The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1

Stable Identifier
R-HSA-68712
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the beginning of this reaction, 1 molecule of 'ubiquitin', and 1 molecule of 'Cdt1:geminin' are present. At the end of this reaction, 1 molecule of 'geminin:ubiquitin complex', and 1 molecule of 'Cdt1' are present.

This reaction takes place in the 'cytosol'.

Literature References
PubMed ID Title Journal Year
11125146 Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.

Wohlschlegel, JA, Dwyer, BT, Dhar, SK, Cvetic, C, Walter, JC, Dutta, A

Science 2000
9635433 Geminin, an inhibitor of DNA replication, is degraded during mitosis.

McGarry, TJ, Kirschner, MW

Cell 1998
Participants
Participant Of
Orthologous Events
Created