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PSMC5 [cytosol]
Stable Identifier
R-HSA-68780
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Probable 26S protease regulatory subunit 8, 26S proteasome AAA-ATPase subunit RPT6
Locations in the PathwayBrowser for interactor UniProt:P35398 RORA
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Proteasome assembly (Homo sapiens)
PSMC4 binds PSMC5 (Homo sapiens)
PSMC5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62195 PSMC5
Gene Names
PSMC5, SUG1
Chain
initiator methionine:, chain:2-406
Reference Genes
BioGPS Gene:5705 PSMC5
COSMIC (genes):PSMC5 PSMC5
CTD Gene:5705 PSMC5
dbSNP Gene:5705 PSMC5
ENSEMBL:ENSG00000087191 PSMC5
HGNC:9552 PSMC5
KEGG:hsa:5705 PSMC5
Monarch:5705 PSMC5
NCBI Gene:5705 PSMC5
OMIM:601681 PSMC5
UCSC:P62195 PSMC5
Reference Transcript
RefSeq:NM_001199163.1 PSMC5
RefSeq:NM_002805.5 PSMC5
Other Identifiers
11756554_x_at
16837029
209503_PM_s_at
209503_s_at
3730942
3730943
3730944
3730945
3730946
3730947
3730948
3730949
3730950
3730951
3730952
3730953
3730954
3730955
3730956
3730957
3730958
3730959
3730960
3730961
3730962
3730963
3730964
3730965
3730966
3730967
3730968
3730969
3730970
3730971
3730972
3730973
37766_s_at
5705
8009227
A_14_P106486
A_14_P125043
A_23_P164035
GE54277
GO:0000502
GO:0003824
GO:0005102
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005838
GO:0006355
GO:0006357
GO:0008134
GO:0008540
GO:0016020
GO:0016787
GO:0016887
GO:0022624
GO:0030163
GO:0031410
GO:0031531
GO:0036402
GO:0043069
GO:0043161
GO:0043226
GO:0045892
GO:0045893
GO:0070062
GO:0072562
GO:0140296
GO:0140297
GO:0140657
GO:1901800
HMNXSV003036198
ILMN_1780189
L38810_at
PH_hs_0004597
TC17000772.hg
g2661070_3p_a_at
Participates
as an input of
PSMC4 binds PSMC5 (Homo sapiens)
as a component of
PSMC4:PSMC5 [cytosol] (Homo sapiens)
Other forms of this molecule
PSMC5 [nucleoplasm]
Inferred To
PSMC5 [cytosol]
(Caenorhabditis elegans)
PSMC5 [cytosol]
(Canis familiaris)
PSMC5 [cytosol]
(Drosophila melanogaster)
PSMC5 [cytosol]
(Gallus gallus)
PSMC5 [cytosol]
(Mus musculus)
PSMC5 [cytosol]
(Plasmodium falciparum)
PSMC5 [cytosol]
(Rattus norvegicus)
PSMC5 [cytosol]
(Saccharomyces cerevisiae)
PSMC5 [cytosol]
(Schizosaccharomyces pombe)
PSMC5 [cytosol]
(Sus scrofa)
psmc5 [cytosol]
(Danio rerio)
psmc5 [cytosol]
(Xenopus tropicalis)
bPSMC5 [cytosol]
(Bos taurus)
Ghost homologue of PSMC5 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001186092.1
,
NP_002796.4
OpenTargets
ENSG00000087191
ENSEMBL
ENSP00000364970
,
ENSP00000462495
,
ENST00000580864
,
ENSP00000310572
,
ENST00000375812
,
ENST00000581882
,
ENSP00000463938
,
ENST00000310144
HPA
ENSG00000087191-PSMC5
PRO
P62195
Pharos - Targets
P62195
GlyGen
P62195
PDB
3KW6
,
5VHH
,
5VHO
,
7QYB
,
5VHI
,
5L4G
,
5GJQ
,
8CVT
,
5T0I
,
7W3F
,
5VHS
,
7QXX
,
7QY7
,
5VHN
,
7W3C
,
5GJR
,
6MSH
,
5T0H
,
5VGZ
,
6WJN
,
6MSG
,
7W37
,
7W38
,
5VHF
,
6MSK
,
7W3H
,
5VFR
,
7W3J
,
5VFU
,
5VFT
,
6WJD
,
2KRK
,
5VHP
,
7QYA
,
5VHQ
,
5T0C
,
5VHR
,
5VHJ
,
5T0J
,
7W3K
,
7W3M
,
7QXN
,
7QXP
,
6MSD
,
5M32
,
5VHM
,
7W39
,
5T0G
,
5LN3
,
7QXW
,
7W3G
,
7QXU
,
7W3B
,
6MSB
,
7W3A
,
7W3I
,
5VFP
,
5VFQ
,
6MSJ
,
5VFS
Interactors (71)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62333 PSMC6
2
PSMC6 [cytosol]
(R-HSA-68783)
PSMC6 [nucleoplasm]
(R-HSA-174319)
0.939
17
UniProt:P43686 PSMC4
2
PSMC4 [nucleoplasm]
(R-HSA-174315)
PSMC4 [cytosol]
(R-HSA-68777)
0.938
20
UniProt:Q13371 PDCL
2
p-S18,S19,S20,S25-PDCL [cytosol]
(R-HSA-6814228)
PDCL [cytosol]
(R-HSA-6813727)
0.919
16
UniProt:P35998 PSMC2
5
PSMC2 [cytosol]
(R-HSA-68771)
PSMC2 [nucleoplasm]
(R-HSA-174332)
PSMC2 [secretory granule lumen]
(R-HSA-6800994)
PSMC2 [extracellular region]
(R-HSA-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-HSA-6800421)
0.864
14
UniProt:P62191 PSMC1
2
PSMC1 [cytosol]
(R-HSA-68768)
PSMC1 [nucleoplasm]
(R-HSA-174338)
0.84
14
UniProt:Q13200 PSMD2
5
PSMD2 [cytosol]
(R-HSA-68796)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
0.823
14
UniProt:O75832 PSMD10
1
PSMD10 [cytosol]
(R-HSA-68788)
0.802
11
UniProt:Q96BD8 SKA1
1
SKA1 [cytosol]
(R-HSA-376228)
0.8
8
UniProt:Q9BRP4 PAAF1
1
PAAF1 [cytosol]
(R-HSA-9907973)
0.793
6
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.788
8
UniProt:P51665 PSMD7
5
PSMD7 [cytosol]
(R-HSA-68806)
PSMD7 [nucleoplasm]
(R-HSA-174309)
PSMD7 [secretory granule lumen]
(R-HSA-6801008)
PSMD7 [extracellular region]
(R-HSA-6806488)
PSMD7 [ficolin-1-rich granule lumen]
(R-HSA-6800406)
0.788
6
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.758
4
UniProt:Q99460 PSMD1
4
PSMD1 [extracellular region]
(R-HSA-6806194)
PSMD1 [azurophil granule lumen]
(R-HSA-6798741)
PSMD1 [nucleoplasm]
(R-HSA-174348)
PSMD1 [cytosol]
(R-HSA-68786)
0.758
12
UniProt:P17980 PSMC3
5
PSMC3 [cytosol]
(R-HSA-68774)
PSMC3 [nucleoplasm]
(R-HSA-174313)
PSMC3 [secretory granule lumen]
(R-HSA-6800917)
PSMC3 [extracellular region]
(R-HSA-6806496)
PSMC3 [ficolin-1-rich granule lumen]
(R-HSA-6800429)
0.758
10
UniProt:P55036 PSMD4
1
PSMD4 [cytosol]
(R-HSA-68800)
0.744
5
UniProt:Q15008 PSMD6
5
PSMD6 [cytosol]
(R-HSA-68804)
PSMD6 [nucleoplasm]
(R-HSA-174316)
PSMD6 [secretory granule lumen]
(R-HSA-6801036)
PSMD6 [extracellular region]
(R-HSA-6806486)
PSMD6 [ficolin-1-rich granule lumen]
(R-HSA-6800440)
0.744
6
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.742
5
UniProt:O00231 PSMD11
5
PSMD11 [cytosol]
(R-HSA-68790)
PSMD11 [nucleoplasm]
(R-HSA-174327)
PSMD11 [secretory granule lumen]
(R-HSA-6800943)
PSMD11 [extracellular region]
(R-HSA-6806441)
PSMD11 [ficolin-1-rich granule lumen]
(R-HSA-6800436)
0.725
5
UniProt:O43242 PSMD3
5
PSMD3 [cytosol]
(R-HSA-68798)
PSMD3 [nucleoplasm]
(R-HSA-174328)
PSMD3 [secretory granule lumen]
(R-HSA-6800873)
PSMD3 [extracellular region]
(R-HSA-6806443)
PSMD3 [ficolin-1-rich granule lumen]
(R-HSA-6800408)
0.725
7
UniProt:Q16186 ADRM1
2
ADRM1 [cytosol]
(R-HSA-5665939)
ADRM1 [nucleoplasm]
(R-HSA-9918361)
0.725
6
UniProt:Q9UNM6 PSMD13
5
PSMD13 [cytosol]
(R-HSA-68794)
PSMD13 [nucleoplasm]
(R-HSA-174326)
PSMD13 [secretory granule lumen]
(R-HSA-6800983)
PSMD13 [extracellular region]
(R-HSA-6806469)
PSMD13 [ficolin-1-rich granule lumen]
(R-HSA-6800413)
0.669
5
UniProt:O76015 KRT38
1
KRT38 [cytosol]
(R-HSA-6809615)
0.666
6
UniProt:Q53GL0 PKHO1
0.664
10
UniProt:P62508-3 ESRRG
0.659
5
UniProt:Q96EK4 THA11
0.659
3
UniProt:O00487 PSMD14
5
PSMD14 [cytosol]
(R-HSA-68722)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
0.643
4
UniProt:Q16401 PSMD5
1
PSMD5 [cytosol]
(R-HSA-68802)
0.643
4
UniProt:P28065 PSMB9
3
pro-PSMB9 [cytosol]
(R-HSA-9908136)
PSMB9 [cytosol]
(R-HSA-68765)
PSMB9(1-20) [cytosol]
(R-HSA-9908132)
0.643
4
UniProt:O00232 PSMD12
5
PSMD12 [cytosol]
(R-HSA-68792)
PSMD12 [nucleoplasm]
(R-HSA-174339)
PSMD12 [secretory granule lumen]
(R-HSA-6800934)
PSMD12 [extracellular region]
(R-HSA-6806480)
PSMD12 [ficolin-1-rich granule lumen]
(R-HSA-6800416)
0.643
4
UniProt:Q15018 FAM175B
1
FAM175B [cytosol]
(R-HSA-5691428)
0.643
4
UniProt:Q15311 RALBP1
1
RALBP1 [cytosol]
(R-HSA-195194)
0.643
4
UniProt:P49720 PSMB3
2
PSMB3 [cytosol]
(R-HSA-68747)
PSMB3 [nucleoplasm]
(R-HSA-174341)
0.643
4
UniProt:P19447 ERCC3
1
ERCC3 [nucleoplasm]
(R-HSA-67439)
0.576
4
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.569
9
UniProt:P51449 RORC
1
RORC [nucleoplasm]
(R-HSA-446177)
0.556
3
UniProt:Q9BYV9 BACH2
0.556
3
UniProt:P06753 TPM3
3
TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710848)
TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710837)
TPM3 [cytosol]
(R-HSA-390543)
0.556
3
UniProt:Q8IYR0 CF206
0.556
3
UniProt:Q7Z3Y8 KRT27
1
KRT27 [cytosol]
(R-HSA-6809587)
0.556
3
UniProt:Q6FG41 Q6FG41
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:Q13515 BFSP2
0.556
3
UniProt:P10826-2 RARB
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
UniProt:P48788 TNNI2
1
TNNI2 [cytosol]
(R-HSA-390538)
0.556
3
UniProt:Q92753-1 Q927531
0.556
3
UniProt:P09493-10 TPM1
0.556
3
IntAct:EBI-16435328 CCSB ORF ID
0.556
3
UniProt:P13805 TNNT1
1
TNNT1 [cytosol]
(R-HSA-390544)
0.553
2
UniProt:P19012 KRT15
1
KRT15 [cytosol]
(R-HSA-6809589)
0.553
2
UniProt:P35398 RORA
3
polySUMO2-K240-RORA [nucleoplasm]
(R-HSA-4719425)
monoSUMO1-K240-RORA [nucleoplasm]
(R-HSA-4719422)
RORA [nucleoplasm]
(R-HSA-400325)
0.553
2
UniProt:Q9NR09 BIRC6
2
BIRC6(1-958)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713451)
BIRC6(1-958)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713450)
0.527
2
UniProt:P46063 RECQ1
0.527
2
UniProt:Q53HC0 CCD92
0.527
2
UniProt:Q9H9E3 COG4
2
COG4 [trans-Golgi network membrane]
(R-HSA-6813868)
COG4 [Golgi membrane]
(R-HSA-6808722)
0.527
2
UniProt:Q8IWB1 IPRI
0.527
2
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.527
2
UniProt:Q8IWJ2 GCC2
3
GCC2 [cytosol]
(R-HSA-6813880)
GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9713455)
GCC2(1-1204)-ALK(1059-1620) fusion [cytosol]
(R-HSA-9713458)
0.527
3
UniProt:P68871 HBB
8
HBB [lysosomal lumen]
(R-HSA-9625193)
HBB [cytosol]
(R-HSA-1008196)
HBB [late endosome lumen]
(R-HSA-9631108)
HBB [tertiary granule lumen]
(R-HSA-6800191)
HBB [extracellular region]
(R-HSA-2168872)
HBB [ficolin-1-rich granule lumen]
(R-HSA-6801015)
HBB [endocytic vesicle lumen]
(R-HSA-2230936)
CO-H+-HBB [cytosol]
(R-HSA-1237013)
0.527
2
UniProt:Q5VSL9 STRP1
0.527
2
UniProt:Q8N1B4 VPS52
1
VPS52 [trans-Golgi network membrane]
(R-HSA-6811029)
0.527
2
UniProt:O14715 RGPD8
0.527
3
UniProt:Q99666 RGPD5
0.527
3
UniProt:O43805 SSNA1
1
SSNA1 [cytosol]
(R-HSA-380255)
0.527
3
UniProt:Q6UWZ7 FAM175A
1
p-S406-FAM175A [nucleoplasm]
(R-HSA-5682575)
0.527
2
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.527
2
UniProt:P49721 PSMB2
2
PSMB2 [cytosol]
(R-HSA-68744)
PSMB2 [nucleoplasm]
(R-HSA-174335)
0.527
2
UniProt:O00233 PSMD9
1
PSMD9 [cytosol]
(R-HSA-68810)
0.527
2
UniProt:P03255-1
0.524
2
UniProt:O15066 KIF3B
3
KIF3B [ciliary tip]
(R-HSA-5625378)
KIF3B [cilium]
(R-HSA-5624878)
KIF3B [cytosol]
(R-HSA-984662)
0.508
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
11
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