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PSMD3 [cytosol]
Stable Identifier
R-HSA-68798
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
26S proteasome non-ATPase regulatory subunit 3, 26S proteasome regulatory subunit S3, Proteasome subunit p58, 26S proteasome regulatory subunit RPN3
Locations in the PathwayBrowser for interactor UniProt:P25963 NFKBIA
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Proteasome assembly (Homo sapiens)
Formation of the complex of PSMD3, PSMD6, and SEM1 (Homo sapiens)
PSMD3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43242 PSMD3
Gene Names
PSMD3
Chain
chain:1-534
Reference Genes
BioGPS Gene:5709 PSMD3
COSMIC (genes):PSMD3 PSMD3
CTD Gene:5709 PSMD3
dbSNP Gene:5709 PSMD3
ENSEMBL:ENSG00000108344 PSMD3
ENSEMBL_homo_sapiens_GENE:ENSG00000108344.15 PSMD3
HGNC:9560 PSMD3
KEGG Gene (Homo sapiens):5709 PSMD3
Monarch:5709 PSMD3
NCBI Gene:5709 PSMD3
OMIM:617676 PSMD3
UCSC:O43242 PSMD3
Reference Transcript
RefSeq:NM_002809.3 PSMD3
Other Identifiers
11715515_a_at
11715516_x_at
11749048_a_at
16833934
201388_PM_at
201388_at
3720637
3720638
3720639
3720640
3720646
3720647
3720649
3720650
3720651
3720653
3720659
3720660
3720662
3720663
3720665
3720670
3720672
3720673
3720674
39155_at
5709
8006984
A_23_P26783
A_24_P289726
GE81195
GO:0000502
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005829
GO:0005838
GO:0006511
GO:0008541
GO:0016020
GO:0022624
GO:0030163
GO:0030234
GO:0031410
GO:0032991
GO:0034774
GO:0042176
GO:0043161
GO:0043226
GO:0070062
GO:0098772
GO:1904813
HMNXSV003001923
ILMN_1796430
PH_hs_0001007
TC17000485.hg
g4506228_3p_s_at
Participates
as an input of
Formation of the complex of PSMD3, PSMD6, and SEM1 (Homo sapiens)
as a component of
19S RP lid particle 3 [cytosol] (Homo sapiens)
Other forms of this molecule
PSMD3 [secretory granule lumen]
PSMD3 [extracellular region]
PSMD3 [ficolin-1-rich granule lumen]
PSMD3 [nucleoplasm]
Inferred To
Rpn3 [cytosol]
(Drosophila melanogaster)
RPN3 [cytosol]
(Saccharomyces cerevisiae)
bPSMD3 [cytosol]
(Bos taurus)
psmD3 [cytosol]
(Dictyostelium discoideum)
psmd3 [cytosol]
(Danio rerio)
psmd3 [cytosol]
(Xenopus tropicalis)
Ghost homologue of PSMD3 [cytosol]
(Plasmodium falciparum)
rpn3 [cytosol]
(Schizosaccharomyces pombe)
PSMD3 [cytosol]
(Canis familiaris)
PSMD3 [cytosol]
(Gallus gallus)
PSMD3 [cytosol]
(Sus scrofa)
Psmd3 [cytosol]
(Mus musculus)
Psmd3 [cytosol]
(Rattus norvegicus)
rpn-3 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_002800.2
OpenTargets
ENSG00000108344
HPA
ENSG00000108344-PSMD3
GeneCards
O43242
Ensembl
ENSP00000264639
,
ENST00000264639
,
ENSG00000108344
PRO
O43242
Pharos - Targets
O43242
PDB
5VHH
,
7W3H
,
6MSD
,
5VHI
,
7W3G
,
8CVT
,
5T0G
,
6MSK
,
5VFT
,
6MSJ
,
5VFS
,
7W3F
,
7W3M
,
5LN3
,
7W3C
,
5VHF
,
7QY7
,
5M32
,
7QXX
,
5T0C
,
5T0J
,
7QXW
,
6WJD
,
7W3K
,
7QXU
,
6MSE
,
7QYB
,
5T0H
,
7QYA
,
7W3J
,
5VHS
,
5VFP
,
7W3I
,
5T0I
,
7W37
,
6MSB
,
5VFU
,
5GJQ
,
5GJR
,
7W38
,
6WJN
,
5VFR
,
6MSH
,
6MSG
,
5VFQ
,
7W3B
,
7W3A
,
5L4K
,
5VGZ
,
7QXN
,
7W39
,
7QXP
Interactors (38)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.788
6
UniProt:O43298 ZBT43
0.781
7
UniProt:P51665 PSMD7
5
PSMD7 [secretory granule lumen]
(R-HSA-6801008)
PSMD7 [extracellular region]
(R-HSA-6806488)
PSMD7 [ficolin-1-rich granule lumen]
(R-HSA-6800406)
PSMD7 [nucleoplasm]
(R-HSA-174309)
PSMD7 [cytosol]
(R-HSA-68806)
0.725
5
UniProt:P62195 PSMC5
2
PSMC5 [nucleoplasm]
(R-HSA-174312)
PSMC5 [cytosol]
(R-HSA-68780)
0.725
7
UniProt:Q13200 PSMD2
5
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [cytosol]
(R-HSA-68796)
0.669
4
UniProt:P55036 PSMD4
1
PSMD4 [cytosol]
(R-HSA-68800)
0.669
5
UniProt:Q15008 PSMD6
5
PSMD6 [secretory granule lumen]
(R-HSA-6801036)
PSMD6 [extracellular region]
(R-HSA-6806486)
PSMD6 [ficolin-1-rich granule lumen]
(R-HSA-6800440)
PSMD6 [nucleoplasm]
(R-HSA-174316)
PSMD6 [cytosol]
(R-HSA-68804)
0.669
5
UniProt:Q9UNM6 PSMD13
5
PSMD13 [secretory granule lumen]
(R-HSA-6800983)
PSMD13 [extracellular region]
(R-HSA-6806469)
PSMD13 [ficolin-1-rich granule lumen]
(R-HSA-6800413)
PSMD13 [nucleoplasm]
(R-HSA-174326)
PSMD13 [cytosol]
(R-HSA-68794)
0.669
5
UniProt:O75832 PSMD10
1
PSMD10 [cytosol]
(R-HSA-68788)
0.669
5
UniProt:Q9BRP4 PAAF1
1
PAAF1 [cytosol]
(R-HSA-9907973)
0.669
4
UniProt:P60900 PSMA6
2
PSMA6 [nucleoplasm]
(R-HSA-174314)
PSMA6 [cytosol]
(R-HSA-68734)
0.666
4
UniProt:P60896 SEM1
2
SEM1 [nucleoplasm]
(R-HSA-8866665)
SEM1 [cytosol]
(R-HSA-8866674)
0.666
4
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.648
4
UniProt:O00231 PSMD11
5
PSMD11 [secretory granule lumen]
(R-HSA-6800943)
PSMD11 [extracellular region]
(R-HSA-6806441)
PSMD11 [ficolin-1-rich granule lumen]
(R-HSA-6800436)
PSMD11 [nucleoplasm]
(R-HSA-174327)
PSMD11 [cytosol]
(R-HSA-68790)
0.648
4
UniProt:O00232 PSMD12
5
PSMD12 [secretory granule lumen]
(R-HSA-6800934)
PSMD12 [extracellular region]
(R-HSA-6806480)
PSMD12 [ficolin-1-rich granule lumen]
(R-HSA-6800416)
PSMD12 [nucleoplasm]
(R-HSA-174339)
PSMD12 [cytosol]
(R-HSA-68792)
0.643
5
UniProt:P49720 PSMB3
2
PSMB3 [nucleoplasm]
(R-HSA-174341)
PSMB3 [cytosol]
(R-HSA-68747)
0.643
4
UniProt:Q16186 ADRM1
2
ADRM1 [nucleoplasm]
(R-HSA-9918361)
ADRM1 [cytosol]
(R-HSA-5665939)
0.643
4
UniProt:O00487 PSMD14
5
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [cytosol]
(R-HSA-68722)
0.643
3
UniProt:P62191 PSMC1
2
PSMC1 [nucleoplasm]
(R-HSA-174338)
PSMC1 [cytosol]
(R-HSA-68768)
0.643
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.643
6
UniProt:Q16401 PSMD5
1
PSMD5 [cytosol]
(R-HSA-68802)
0.643
4
UniProt:Q9C0F1 CEP44
0.556
3
UniProt:O43395 PRPF3
1
PRPF3 [nucleoplasm]
(R-HSA-6806806)
0.556
3
UniProt:P25963 NFKBIA
9
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P28070 PSMB4
4
PSMB4(1-45) [cytosol]
(R-HSA-9908122)
pro-PSMB4 [cytosol]
(R-HSA-9908138)
PSMB4 [nucleoplasm]
(R-HSA-174343)
PSMB4 [cytosol]
(R-HSA-68750)
0.527
2
UniProt:Q99436 PSMB7
7
PSMB7(1-43) [cytosol]
(R-HSA-9908129)
pro-PSMB7 [cytosol]
(R-HSA-9908145)
PSMB7 [secretory granule lumen]
(R-HSA-6803279)
PSMB7 [extracellular region]
(R-HSA-6806449)
PSMB7 [ficolin-1-rich granule lumen]
(R-HSA-6803312)
PSMB7 [nucleoplasm]
(R-HSA-174331)
PSMB7 [cytosol]
(R-HSA-68759)
0.527
3
UniProt:P54578 USP14
1
USP14 [cytosol]
(R-HSA-5689541)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P43686 PSMC4
2
PSMC4 [nucleoplasm]
(R-HSA-174315)
PSMC4 [cytosol]
(R-HSA-68777)
0.527
4
UniProt:Q53HC0 CCD92
0.527
3
UniProt:Q99460 PSMD1
4
PSMD1 [extracellular region]
(R-HSA-6806194)
PSMD1 [azurophil granule lumen]
(R-HSA-6798741)
PSMD1 [nucleoplasm]
(R-HSA-174348)
PSMD1 [cytosol]
(R-HSA-68786)
0.527
2
UniProt:P25787 PSMA2
5
PSMA2 [secretory granule lumen]
(R-HSA-6803329)
PSMA2 [extracellular region]
(R-HSA-6806506)
PSMA2 [ficolin-1-rich granule lumen]
(R-HSA-6803285)
PSMA2 [nucleoplasm]
(R-HSA-174345)
PSMA2 [cytosol]
(R-HSA-68726)
0.527
3
UniProt:O00233 PSMD9
1
PSMD9 [cytosol]
(R-HSA-68810)
0.527
2
UniProt:P28065 PSMB9
3
PSMB9(1-20) [cytosol]
(R-HSA-9908132)
PSMB9 [cytosol]
(R-HSA-68765)
pro-PSMB9 [cytosol]
(R-HSA-9908136)
0.527
4
UniProt:P17980 PSMC3
5
PSMC3 [secretory granule lumen]
(R-HSA-6800917)
PSMC3 [extracellular region]
(R-HSA-6806496)
PSMC3 [ficolin-1-rich granule lumen]
(R-HSA-6800429)
PSMC3 [nucleoplasm]
(R-HSA-174313)
PSMC3 [cytosol]
(R-HSA-68774)
0.527
3
UniProt:P16885 PLCG2
8
p-PLCG2 [plasma membrane]
(R-HSA-114602)
PLCG2 [plasma membrane]
(R-HSA-114601)
p-Y753,Y759,Y1217-PLCG2 [plasma membrane]
(R-HSA-984816)
PLCG2 [cytosol]
(R-HSA-984806)
p-4Y-PLCG2 [plasma membrane]
(R-HSA-2685601)
p-Y753,Y759-PLCG2 [cytosol]
(R-HSA-5607631)
p-Y753,Y759-PLCG2 [plasma membrane]
(R-HSA-5607640)
p-Y-PLCG2 [cytosol]
(R-HSA-9029105)
0.508
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
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