Reactome | PSMA4 [cytosol]

PSMA4 [cytosol]

Stable Identifier

R-HSA-68730

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasome subunit alpha-3

Locations in the PathwayBrowser for interactor UniProt:Q13422 IKZF1

Expand all

External Reference Information

External Reference

UniProt:P25789 PSMA4

Gene Names

PSMA4, HC9, PSC9

Chain

chain:1-261

Reference Genes

BioGPS Gene:5685 PSMA4

COSMIC (genes):PSMA4 PSMA4

CTD Gene:5685 PSMA4

dbSNP Gene:5685 PSMA4

ENSEMBL:ENSG00000041357 PSMA4

ENSEMBL_homo_sapiens_GENE:ENSG00000041357.16 PSMA4

HGNC:9533 PSMA4

KEGG Gene (Homo sapiens):5685 PSMA4

Monarch:5685 PSMA4

NCBI Gene:5685 PSMA4

OMIM:176846 PSMA4

UCSC:P25789 PSMA4

Reference Transcript

Other Identifiers

11721905_a_at

11721906_s_at

11742892_s_at

1449_at

1450_g_at

16803540

203396_PM_at

203396_at

3603411

3603412

3603413

3603418

3603420

3603421

3603422

3603423

3603425

3603426

3603427

3603428

3603429

3603430

3603431

3603433

47202_at

5685

7985202

A_24_P124992

D00763_at

GE62733

GO:0000502

GO:0000932

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006511

GO:0010498

GO:0019773

GO:0030163

GO:0043161

GO:0043226

GO:0043231

GO:0051603

GO:0070062

HMNXSV003000223

ILMN_1682098

ILMN_2198376

TC15000731.hg

g4506184_3p_at

Participates

as an input of

Formation of the outer ring of the 20S core particle (Homo sapiens)

as a component of

20S CP outer ring [cytosol] (Homo sapiens)

Other forms of this molecule

PSMA4 [nucleoplasm]

Inferred To

bPSMA4 [cytosol] (Bos taurus)

Prosalpha3 [cytosol] (Drosophila melanogaster)

psmA4 [cytosol] (Dictyostelium discoideum)

PSMA4 [cytosol] (Canis familiaris)

PSMA4 [cytosol] (Gallus gallus)

PSMA4 [cytosol] (Plasmodium falciparum)

PSMA4 [cytosol] (Schizosaccharomyces pombe)

PSMA4 [cytosol] (Sus scrofa)

pas-3 [cytosol] (Caenorhabditis elegans)

Psma4 [cytosol] (Mus musculus)

Psma4 [cytosol] (Rattus norvegicus)

psma4 [cytosol] (Danio rerio)

psma4 [cytosol] (Xenopus tropicalis)

PRE9 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001096137.1, NP_002780.1, NP_001317605.1, NP_001096138.1

OpenTargets

ENSG00000041357

GeneCards

P25789

HPA

ENSG00000041357-PSMA4

Ensembl

ENST00000559082, ENSP00000044462, ENSG00000041357, ENSP00000402118, ENST00000413382, ENSP00000453887, ENST00000044462

PRO

P25789

Pharos - Targets

P25789

PDB

7W3F, 5LF3, 7NAP, 7QXX, 5LF6, 8BZL, 5LN3, 5T0C, 7PG9, 4R67, 5LF4, 7QXW, 5LE5, 7NAO, 7W3B, 8CVS, 7W3H, 7B12, 7W37, 8QYL, 7V5G, 5M32, 8CXB, 5T0H, 8CVR, 6WJD, 6MSK, 8QYJ, 5T0G, 5LF7, 5VFP, 7QYB, 5T0I, 5VFO, 5VFQ, 6MSB, 7W3I, 5GJQ, 5LEY, 7W3M, 6KWY, 7W3A, 8QYS, 6MSE, 6AVO, 5VFT, 7QXU, 5LEX, 6REY, 5GJR, 5VFR, 4R3O, 5LEZ, 8QYO, 6MSD, 7QXP, 6MSH, 8QZ9, 6MSJ, 6MSG, 7W3C, 6XMJ, 5VFU, 5L4G, 7LXV, 6R70, 7NAQ, 7QY7, 7W3G, 7W3J, 7W39, 8QYN, 8UD9, 7QXN, 7V5M, 6WJN, 8CVT, 7QYA, 7W38, 8QYM, 5T0J, 6RGQ, 5VFS, 6E5B, 5LF0, 7NAN, 7AWE, 5LF1, 7W3K, 7NHT, 5A0Q

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.916	14
UniProt:P25787 PSMA2	5	PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [cytosol] (R-HSA-68726)	0.908	12
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.884	12
UniProt:P60900 PSMA6	2	PSMA6 [nucleoplasm] (R-HSA-174314) PSMA6 [cytosol] (R-HSA-68734)	0.669	5
UniProt:P28066 PSMA5	5	PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [cytosol] (R-HSA-68732)	0.669	5
UniProt:P54253 ATX1			0.666	7
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:Q99436 PSMB7	7	PSMB7(1-43) [cytosol] (R-HSA-9908129) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [cytosol] (R-HSA-68759)	0.643	9
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:P49721 PSMB2	2	PSMB2 [nucleoplasm] (R-HSA-174335) PSMB2 [cytosol] (R-HSA-68744)	0.643	4
UniProt:P20618 PSMB1	7	PSMB1(1-28) [cytosol] (R-HSA-9908143) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [cytosol] (R-HSA-68738)	0.643	4
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.576	4
UniProt:P25788 PSMA3	2	PSMA3 [nucleoplasm] (R-HSA-174323) PSMA3 [cytosol] (R-HSA-68728)	0.573	4
UniProt:O00635 TRIM38	1	TRIM38 [cytosol] (R-HSA-5624325)	0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q13422 IKZF1			0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.547	2
UniProt:P28070 PSMB4	4	PSMB4(1-45) [cytosol] (R-HSA-9908122) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4 [nucleoplasm] (R-HSA-174343) PSMB4 [cytosol] (R-HSA-68750)	0.527	3
UniProt:P49720 PSMB3	2	PSMB3 [nucleoplasm] (R-HSA-174341) PSMB3 [cytosol] (R-HSA-68747)	0.527	4
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.527	3
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.527	3
UniProt:P28065 PSMB9	3	PSMB9(1-20) [cytosol] (R-HSA-9908132) PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136)	0.527	4
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.495	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10

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