Reactome | PSME3 [cytosol]

PSME3 [cytosol]

Stable Identifier

R-HSA-68816

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasome activator complex subunit 3, Proteasome activator 28-gamma subunit, PA28gamma, PA28g, Activator of multicatalytic protease subunit 3, 11S regulator complex gamma subunit, REG-gamma, Ki nuclear autoantigen

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P61289 PSME3

Gene Names

PSME3

Chain

initiator methionine:, chain:2-254

Reference Genes

BioGPS Gene:10197 PSME3

COSMIC (genes):PSME3 PSME3

CTD Gene:10197 PSME3

dbSNP Gene:10197 PSME3

ENSEMBL:ENSG00000131467 PSME3

HGNC:9570 PSME3

KEGG:hsa:10197 PSME3

Monarch:10197 PSME3

NCBI Gene:10197 PSME3

OMIM:605129 PSME3

UCSC:P61289 PSME3

Reference Transcript

Other Identifiers

10197

11729131_a_at

11729132_a_at

11756207_s_at

16834486

200987_PM_x_at

200987_x_at

200988_PM_s_at

200988_s_at

209852_PM_x_at

209852_x_at

209853_PM_s_at

209853_s_at

3722149

3722151

3722153

3722154

3722155

3722156

3722157

3722158

3722159

3722160

3722161

3722162

3722163

3722164

3722165

3722166

3722167

3722168

3722169

3722170

3722171

3722172

3722173

3722174

3722175

3722176

3722177

3722178

3722179

3722180

3722181

3722183

3722184

3722185

3722186

3722187

39796_at

8007397

A_14_P118735

A_23_P164141

A_24_P344307

A_24_P352864

GE61895

GO:0000502

GO:0002039

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006915

GO:0008537

GO:0012501

GO:0016020

GO:0042802

GO:0043226

GO:0061133

GO:0061136

GO:0097371

GO:0098772

GO:2000045

GO:2001237

HMNXSV003037526

Hs.152978.0.A1_3p_a_at

ILMN_1800975

ILMN_2346573

PH_hs_0009198

TC17000538.hg

U11292_at

g12655138_3p_a_at

g12803696_3p_a_at

g5031996_3p_a_at

Participates

as a component of

PA28gamma homoheptamer [cytosol] (Homo sapiens)

as an input of

Formation of the PA28gamma homoheptamer (Homo sapiens)

Inferred To

psme-3 [cytosol] (Caenorhabditis elegans)

psmE3 [cytosol] (Dictyostelium discoideum)

psme3 [cytosol] (Danio rerio)

psme3 [cytosol] (Xenopus tropicalis)

PSME3 [cytosol] (Gallus gallus)

PSME3 [cytosol] (Plasmodium falciparum)

PSME3 [cytosol] (Sus scrofa)

REG [cytosol] (Drosophila melanogaster)

Psme3 [cytosol] (Mus musculus)

Cross References

OpenTargets

ENSG00000131467

ENSEMBL

ENSG00000131467, ENST00000293362, ENSP00000293362, ENST00000590720, ENST00000441946, ENSP00000409487, ENSP00000466794

GeneCards

PSME3

HPA

ENSG00000131467-PSME3

PRO

P61289

Pharos - Targets

P61289

GlyGen

P61289

PDB

7YQD, 7YQC

Interactors (75)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.86	8
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.841	9
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.841	9
UniProt:P38432 COIL			0.818	10
UniProt:Q9BXC9 BBS2	1	BBS2 [cytosol] (R-HSA-5617637)	0.781	7
UniProt:Q8TBK6 ZCH10			0.781	7
UniProt:P49761 CLK3			0.725	5
UniProt:Q8WVP5 TNFAIP8L1	1	TNFAIP8L1 [cytosol] (R-HSA-8874482)	0.718	6
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.718	6
UniProt:Q9NZ81 PRR13			0.718	6
UniProt:Q96HA8 NTAQ1			0.696	5
UniProt:Q86X02 CDR2L			0.666	6
UniProt:Q6PCT2 FBXL19	1	FBXL19 [cytosol] (R-HSA-8862607)	0.643	5
UniProt:Q96CJ1 EAF2	1	EAF2 [nucleoplasm] (R-HSA-8932790)	0.621	3
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.612	8
UniProt:Q03020	1	ISU1 [mitochondrial matrix] (R-SCE-1362391)	0.61	4
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.602	5
UniProt:O93077 O93077			0.602	11
UniProt:Q9HCE7 SMURF1	2	SMURF1 [cytosol] (R-HSA-975972) SMURF1 [nucleoplasm] (R-HSA-3004548)	0.593	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.576	7
UniProt:Q8WVZ9 KBTBD7	1	KBTBD7 [cytosol] (R-HSA-5658415)	0.556	3
UniProt:Q9NU39 FX4L1			0.556	3
UniProt:Q9NQL9 DMRT3			0.556	3
UniProt:Q6PCT2-2 FBXL19			0.556	3
UniProt:A0A0S2Z645 A0A0S2Z645			0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:Q9UNE2 RPH3L			0.556	3
UniProt:P02489 CRYAA			0.556	3
UniProt:Q64LD2-2 WDR25			0.556	3
UniProt:P53278 YG3A			0.556	3
UniProt:Q32MN6 Q32MN6			0.556	3
UniProt:Q9NWQ4-1 GPATCH2L			0.556	3
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.556	3
IntAct:EBI-16429620 CCSB ORF ID			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:Q9P2Z0 THA10			0.556	3
UniProt:Q15735 INPP5J	1	INPP5J [cytosol] (R-HSA-1604590)	0.556	3
UniProt:Q14689-6 DIP2A			0.556	3
UniProt:P42677 RPS27	2	RPS27 [cytosol] (R-HSA-72361) RPS27 [nucleoplasm] (R-HSA-6791190)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:P31942-2 HNRNPH3			0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:P46682	2	APL6 [Golgi membrane] (R-SCE-434335) APL6 [cytoplasmic vesicle membrane] (R-SCE-434197)	0.556	3
UniProt:P30305 CDC25B	4	CDC25B [nucleoplasm] (R-HSA-69734) CDC25B [cytosol] (R-HSA-157412) p-S-CDC25B [nucleoplasm] (R-HSA-9929936) p-S50,T69,S160,S321,S470-CDC25B [cytosol] (R-HSA-8863644)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9UQ90 SPG7	1	SPG7 [mitochondrial inner membrane] (R-HSA-8953712)	0.556	3
UniProt:P51116 FXR2			0.553	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.544	3
UniProt:Q9GZU8 PIP30			0.527	4
UniProt:Q9H0U9 TSYL1			0.527	3
UniProt:Q9BV97 ZNF747	1	ZNF747 [nucleoplasm] (R-HSA-2586596)	0.527	2
UniProt:O43464 HTRA2	1	HTRA2 [mitochondrial intermembrane space] (R-HSA-56655)	0.527	2
UniProt:P82930 MRPS34	1	MRPS34 [mitochondrial inner membrane] (R-HSA-5368186)	0.527	3
UniProt:Q8N831 TSYL6			0.527	2
UniProt:Q14781 CBX2	1	CBX2 [nucleoplasm] (R-HSA-389110)	0.527	3
UniProt:Q9BUV0 RSRP1			0.527	2
UniProt:P49760 CLK2			0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9BT73 PSMG3	1	PSMG3 [cytosol] (R-HSA-9908033)	0.527	2
UniProt:Q05513 PRKCZ	5	PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.527	3
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.527	2
UniProt:P28065 PSMB9	3	PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	4
UniProt:O14818 PSMA7	2	PSMA7 [cytosol] (R-HSA-68736) PSMA7 [nucleoplasm] (R-HSA-174351)	0.527	2
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [secretory granule lumen] (R-HSA-6803316)	0.527	4
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.527	3
UniProt:Q8WY54 PPM1E	1	PPM1E [nucleoplasm] (R-HSA-9619432)	0.527	2
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [secretory granule lumen] (R-HSA-6803279)	0.527	2
UniProt:P12504 VIF			0.499	2
UniProt:Q86YD7 F90A1			0.488	2
UniProt:P62256 UBE2H	2	Ub-C87-UBE2H [cytosol] (R-HSA-8864203) UBE2H [cytosol] (R-HSA-947638)	0.488	2
UniProt:P54259 ATN1	1	ATN1 [nucleoplasm] (R-HSA-6807083)	0.488	3

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