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PSMC1 [cytosol]
Stable Identifier
R-HSA-68768
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
26S protease regulatory subunit 4, P26s4, 6S proteasome AAA-ATPase subunit RPT2
Locations in the PathwayBrowser for interactor UniProt:P01106 MYC
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Proteasome assembly (Homo sapiens)
PSMC2 binds PSMC1 (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62191 PSMC1
Gene Names
PSMC1
Chain
initiator methionine:1, chain:2-440
Reference Genes
BioGPS Gene:5700 PSMC1
COSMIC (genes):PSMC1 PSMC1
CTD Gene:5700 PSMC1
dbSNP Gene:5700 PSMC1
ENSEMBL:ENSG00000100764 PSMC1
HGNC:9547 PSMC1
KEGG:hsa:5700 PSMC1
Monarch:5700 PSMC1
NCBI Gene:5700 PSMC1
OMIM:602706 PSMC1
UCSC:P62191 PSMC1
Reference Transcript
RefSeq:XM_017021470.1 PSMC1
RefSeq:NM_002802.2 PSMC1
RefSeq:XM_054376421.1 PSMC1
RefSeq:NM_001330212.2 PSMC1
Other Identifiers
11716545_x_at
11748303_x_at
16787409
204219_3p_s_at
204219_PM_s_at
204219_s_at
2471205
2471210
2628584
2628585
2628586
2628587
2628588
2628589
2628590
2628591
2628592
2628593
2703461
2822886
2822887
2822888
2869838
3026199
3406993
3406995
3406997
3407003
3407007
3548281
3548286
3548287
3548288
3548290
3548291
3548292
3548293
3548295
3548298
3548299
3548300
3548301
3548302
3548303
3548307
3548308
3548310
3548312
3548314
3548316
3548317
3548318
3548320
3548322
3548324
5700
688_at
7976189
8080923
A_14_P118170
A_24_P347488
A_32_P57870
A_32_P9700
GE61348
GO:0000166
GO:0000502
GO:0003723
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005838
GO:0008540
GO:0016020
GO:0016787
GO:0016887
GO:0022624
GO:0030163
GO:0036402
GO:0043161
GO:1901800
HMNXSV003052549
ILMN_1710406
ILMN_1721659
ILMN_1736353
L02426_at
PH_hs_0032853
TC14000552.hg
g4506206_3p_a_at
g4506206_3p_s_at
Participates
as an input of
PSMC2 binds PSMC1 (Homo sapiens)
as a component of
Deglycosylation complex [endoplasmic reticulum membrane] (Homo sapiens)
PSMC2:PSMC1 [cytosol] (Homo sapiens)
Other forms of this molecule
PSMC1 [nucleoplasm]
Inferred To
Homologues of PSMC1 [cytosol]
(Canis familiaris)
Psmc1 [cytosol]
(Mus musculus)
Psmc1 [cytosol]
(Rattus norvegicus)
PSMC1 [cytosol]
(Bos taurus)
PSMC1 [cytosol]
(Canis familiaris)
PSMC1 [cytosol]
(Gallus gallus)
PSMC1 [cytosol]
(Plasmodium falciparum)
PSMC1 [cytosol]
(Sus scrofa)
psmc1a [cytosol]
(Danio rerio)
Rpt2 [cytosol]
(Drosophila melanogaster)
rpt-2 [cytosol]
(Caenorhabditis elegans)
RPT2 [cytosol]
(Saccharomyces cerevisiae)
psmC1 [cytosol]
(Dictyostelium discoideum)
mts2 [cytosol]
(Schizosaccharomyces pombe)
psmc1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
XP_016876959.1
,
XP_054232396.1
,
NP_002793.2
,
NP_001317141.1
OpenTargets
ENSG00000100764
ENSEMBL
ENSP00000445147
,
ENST00000261303
,
ENSP00000261303
,
ENSG00000100764
,
ENST00000543772
GeneCards
PSMC1
HPA
ENSG00000100764-PSMC1
PRO
P62191
Pharos - Targets
P62191
GlyGen
P62191
PDB
5T0H
,
7W37
,
5GJR
,
5VGZ
,
9E8L
,
9E8N
,
6MSG
,
6WJN
,
5VFP
,
7W3C
,
7QY7
,
7QXX
,
8K0G
,
7W3F
,
7QYA
,
5VHP
,
9E8G
,
5T0I
,
5VHS
,
8JTI
,
5VHM
,
5VHJ
,
5VHR
,
9E8K
,
5VHQ
,
5T0C
,
9E8I
,
8USC
,
8JRT
,
6MSJ
,
7W3B
,
5VFS
,
7W3A
,
9E8Q
,
7W3I
,
7QXU
,
7W39
,
6MSB
,
7W3G
,
8USD
,
5VFQ
,
6WJD
,
5GJQ
,
5T0G
,
5LN3
,
7QXW
,
9E8O
,
8JRI
,
7QXN
,
7QXP
,
6MSD
,
7W3M
,
7W3K
,
5VHO
,
7QYB
,
5VHH
,
5T0J
,
5VHN
,
5M32
,
5VHI
,
8CVT
,
5L4G
,
9E8H
,
9E8J
,
8USB
,
5VHF
,
7W3J
,
7W3H
,
6MSK
,
5VFT
,
7W38
,
6MSH
,
5VFU
,
5VFR
Interactors (48)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13200 PSMD2
5
PSMD2 [cytosol]
(R-HSA-68796)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
0.961
20
UniProt:Q16401 PSMD5
1
PSMD5 [cytosol]
(R-HSA-68802)
0.944
15
UniProt:P62333 PSMC6
2
PSMC6 [cytosol]
(R-HSA-68783)
PSMC6 [nucleoplasm]
(R-HSA-174319)
0.902
9
UniProt:P35998 PSMC2
5
PSMC2 [cytosol]
(R-HSA-68771)
PSMC2 [nucleoplasm]
(R-HSA-174332)
PSMC2 [secretory granule lumen]
(R-HSA-6800994)
PSMC2 [extracellular region]
(R-HSA-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-HSA-6800421)
0.893
10
UniProt:P62195 PSMC5
2
PSMC5 [cytosol]
(R-HSA-68780)
PSMC5 [nucleoplasm]
(R-HSA-174312)
0.877
15
UniProt:P43686 PSMC4
2
PSMC4 [cytosol]
(R-HSA-68777)
PSMC4 [nucleoplasm]
(R-HSA-174315)
0.857
7
UniProt:O75832 PSMD10
1
PSMD10 [cytosol]
(R-HSA-68788)
0.848
7
UniProt:Q99460 PSMD1
4
PSMD1 [cytosol]
(R-HSA-68786)
PSMD1 [nucleoplasm]
(R-HSA-174348)
PSMD1 [azurophil granule lumen]
(R-HSA-6798741)
PSMD1 [extracellular region]
(R-HSA-6806194)
0.802
5
UniProt:P51665 PSMD7
5
PSMD7 [cytosol]
(R-HSA-68806)
PSMD7 [nucleoplasm]
(R-HSA-174309)
PSMD7 [secretory granule lumen]
(R-HSA-6801008)
PSMD7 [extracellular region]
(R-HSA-6806488)
PSMD7 [ficolin-1-rich granule lumen]
(R-HSA-6800406)
0.788
6
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.788
7
UniProt:Q16186 ADRM1
2
ADRM1 [cytosol]
(R-HSA-5665939)
ADRM1 [nucleoplasm]
(R-HSA-9918361)
0.788
7
UniProt:P17980 PSMC3
5
PSMC3 [cytosol]
(R-HSA-68774)
PSMC3 [nucleoplasm]
(R-HSA-174313)
PSMC3 [secretory granule lumen]
(R-HSA-6800917)
PSMC3 [extracellular region]
(R-HSA-6806496)
PSMC3 [ficolin-1-rich granule lumen]
(R-HSA-6800429)
0.788
7
UniProt:P55036 PSMD4
1
PSMD4 [cytosol]
(R-HSA-68800)
0.744
5
UniProt:Q9UNM6 PSMD13
5
PSMD13 [cytosol]
(R-HSA-68794)
PSMD13 [nucleoplasm]
(R-HSA-174326)
PSMD13 [secretory granule lumen]
(R-HSA-6800983)
PSMD13 [extracellular region]
(R-HSA-6806469)
PSMD13 [ficolin-1-rich granule lumen]
(R-HSA-6800413)
0.744
5
UniProt:Q15008 PSMD6
5
PSMD6 [cytosol]
(R-HSA-68804)
PSMD6 [nucleoplasm]
(R-HSA-174316)
PSMD6 [secretory granule lumen]
(R-HSA-6801036)
PSMD6 [extracellular region]
(R-HSA-6806486)
PSMD6 [ficolin-1-rich granule lumen]
(R-HSA-6800440)
0.744
4
UniProt:Q9BRP4 PAAF1
1
PAAF1 [cytosol]
(R-HSA-9907973)
0.744
4
UniProt:O00232 PSMD12
5
PSMD12 [cytosol]
(R-HSA-68792)
PSMD12 [nucleoplasm]
(R-HSA-174339)
PSMD12 [secretory granule lumen]
(R-HSA-6800934)
PSMD12 [extracellular region]
(R-HSA-6806480)
PSMD12 [ficolin-1-rich granule lumen]
(R-HSA-6800416)
0.725
5
UniProt:P00441 SOD1
5
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [extracellular region]
(R-HSA-350705)
0.666
5
UniProt:P55072 VCP
8
VCP [cytosol]
(R-HSA-1181251)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [extracellular region]
(R-HSA-6806191)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
0.666
5
UniProt:P54578 USP14
1
USP14 [cytosol]
(R-HSA-5689541)
0.643
3
UniProt:O43242 PSMD3
5
PSMD3 [cytosol]
(R-HSA-68798)
PSMD3 [nucleoplasm]
(R-HSA-174328)
PSMD3 [secretory granule lumen]
(R-HSA-6800873)
PSMD3 [extracellular region]
(R-HSA-6806443)
PSMD3 [ficolin-1-rich granule lumen]
(R-HSA-6800408)
0.643
3
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
0.643
5
UniProt:P49720 PSMB3
2
PSMB3 [cytosol]
(R-HSA-68747)
PSMB3 [nucleoplasm]
(R-HSA-174341)
0.643
4
UniProt:Q504T8 MIDN
0.643
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
0.615
16
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.589
2
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.564
2
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:P43356 MAGA2
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q96BR9 ZBT8A
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q3KNR5 Q3KNR5
0.556
3
UniProt:Q9Y2I1 NISCH
1
NISCH [cytosol]
(R-HSA-9691384)
0.527
2
UniProt:Q13618 CUL3
3
CUL3 [cytosol]
(R-HSA-975979)
CUL3 [nucleoplasm]
(R-HSA-5635033)
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
0.527
2
UniProt:Q53HC0 CCD92
0.527
3
UniProt:P03129 VE7
0.527
2
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.527
2
UniProt:P49721 PSMB2
2
PSMB2 [cytosol]
(R-HSA-68744)
PSMB2 [nucleoplasm]
(R-HSA-174335)
0.527
2
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.527
3
UniProt:O00231 PSMD11
5
PSMD11 [cytosol]
(R-HSA-68790)
PSMD11 [nucleoplasm]
(R-HSA-174327)
PSMD11 [secretory granule lumen]
(R-HSA-6800943)
PSMD11 [extracellular region]
(R-HSA-6806441)
PSMD11 [ficolin-1-rich granule lumen]
(R-HSA-6800436)
0.527
2
UniProt:P17706 PTPN2
3
PTPN2 [nucleoplasm]
(R-HSA-9008891)
PTPN2 [cytosol]
(R-HSA-997292)
p-PTPN2 [cytosol]
(R-HSA-9836510)
0.527
2
UniProt:P28065 PSMB9
3
PSMB9 [cytosol]
(R-HSA-68765)
pro-PSMB9 [cytosol]
(R-HSA-9908136)
PSMB9(1-20) [cytosol]
(R-HSA-9908132)
0.527
3
UniProt:Q5JXX7 TMM31
0.527
3
UniProt:Q8WVY7 UBCP1
0.527
2
UniProt:O00487 PSMD14
5
PSMD14 [cytosol]
(R-HSA-68722)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
0.527
3
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.508
2
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.508
2
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