Reactome | E2F4 [nucleoplasm]

E2F4 [nucleoplasm]

Stable Identifier

R-HSA-68664

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor E2F4 (E2F-4) , Transcription factor E2F4, E2F-4

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q16254 E2F4

Gene Names

E2F4

Chain

initiator methionine:, chain:2-413

Reference Genes

BioGPS Gene:1874 E2F4

COSMIC (genes):E2F4 E2F4

CTD Gene:1874 E2F4

dbSNP Gene:1874 E2F4

ENSEMBL:ENSG00000205250 E2F4

HGNC:3118 E2F4

KEGG:hsa:1874 E2F4

Monarch:1874 E2F4

NCBI Gene:1874 E2F4

OMIM:600659 E2F4

UCSC:Q16254 E2F4

Reference Transcript

RefSeq:NM_001950.3 E2F4

Other Identifiers

11716215_at

11716216_at

16820041

1703_g_at

1874

202248_PM_at

202248_at

3665290

3665291

3665292

3665293

3665294

3665295

3665296

3665297

3665298

3665299

3665300

3665301

3665302

3665303

3665304

3665305

3665306

3665307

3665308

3665310

3665311

3665312

3665313

3665314

3665316

3665317

3665318

3665319

3665320

3665321

3665322

3665323

3665324

3665325

3665326

38706_at

38707_3p_r_at

38707_PM_r_at

38707_r_at

7996455

A_14_P100071

A_14_P121955

A_23_P152218

A_24_P318457

GE61132

GE770050

GO:0000785

GO:0000978

GO:0000981

GO:0001216

GO:0001228

GO:0002064

GO:0003013

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0006355

GO:0006357

GO:0006884

GO:0008015

GO:0008361

GO:0009887

GO:0019904

GO:0030030

GO:0030154

GO:0042127

GO:0043226

GO:0044458

GO:0044782

GO:0045944

GO:0046983

GO:0048856

GO:0060271

GO:0090575

GO:0098534

GO:0140110

GO:1903251

GO:1990837

GO:1990841

HMNXSV003007154

ILMN_1761828

PH_hs_0006003

TC16000533.hg

U15641_s_at

g12652720_3p_at

Participates

as a component of

as a member of

E2F4,E2F5 [nucleoplasm] (Homo sapiens)

Inferred To

E2f2 [nucleoplasm] (Drosophila melanogaster)

E2F [nucleoplasm] (Dictyostelium discoideum)

E2F4 [nucleoplasm] (Bos taurus)

E2F4 [nucleoplasm] (Canis familiaris)

E2F4 [nucleoplasm] (Gallus gallus)

E2F4 [nucleoplasm] (Sus scrofa)

efl-1 [nucleoplasm] (Caenorhabditis elegans)

E2f4 [nucleoplasm] (Mus musculus)

E2f4 [nucleoplasm] (Rattus norvegicus)

e2f4 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001941.2

ENSEMBL

ENSP00000368686, ENST00000379378

OpenTargets

ENSG00000205250

HPA

ENSG00000205250-E2F4

PRO

Q16254

Pharos - Targets

Q16254

GlyGen

Q16254

PDB

1CF7, 5TUU

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.806	7
UniProt:Q14188 TFDP2	1	TFDP2 [nucleoplasm] (R-HSA-1362225)	0.77	5
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.757	6
UniProt:Q08999 RBL2	2	RBL2 [nucleoplasm] (R-HSA-389102) p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084)	0.748	8
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P11802 CDK4	3	p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [nucleoplasm] (R-HSA-113843) CDK4 [cytosol] (R-HSA-68330)	0.534	2
UniProt:P01189 POMC	12	POMC(237-241) [extracellular region] (R-HSA-167407) POMC(237-267) [extracellular region] (R-HSA-167405) POMC(138-176) [extracellular region] (R-HSA-388607) POMC(138-150) [extracellular region] (R-HSA-388593) POMC(217-234) [extracellular region] (R-HSA-388617) POMC(77-87) [extracellular region] (R-HSA-388618) POMC(138-176) [cytosol] (R-HSA-1502544) POMC(138-176) K25* [extracellular region] (R-HSA-5623536) POMC(138-176) E79* [extracellular region] (R-HSA-5623539) POMC(138-176) R236G [extracellular region] (R-HSA-5603387) POMC(1-241) [secretory granule lumen] (R-HSA-378943) POMC(138-176) [secretory granule lumen] (R-HSA-378965)	0.527	2
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.527	2
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.527	2

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