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CDK-mediated phosphorylation and removal of Cdc6
Stable Identifier
R-HSA-69017
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
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As cells enter S phase, HsCdc6p is phosphorylated by CDK promoting its export from the nucleus (see Bell and Dutta 2002).
Literature References
PubMed ID
Title
Journal
Year
12045100
DNA replication in eukaryotic cells.
Bell, SP
,
Dutta, A
Annu Rev Biochem
2002
11046155
Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis.
Mendez, J
,
Stillman, B
Mol Cell Biol
2000
Participants
Events
Cdc6 protein is phosphorylated by CDK
(Homo sapiens)
Phosphorylated Cdc6 is exported from the nucleus
(Homo sapiens)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
(Homo sapiens)
Ubiquitinated Cdc6 is degraded by the proteasome
(Homo sapiens)
Participates
as an event of
Switching of origins to a post-replicative state (Homo sapiens)
Orthologous Events
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Caenorhabditis elegans)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Danio rerio)
CDK-mediated phosphorylation and removal of Cdc6 (Dictyostelium discoideum)
CDK-mediated phosphorylation and removal of Cdc6 (Drosophila melanogaster)
CDK-mediated phosphorylation and removal of Cdc6 (Gallus gallus)
CDK-mediated phosphorylation and removal of Cdc6 (Mus musculus)
CDK-mediated phosphorylation and removal of Cdc6 (Plasmodium falciparum)
CDK-mediated phosphorylation and removal of Cdc6 (Rattus norvegicus)
CDK-mediated phosphorylation and removal of Cdc6 (Saccharomyces cerevisiae)
CDK-mediated phosphorylation and removal of Cdc6 (Schizosaccharomyces pombe)
CDK-mediated phosphorylation and removal of Cdc6 (Sus scrofa)
CDK-mediated phosphorylation and removal of Cdc6 (Xenopus tropicalis)
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