DNA replication initiation

Stable Identifier
R-HSA-68952
Type
Pathway
Species
Homo sapiens
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DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA (Frick & Richardson 2002; Wang et al 1984).

Literature References
PubMed ID Title Journal Year
6693436 DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.

Wang, TS, Hu, SZ, Korn, D

J Biol Chem 1984
11395402 DNA primases.

Frick, DN, Richardson, CC

Annu Rev Biochem 2002
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