Orc1 is phosphorylated by cyclin A/CDK2

Stable Identifier
R-HSA-68944
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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Orc1 is phosphorylated by cyclin A/CDK2
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'pre-replicative complex' are present. At the end of this reaction, 1 molecule of 'phosphorylated Orc1', 1 molecule of 'pre-replicative complex (Orc1-minus)', and 1 molecule of 'ADP' are present.

This reaction takes place in the 'nucleus' and is mediated by the 'kinase activity' of 'Cyclin A:Cdk2 complex'.

Literature References
PubMed ID Title Journal Year
11931757 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.

Mendez, J, Zou-Yang, XH, Kim, SY, Hidaka, M, Tansey, WP, Stillman, B

Mol Cell 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNA:p-T160-CDK2 [nucleoplasm]
Physical Entity
CCNA:p-T160-CDK2 [nucleoplasm]
Activity
cyclin-dependent protein serine/threonine kinase activity (0004693)
Orthologous Events
Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)
Orc1 is phosphorylated by cyclin A/CDK2 (Danio rerio)
Orc1 is phosphorylated by cyclin A/CDK2 (Gallus gallus)
Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)
Orc1 is phosphorylated by cyclin A/CDK2 (Rattus norvegicus)
Orc1 is phosphorylated by cyclin A/CDK2 (Saccharomyces cerevisiae)
Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
Orc1 is phosphorylated by cyclin A/CDK2 (Xenopus tropicalis)