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CDK7 [nucleoplasm]
Stable Identifier
R-HSA-69218
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cdk7, Cell division protein kinase 7 (EC 2.7.1.-) (CDK-activating kinase) (CAK)(TFIIH) (basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15)(STK1)(CAK1), Cell division protein kinase 7 , CDK-activating kinase, CAK, TFIIH basal transcription factor complex kinase subunit, 39 kDa protein kinase, P39 Mo15, STK1, CAK1
Locations in the PathwayBrowser for interactor UniProt:P08238
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)
CDK7 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50613 CDK7
Gene Names
CDK7, CAK, CAK1, CDKN7, MO15, STK1
Chain
initiator methionine:, chain:2-346
Reference Genes
BioGPS Gene:1022 CDK7
COSMIC (genes):CDK7 CDK7
CTD Gene:1022 CDK7
dbSNP Gene:1022 CDK7
ENSEMBL:ENSG00000134058 CDK7
ENSEMBL_homo_sapiens_GENE:ENSG00000134058.12 CDK7
ENSEMBL_homo_sapiens_GENE:ENSG00000277273.5 CDK7
HGNC:1778 CDK7
KEGG Gene (Homo sapiens):1022 CDK7
Monarch:1022 CDK7
NCBI Gene:1022 CDK7
OMIM:601955 CDK7
UCSC:P50613 CDK7
Reference Transcript
RefSeq:NM_001324070.1 CDK7
RefSeq:NM_001324077.1 CDK7
RefSeq:NM_001324069.1 CDK7
RefSeq:NM_001324071.1 CDK7
RefSeq:NM_001799.3 CDK7
Other Identifiers
1022
11717845_a_at
16985637
1969_s_at
211297_PM_s_at
211297_s_at
2813483
2813484
2813486
2813490
2813492
2813493
2813498
2813499
2813500
2813503
2813505
2813506
2813507
2813508
33317_at
8105862
8177462
A_23_P133585
GE79229
GO:0000079
GO:0000166
GO:0000278
GO:0000439
GO:0001650
GO:0001673
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005675
GO:0005730
GO:0005737
GO:0005829
GO:0005886
GO:0006281
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006367
GO:0006468
GO:0006974
GO:0007049
GO:0008094
GO:0008353
GO:0016073
GO:0016301
GO:0016310
GO:0016740
GO:0019907
GO:0036211
GO:0042795
GO:0043226
GO:0045944
GO:0048471
GO:0050821
GO:0051301
GO:0051726
GO:0070516
GO:0070985
GO:0106310
GO:0140096
GO:0140097
GO:0140657
GO:2000045
HMNXSV003054204
ILMN_1778917
L20320_at
PH_hs_0027953
TC05000301.hg
g348242_3p_a_at
Participates
as an input of
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)
as a component of
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
CAK [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of CDK7 [nucleoplasm]
(Plasmodium falciparum)
CDK7 [nucleoplasm]
(Bos taurus)
CDK7 [nucleoplasm]
(Caenorhabditis elegans)
CDK7 [nucleoplasm]
(Canis familiaris)
CDK7 [nucleoplasm]
(Danio rerio)
CDK7 [nucleoplasm]
(Dictyostelium discoideum)
CDK7 [nucleoplasm]
(Drosophila melanogaster)
CDK7 [nucleoplasm]
(Gallus gallus)
CDK7 [nucleoplasm]
(Mus musculus)
CDK7 [nucleoplasm]
(Rattus norvegicus)
CDK7 [nucleoplasm]
(Saccharomyces cerevisiae)
CDK7 [nucleoplasm]
(Schizosaccharomyces pombe)
CDK7 [nucleoplasm]
(Sus scrofa)
CDK7 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001310999.1
,
NP_001311006.1
,
NP_001790.1
,
NP_001311000.1
,
NP_001310998.1
ZINC - World Drugs
CDK7_HUMAN
Guide to Pharmacology - Targets
1979
OpenTargets
ENSG00000134058
ZINC - FDA approved
CDK7_HUMAN
ZINC - Substances
CDK7_HUMAN
ZINC target
P50613
ZINC - Biogenic
CDK7_HUMAN
PRO
P50613
PDB
6XBZ
,
7B5Q
,
8ORM
,
8BYQ
,
7EGB
,
6O9L
,
7ENA
,
1UA2
,
8BVW
,
8P4Z
,
7NVR
,
8GXQ
,
7EGC
,
7ENC
,
8GXS
,
8P6V
,
7B5O
,
7LBM
,
8P6Y
,
6XD3
ZINC - Investigational
CDK7_HUMAN
IntEnz
2.7.11.23
HPA
ENSG00000134058-CDK7
GeneCards
P50613
Ensembl
ENST00000256443
,
ENSG00000277273
,
ENSP00000256443
,
ENST00000615305
,
ENSG00000134058
,
ENSP00000479116
Pharos - Targets
P50613
ZINC - Predictions - Purchasable
CDK7_HUMAN
HMDB Protein
HMDBP01388
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51946 CCNH
1
CCNH [nucleoplasm]
(R-HSA-69220)
0.932
15
UniProt:P51948 MNAT1
1
MNAT1 [nucleoplasm]
(R-HSA-59012)
0.823
11
UniProt:P32780 GTF2H1
1
GTF2H1 [nucleoplasm]
(R-HSA-65912)
0.763
7
UniProt:P19447 ERCC3
1
ERCC3 [nucleoplasm]
(R-HSA-67439)
0.745
7
UniProt:P18074 ERCC2
2
ERCC2 [cytosol]
(R-HSA-2564770)
ERCC2 [nucleoplasm]
(R-HSA-67443)
0.745
7
UniProt:Q6ZYL4 GTF2H5
1
GTF2H5 [nucleoplasm]
(R-HSA-5688446)
0.745
7
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.713
3
UniProt:Q13888 GTF2H2
1
GTF2H2 [nucleoplasm]
(R-HSA-65914)
0.671
9
UniProt:Q13889 GTF2H3
1
GTF2H3 [nucleoplasm]
(R-HSA-65916)
0.671
6
UniProt:P28715 ERCC5
1
ERCC5 [nucleoplasm]
(R-HSA-67447)
0.671
6
UniProt:Q92759 GTF2H4
1
GTF2H4 [nucleoplasm]
(R-HSA-65918)
0.671
6
UniProt:Q96SB4 SRPK1
2
SRPK1 [nucleoplasm]
(R-HSA-9821984)
SRPK1 [cytosol]
(R-HSA-9729349)
0.59
2
UniProt:P78362 SRPK2
1
SRPK2 [cytosol]
(R-HSA-9729332)
0.59
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:Q6P1K8 T2H2L
0.527
2
UniProt:P46013 KI67
0.483
3
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