The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin

Stable Identifier
R-HSA-68950
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'dTTP', 1 molecule of 'dGTP', 1 molecule of 'dATP', 1 molecule of 'RNA primer:origin duplex:DNA polymerase alpha:primase complex', and 1 molecule of 'dCTP' are present. At the end of this reaction, 1 molecule of 'RNA primer-DNA primer:origin duplex' is present.

This reaction takes place in the 'nucleus' and is mediated by the 'DNA-directed DNA polymerase activity' of 'DNA polymerase alpha:primase'.

Literature References
PubMed ID Title Journal Year
6094569 Purification of a DNA polymerase-DNA primase complex from calf thymus glands

Chang, LM, Rafter, E, Augl, C, Bollum, FJ

J. Biol. Chem. 1984
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA-directed DNA polymerase activity of DNA polymerase alpha:primase [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Cite Us!