RFC binding displaces Pol Alpha

Stable Identifier
R-HSA-69053
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Once the RNA-DNA primer is synthesized, replication factor C (RFC) initiates a reaction called "polymerase switching"; pol delta, the processive enzyme replaces pol alpha, the priming enzyme. RFC binds to the 3'-end of the RNA-DNA primer on the Primosome, to displace the pol alpha primase complex. The binding of RFC triggers the binding of the primer recognition complex.

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Orthologous Events