Reactome | p-T172-CDK4,p-T177-CDK6 [nucleoplasm]

p-T172-CDK4,p-T177-CDK6 [nucleoplasm]

Stable Identifier

R-HSA-69211

Type

Set [CandidateSet]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
      - Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
        
        Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)

Participants

members

p-T172-CDK4 [nucleoplasm] (Homo sapiens)

candidates

p-T177-CDK6 [nucleoplasm] (Homo sapiens)

Participates

as a component of

p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)

Inferred To

p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Bos taurus)

p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Canis familiaris)

p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Drosophila melanogaster)

p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Mus musculus)

p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)

p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Sus scrofa)

p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Xenopus tropicalis)

phospho-p-T172-CDK4 [nucleoplasm] (Danio rerio)

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