP2 [nucleoplasm] (R-HSA-1362225)	0.527	3
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.527	2
UniProt:Q9NRZ9 HELLS	1	HELLS [nucleoplasm] (R-HSA-9839382)	0.499	2
UniProt:P43246 MSH2	3	MSH2 [nucleoplasm] (R-HSA-5357525) MSH2 GLN601TER [nucleoplasm] (R-HSA-5577243) MSH2 R406* [nucleoplasm] (R-HSA-5575594)	0.483	2