Ubiquitinated geminin is degraded by the proteasome

Stable Identifier
R-HSA-68825
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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At the beginning of this reaction, 1 molecule of 'geminin:ubiquitin complex' is present. At the end of this reaction, 1 molecule of 'ubiquitin' is present.

This reaction takes place in the 'cytosol' and is mediated by the 'endopeptidase activity' of '26S proteasome'.

Literature References
PubMed ID Title Journal Year
11125146 Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.

Wohlschlegel, JA, Dwyer, BT, Dhar, SK, Cvetic, C, Walter, JC, Dutta, A

Science 2000
9635433 Geminin, an inhibitor of DNA replication, is degraded during mitosis.

McGarry, TJ, Kirschner, MW

Cell 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Created