Joining of adjacent Okazaki fragments

Stable Identifier
R-HSA-69173
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Removal of the flap by FEN-1 leads to the generation of a nick between the 3'-end of the upstream Okazaki fragment and the 5'-end of the downstream Okazaki fragment. DNA ligase I then seals the nicks between adjacent processed Okazaki fragments to generate intact double-stranded DNA.
Literature References
PubMed ID Title Journal Year
9081985 Enzymes and reactions at the eukaryotic DNA replication fork.

Bambara, RA, Murante, RS, Henricksen, LA

J Biol Chem 1997
Participants
Participates
Catalyst Activity

DNA ligase activity of LIG1 [nucleoplasm]

Orthologous Events
Cite Us!