Reactome | CCNA1 [nucleoplasm]

CCNA1 [nucleoplasm]

Stable Identifier

R-HSA-68891

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cyclin A1

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Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - Processing of DNA double-strand break ends (Homo sapiens)
        
        CDK2 phosphorylates RBBP8 (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA1 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA1 [nucleoplasm] (Homo sapiens)
        
        MRN complex binds CDK2 and RBBP8 (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA1 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA1 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        CDK2 phosphorylates TP53 (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA1 [nucleoplasm] (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Homo sapiens)
        
        CCNA:p-CDK1/2 [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA1 [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T161-CDK1 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA1 [nucleoplasm] (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
        
        Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
        
        CCNA:CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA1 [nucleoplasm] (Homo sapiens)
        
        Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
        
        CCNA:CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P78396 CCNA1

Gene Names

CCNA1

Chain

chain:1-465

Reference Genes

BioGPS Gene:8900 CCNA1

COSMIC (genes):CCNA1 CCNA1

CTD Gene:8900 CCNA1

dbSNP Gene:8900 CCNA1

ENSEMBL:ENSG00000133101 CCNA1

HGNC:1577 CCNA1

KEGG Gene (Homo sapiens):8900 CCNA1

Monarch:8900 CCNA1

NCBI Gene:8900 CCNA1

OMIM:604036 CCNA1

UCSC:P78396 CCNA1

Reference Transcript

Other Identifiers

0001450673

11732350_a_at

16774053

1914_at

205899_at

3485675

3485677

3485678

3485679

3485680

3485681

3485682

3485683

3485684

3485686

3485687

3485688

3485689

3485691

3485692

7968637

8900

A_14_P104510

A_23_P48414

GE80093

GO:0000003

GO:0000079

GO:0000083

GO:0000278

GO:0000307

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0006464

GO:0007049

GO:0007141

GO:0007283

GO:0008150

GO:0009058

GO:0015630

GO:0016538

GO:0016579

GO:0030234

GO:0032991

GO:0034641

GO:0042025

GO:0043226

GO:0044772

GO:0051301

GO:0097123

GO:0097124

HMNXSV003022709

ILMN_1726415

ILMN_2157099

PH_hs_0019647

TC13000124.hg

U66838_at

g4502610_3p_at

Participates

as a member of

CCNA1,CCNA2 [nucleoplasm] (Homo sapiens)

as a component of

CCNA1:p-T161-CDK1 [nucleoplasm] (Homo sapiens)

as an output of

CCNA1 gene expression is stimulated by E2F1 (Homo sapiens)

as a candidate of

CCNA [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PolyUb-CCNA1 [nucleoplasm]

CCNA1 [cytosol]

Inferred To

ccng2 [nucleoplasm] (Xenopus tropicalis)

rem1 [nucleoplasm] (Schizosaccharomyces pombe)

CLB6 [nucleoplasm] (Saccharomyces cerevisiae)

CLB1 [nucleoplasm] (Saccharomyces cerevisiae)

Ccna1 [nucleoplasm] (Mus musculus)

Ccna1 [nucleoplasm] (Rattus norvegicus)

CLB2 [nucleoplasm] (Saccharomyces cerevisiae)

CycA [nucleoplasm] (Drosophila melanogaster)

cycB [nucleoplasm] (Dictyostelium discoideum)

CLB3 [nucleoplasm] (Saccharomyces cerevisiae)

cyd-1 [nucleoplasm] (Caenorhabditis elegans)

cya-1 [nucleoplasm] (Caenorhabditis elegans)

CLB4 [nucleoplasm] (Saccharomyces cerevisiae)

CycJ [nucleoplasm] (Drosophila melanogaster)

cig2 [nucleoplasm] (Schizosaccharomyces pombe)

CCNA1 [nucleoplasm] (Caenorhabditis elegans)

CCNA1 [nucleoplasm] (Canis familiaris)

CCNA1 [nucleoplasm] (Dictyostelium discoideum)

CCNA1 [nucleoplasm] (Gallus gallus)

CCNA1 [nucleoplasm] (Plasmodium falciparum)

CCNA1 [nucleoplasm] (Sus scrofa)

ccna1 [nucleoplasm] (Danio rerio)

CLB5 [nucleoplasm] (Saccharomyces cerevisiae)

puc1 [nucleoplasm] (Schizosaccharomyces pombe)

cig1 [nucleoplasm] (Schizosaccharomyces pombe)

CLN1 [nucleoplasm] (Saccharomyces cerevisiae)

CLN2 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of CCNA1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of CCNA1 [nucleoplasm] (Dictyostelium discoideum)

Homologues of CCNA1 [nucleoplasm] (Drosophila melanogaster)

Homologues of CCNA1 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of CCNA1 [nucleoplasm] (Schizosaccharomyces pombe)

cdc13 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_011533596.1, XP_011533598.1, XP_011533597.1, NP_001104516.1, NP_001104517.1, NP_001104515.1, NP_003905.1

OpenTargets

ENSG00000133101

GeneCards

P78396

HPA

ENSG00000133101-CCNA1

Ensembl

ENSP00000486017, ENSG00000133101, ENSP00000255465, ENST00000630422, ENSP00000400666, ENST00000440264, ENST00000625767, ENST00000255465, ENSP00000486482

PRO

P78396

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38936 CDKN1A	5	p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614) CDKN1A [cytosol] (R-HSA-182512) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585)	0.838	8
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.72	6
UniProt:Q05397 PTK2	11	p-5Y-PTK2 [cytosol] (R-HSA-5218711) pY-PTK2 [cytosol] (R-HSA-9632393) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.536	2

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