Reactome | PSMC5 [cytosol]

PSMC5 [cytosol]

Stable Identifier

R-HSA-68780

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Probable 26S protease regulatory subunit 8, 26S proteasome AAA-ATPase subunit RPT6

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P62195 PSMC5

Gene Names

PSMC5, SUG1

Chain

initiator methionine:, chain:2-406

Reference Genes

BioGPS Gene:5705 PSMC5

COSMIC (genes):PSMC5 PSMC5

CTD Gene:5705 PSMC5

dbSNP Gene:5705 PSMC5

ENSEMBL:ENSG00000087191 PSMC5

ENSEMBL_homo_sapiens_GENE:ENSG00000087191.14 PSMC5

HGNC:9552 PSMC5

KEGG Gene (Homo sapiens):5705 PSMC5

Monarch:5705 PSMC5

NCBI Gene:5705 PSMC5

OMIM:601681 PSMC5

UCSC:P62195 PSMC5

Reference Transcript

Other Identifiers

11756554_x_at

16837029

209503_PM_s_at

209503_s_at

3730942

3730943

3730944

3730945

3730946

3730947

3730948

3730953

3730955

3730957

3730959

3730960

3730962

3730964

3730965

3730967

3730968

3730970

3730971

3730972

37766_s_at

5705

8009227

A_23_P164035

GE54277

GO:0000166

GO:0000502

GO:0003824

GO:0005102

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0006351

GO:0006355

GO:0006357

GO:0008134

GO:0008540

GO:0012501

GO:0016020

GO:0016787

GO:0016887

GO:0022624

GO:0030163

GO:0031410

GO:0031531

GO:0036402

GO:0043069

GO:0043161

GO:0043226

GO:0045892

GO:0045893

GO:0070062

GO:0072562

GO:0140296

GO:0140297

GO:0140657

GO:1901800

HMNXSV003036198

ILMN_1780189

L38810_at

PH_hs_0004597

TC17000772.hg

g2661070_3p_a_at

Participates

as a component of

26S proteasome [cytosol] (Homo sapiens)

Other forms of this molecule

PSMC5 [nucleoplasm]

Inferred To

PSMC5 [cytosol] (Bos taurus)

PSMC5 [cytosol] (Caenorhabditis elegans)

PSMC5 [cytosol] (Canis familiaris)

PSMC5 [cytosol] (Drosophila melanogaster)

PSMC5 [cytosol] (Mus musculus)

PSMC5 [cytosol] (Plasmodium falciparum)

PSMC5 [cytosol] (Rattus norvegicus)

PSMC5 [cytosol] (Saccharomyces cerevisiae)

PSMC5 [cytosol] (Schizosaccharomyces pombe)

PSMC5 [cytosol] (Sus scrofa)

psmc5 [cytosol] (Danio rerio)

Ghost homologue of PSMC5 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002796.4, NP_001186092.1

OpenTargets

ENSG00000087191

HPA

ENSG00000087191-PSMC5

GeneCards

P62195

Ensembl

ENSG00000087191, ENST00000581882, ENSP00000364970, ENST00000375812, ENST00000310144, ENSP00000463938, ENSP00000310572, ENST00000580864, ENSP00000462495

PRO

P62195

Pharos - Targets

P62195

PDB

7W3K, 7QY7, 7W3A, 5T0J, 5VFQ, 5L4G, 5VHO, 7QYB, 6MSB, 7W3B, 6MSD, 7W3C, 7W3F, 5VHP, 5VFT, 5LN3, 6MSG, 7W3G, 5GJQ, 7W3H, 5T0G, 6MSH, 5VHS, 5GJR, 5VHI, 7W39, 7W37, 7W3I, 6WJD, 7W3J, 7QXW, 5T0I, 5VHM, 6MSJ, 5VHN, 7QYA, 6WJN, 5VFR, 5VGZ, 2KRK, 6MSK, 5VFS, 7W3M, 5VHQ, 3KW6, 8CVT, 5M32, 5VHF, 5T0C, 7QXN, 5VFU, 5VHR, 7QXP, 5VHH, 7W38, 5T0H, 5VHJ, 5VFP

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.939	17
UniProt:Q13371 PDCL	2	p-S18,S19,S20,S25-PDCL [cytosol] (R-HSA-6814228) PDCL [cytosol] (R-HSA-6813727)	0.919	16
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.802	8
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.758	4
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.725	6
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.643	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	9
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:P35398 RORA	3	RORA [nucleoplasm] (R-HSA-400325) monoSUMO1-K240-RORA [nucleoplasm] (R-HSA-4719422) polySUMO2-K240-RORA [nucleoplasm] (R-HSA-4719425)	0.553	2
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.527	2
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:Q6UWZ7 FAM175A	1	p-S406-FAM175A [nucleoplasm] (R-HSA-5682575)	0.527	2
UniProt:P68871 HBB	8	CO-H+-HBB [cytosol] (R-HSA-1237013) HBB [tertiary granule lumen] (R-HSA-6800191) HBB [ficolin-1-rich granule lumen] (R-HSA-6801015) HBB [endocytic vesicle lumen] (R-HSA-2230936) HBB [extracellular region] (R-HSA-2168872) HBB [late endosome lumen] (R-HSA-9631108) HBB [cytosol] (R-HSA-1008196) HBB [lysosomal lumen] (R-HSA-9625193)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	11