TNFAIP3 (A20) deubiquitinates RIP2

Stable Identifier
R-HSA-688136
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The deubiquitinase A20 is a negative feedback regulator of inflammatory responses, induced by NFkappaB activation (Krikos et al. 1992) and NOD stimulation (Masumoto et al. 2006). A20 can deubiquitinate RIP2 and restricts NOD2 induced signals (Hitosumatsu et al. 2008).

Literature References
PubMed ID Title Journal Year
18079694 A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

Hasegawa, M, Fujimoto, Y, Lucas, PC, Nakano, H, Fukase, K, Nunez, G, Inohara, N

EMBO J 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Lys63-specific deubiquitinase activity of TNFAIP3 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed