Loading of PCNA - Sliding Clamp Formation

Stable Identifier
R-HSA-69063
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The binding of the primer recognition complex involves the loading of proliferating cell nuclear antigen (PCNA). Replication Factor C transiently opens the PCNA toroid in an ATP-dependent reaction, and then allows PCNA to re-close around the double helix adjacent to the primer terminus. This leads to the formation of the "sliding clamp".

Literature References
Participants
Participant Of
Orthologous Events