Reactome | PSMB5 [cytosol]

PSMB5 [cytosol]

Stable Identifier

R-HSA-68753

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasome subunit beta-5, Proteasome subunit beta-5 precursor

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P28074 PSMB5

Gene Names

PSMB5, LMPX, MB1, X

Chain

propeptide:1-59, chain:60-263

Reference Genes

BioGPS Gene:5693 PSMB5

COSMIC (genes):PSMB5 PSMB5

CTD Gene:5693 PSMB5

dbSNP Gene:5693 PSMB5

ENSEMBL:ENSG00000100804 PSMB5

HGNC:9542 PSMB5

KEGG:hsa:5693 PSMB5

Monarch:5693 PSMB5

NCBI Gene:5693 PSMB5

OMIM:600306 PSMB5

UCSC:P28074 PSMB5

Reference Transcript

Other Identifiers

11717105_a_at

11717106_x_at

11719787_x_at

11732666_s_at

11754009_a_at

16790659

208799_PM_at

208799_at

3557049

3557052

3557053

3557054

3557055

3557056

3557057

3557058

3557059

3557061

37666_at

5693

7977879

A_23_P37191

GE79699

GO:0000502

GO:0003824

GO:0004175

GO:0004298

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005839

GO:0006508

GO:0006979

GO:0008233

GO:0016787

GO:0019774

GO:0030163

GO:0043161

GO:0043226

GO:0051603

GO:0070062

GO:0140096

HMNXSV003021336

HMNXSV003046393

ILMN_1744649

PH_hs_0019777

TC14000946.hg

X95586_at

g13278740_3p_at

Participates

as a component of

20S CP inner ring [cytosol] (Homo sapiens)

Other forms of this molecule

PSMB5 [nucleoplasm]

pro-PSMB5 [cytosol]

PSMB5(1-59) [cytosol]

Inferred To

PSMB5 [cytosol] (Canis familiaris)

PSMB5 [cytosol] (Mus musculus)

PSMB5 [cytosol] (Plasmodium falciparum)

PSMB5 [cytosol] (Rattus norvegicus)

PSMB5 [cytosol] (Saccharomyces cerevisiae)

PSMB5 [cytosol] (Sus scrofa)

pbs-5 [cytosol] (Caenorhabditis elegans)

psmb5 [cytosol] (Danio rerio)

psmB5 [cytosol] (Dictyostelium discoideum)

pts1 [cytosol] (Schizosaccharomyces pombe)

Prosbeta5 [cytosol] (Drosophila melanogaster)

Ghost homologue of PSMB5 [cytosol] (Gallus gallus)

Ghost homologue of PSMB5 [cytosol] (Xenopus tropicalis)

bPSMB5 [cytosol] (Bos taurus)

Cross References

RefSeq

NP_002788.1, NP_001124197.1, NP_001138404.1

Guide to Pharmacology - Targets

2406

OpenTargets

ENSG00000100804

ENSEMBL

ENST00000493471, ENSP00000452424, ENSP00000355325, ENST00000425762, ENSG00000100804, ENST00000361611, ENSP00000395206

ZINC - FDA approved

PSB5_HUMAN

ZINC - Substances

PSB5_HUMAN

ZINC - Biogenic

PSB5_HUMAN

ZINC target

P28074

PRO

P28074

GlyGen

P28074

PDB

7W37, 5M32, 6MSG, 6WJN, 7QXW, 5T0G, 7W3K, 7W3M, 7QXN, 7QXP, 5T0J, 6MSE, 8QYS, 8QYO, 8CVT, 5GJQ, 7QYB, 5L4G, 8CVR, 5LF3, 5LEX, 5LF1, 5LF7, 7NAQ, 7NAP, 7LXV, 6REY, 5VFO, 5L5Z, 5L62, 5L5Y, 6WJD, 5L61, 5L5X, 5L5W, 5L60, 7V5M, 8QZ9, 5VFS, 6RGQ, 5VFP, 5VFQ, 6MSK, 7W3G, 7QXU, 5LN3, 7W3I, 6MSH, 4R3O, 7W38, 5GJR, 7W39, 7NAN, 5T0H, 7W3F, 8BZL, 5T0I, 7QXX, 6MSD, 7W3C, 7QY7, 7V5G, 5T0C, 8QYN, 7PG9, 6KWY, 7QYA, 5LE5, 7NHT, 5LEZ, 5LF4, 5LEY, 4R67, 6R70, 7NAO, 5LF6, 8TM6, 8UD9, 5A0Q, 5L64, 5L63, 5LF0, 8CXB, 5VFU, 5VFT, 7W3B, 5VFR, 7W3H, 7W3J, 6MSJ, 7W3A, 6XMJ, 6MSB, 8CVS

ZINC - Investigational

PSB5_HUMAN

HPA

ENSG00000100804-PSMB5

GeneCards

PSMB5

Pharos - Targets

P28074

ZINC - Predictions - Purchasable

PSB5_HUMAN

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [secretory granule lumen] (R-HSA-6803279)	0.804	10
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [secretory granule lumen] (R-HSA-6803287)	0.804	7
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.794	9
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.745	6
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.738	5
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [secretory granule lumen] (R-HSA-6803329)	0.725	6
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.667	4
UniProt:O15116 LSM1	1	LSM1 [cytosol] (R-HSA-429976)	0.666	4
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.659	4
UniProt:P28065 PSMB9	3	PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.643	5
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.589	2
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [secretory granule lumen] (R-HSA-6801036)	0.564	2
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	5
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q68J44 DUS29			0.556	3
IntAct:EBI-18719940 GG12G			0.556	3
UniProt:Q9BT92 TCHP			0.556	3
UniProt:Q92989 CLP1	1	CLP1 [nucleoplasm] (R-HSA-72017)	0.556	3
UniProt:Q8NCX0-3 CCDC150			0.556	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [secretory granule lumen] (R-HSA-6803316)	0.527	4
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.527	2
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.495	2

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